The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
Open accessAbstract
The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate the accumulation and efficacy of 2-AG at cannabinoid receptors. We found that the recently described serine hydrolase α-β-hydrolase domain 6 (ABHD6) also controls the accumulation and efficacy of 2-AG at cannabinoid receptors. In cells from the BV-2 microglia cell line, ABHD6 knockdown reduced hydrolysis of 2-AG and increased the efficacy with which 2-AG can stimulate CB2-mediated cell migration. ABHD6 was expressed by neurons in primary culture and its inhibition led to activity-dependent accumulation of 2-AG. In adult mouse cortex, ABHD6 was located postsynaptically and its selective inhibition allowed the induction of CB1-dependent long-term depression by otherwise subthreshold stimulation. Our results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system.
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Self-citationBrain monoglyceride lipase participating in endocannabinoid inactivation
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Self-citationSelective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
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The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
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Metadata
- Authors
- Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S.-J., Woodruff, G., Fung, S., Lafourcade, M., Alexander, J. P., Long, J. Z., Li, W., Xu, C., Möller, T., Mackie, K., Manzoni, O. J., Cravatt, B. F., & Stella, N.
- Venue
- Nature Neuroscience
- Published
- 2010-07-25
- Volume
- 13
- Issue
- 8
- Pages
- 951-957
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2159586025
- Cited by
- 441
- References
- 42
- FWCI
- 22.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S.-J., Woodruff, G., Fung, S., Lafourcade, M., Alexander, J. P., Long, J. Z., Li, W., Xu, C., Möller, T., Mackie, K., Manzoni, O. J., . . . Stella, N. (2010). The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nature Neuroscience. https://doi.org/10.1038/nn.2601
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
