The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Animal models of neuropsychiatric disorders
Open accessAbstract
Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment development would benefit greatly from improved animal models. Here we review the current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder. We argue for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders, and for explicit guidelines when animal models are reported.
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“There is a paucity of animal studies of BD mainly because there are no animal models that satisfy the validity criteria for modeling this complex multifactorial disorder130–133.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [132]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These include chronic unpredictable stress, restraint stress or foot-shock stress, followed by behavioral measures of anhedonia (e.g., sucrose preference) or behavioral despair (e.g., forced swim test and tail suspension test), which are often responsive to acute antidepressant treatment and do not address the multiple validities necessary for an effective animal model of depression4.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [4]
Experimental — accuracy not yet measuredIn the citing paper
“However, for complex psychiatric disorders with largely unknown genetic etiologies, environmental insults, specific pathologies, or biomarkers, the building of animal models with high construct validity has not yet been possible [94].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [94]
In the citing paper
“Mice subjected to chronic social defeat stress (CSDS) develop depression-like symptoms [134,135]”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [134]
In the citing paper
“The stress-induced behavioral phenotypes are reversed by chronic, but not acute antidepressant treatment, and are thus posited to have both face and predictive validity [8].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [8]
In the citing paper
“Stressed animals also tend to spend less time struggling against inescapable stressors such as forced swimming or tail suspension.”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [8]
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821
Age of onset of mental disorders: a review of recent literature
Kessler, R. C., Amminger, G. P., Aguilar-Gaxiola, S., Alonso, J., Lee, S., & ??st??n, T. B. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32816ebc8c · Cited by 3,457
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Self-citationMeaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.186 · Cited by 2,323
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Self-citationA Systematic Review of the Prevalence of Schizophrenia
Saha, S., Chant, D., Welham, J., & McGrath, J. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020141 · Cited by 2,168
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Research works printed but not linked: 1
- Markou, A. Animal models of depression and antidepressant activity. Neurosci. Biobehav. Rev. 29, 501 (2005). · DOI
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Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., Fetcho, R. N., Zebley, B., Oathes, D. J., Etkin, A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4246 · Cited by 2,170
Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269
Insel, T. R. (2010) · Nature · doi:10.1038/nature09552 · Cited by 1,783
Metadata
- Authors
- Nestler, E. J., & Hyman, S. E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Harvard University (US)
- Corresponding author
- Nestler, Eric J
- Venue
- Nature Neuroscience
- Published
- 2010-09-27
- Volume
- 13
- Issue
- 10
- Pages
- 1161-1169
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3750731
- OpenAlex
- W2007816528
- Cited by
- 2,023
- References
- 72
- Citations by year
- 2026: 81 · 2025: 109 · 2024: 101 · 2023: 103 · 2022: 114 · 2021: 144 · 2020: 146 · 2019: 160 · 2018: 135 · 2017: 151 · 2016: 131 · 2015: 168 · 2014: 140 · 2013: 109 · 2012: 109
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH090963, R01MH051399, P50MH066172)
- National Institute on Drug Abuse (R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- animal models of psychiatric disorders, schizophrenia, bipolar disorder, depression, neuropsychiatric disorders, model validation, reporting guidelines, biomarkers, treatment development, pathophysiology
- MeSH terms
- Animals, Mental Disorders, Disease Models, Animal, Humans, Nerve Tissue Proteins, Reproducibility of Results, Neurotransmitter Agents
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