The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury
Open accessAbstract
Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal cord hemisections to adult rhesus monkeys and analyzed behavioral, electrophysiological and anatomical adaptations. We found marked spontaneous plasticity of corticospinal projections, with reconstitution of fully 60% of pre-lesion axon density arising from sprouting of spinal cord midline-crossing axons. This extensive anatomical recovery was associated with improvement in coordinated muscle recruitment, hand function and locomotion. These findings identify what may be the most extensive natural recovery of mammalian axonal projections after nervous system injury observed to date, highlighting an important role for primate models in translational disease research.
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Sample size in factor analysis.
MacCallum, R. C., Widaman, K. F., Zhang, S., & Hong, S. (1999) · Psychological Methods · doi:10.1037/1082-989x.4.1.84 · Cited by 5,497
Relation of sample size to the stability of component patterns.
Guadagnoli, E., & Velicer, W. F. (1988) · Psychological Bulletin · doi:10.1037/0033-2909.103.2.265 · Cited by 2,880
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
Courtine, G., Gerasimenko, Y., van den Brand, R., Yew, A., Musienko, P., Zhong, H., Song, B., Ao, Y., Ichiyama, R. M., Lavrov, I., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2401 · Cited by 706
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Cited by
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Self-citationSpinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Self-citationBeauparlant, J., van den Brand, R., Barraud, Q., Friedli, L., Musienko, P., Dietz, V., & Courtine, G. (2013) · Brain · doi:10.1093/brain/awt204 · Cited by 130
Self-citationModality-Specific Axonal Regeneration: Toward Selective Regenerative Neural Interfaces
Lotfi, P., Garde, K., Chouhan, A. K., Bengali, E., & Romero-Ortega, M. I. (2011) · Frontiers in Neuroengineering · doi:10.3389/fneng.2011.00011 · Cited by 42
Metadata
- Authors
- Rosenzweig, E. S., Courtine, G., Jindrich, D. L., Brock, J. H., Ferguson, A. R., Strand, S. C., Nout, Y. S., Roy, R. R., Miller, D. M., Beattie, M. S., Havton, L. A., Bresnahan, J. C., Edgerton, V. R., & Tuszynski, M. H.
- Venue
- Nature Neuroscience
- Published
- 2010-11-14
- Volume
- 13
- Issue
- 12
- Pages
- 1505-1510
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1980859391
- Cited by
- 405
- References
- 3
- FWCI
- 17.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Rosenzweig, E. S., Courtine, G., Jindrich, D. L., Brock, J. H., Ferguson, A. R., Strand, S. C., Nout, Y. S., Roy, R. R., Miller, D. M., Beattie, M. S., Havton, L. A., Bresnahan, J. C., Edgerton, V. R., & Tuszynski, M. H. (2010). Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nature Neuroscience. https://doi.org/10.1038/nn.2691
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
