The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
Open accessAbstract
Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders. In many cases, pathological itch is insensitive to antihistamine treatment. Recent studies have identified members of the Mas-related G protein–coupled receptor (Mrgpr) family that are activated by mast cell mediators and promote histamine-independent itch. MrgprA3 and MrgprC11 act as receptors for the pruritogens chloroquine and BAM8–22, respectively. However, the signaling pathways and transduction channels activated downstream of these pruritogens are largely unknown. We found that TRPA1 is the downstream target of both MrgprA3 and MrgprC11 in cultured sensory neurons and heterologous cells. TRPA1 is required for Mrgpr-mediated signaling, as sensory neurons from TRPA1-deficient mice exhibited markedly diminished responses to chloroquine and BAM8–22. Similarly, TRPA1-deficient mice displayed little to no scratching in response to these pruritogens. Our findings indicate that TRPA1 is an essential component of the signaling pathways that promote histamine-independent itch.
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Cites
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
Bautista, D. M., Jordt, S.-E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,932
Self-citationMustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Jordt, S.-E., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,899
Self-citationNoxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,827
TRPA1 mediates formalin-induced pain
McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M., Hayward, N. J., Chong, J. A., Julius, D., Moran, M. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705924104 · Cited by 1,263
Self-citationIkoma, A., Steinhoff, M., Ständer, S., Yosipovitch, G., & Schmelz, M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1950 · Cited by 949
Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
Liu, Q., Tang, Z., Surdenikova, L., Kim, S., Patel, K. N., Kim, A., Ru, F., Guan, Y., Weng, H.-J., Geng, Y., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.034 · Cited by 813
Self-citationA gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Sun, Y.-G., & Chen, Z.-F. (2007) · Nature · doi:10.1038/nature06029 · Cited by 788
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
Julius, D., MacDermott, A. B., Axel, R., & Jessell, T. M. (1988) · Science · doi:10.1126/science.3399891 · Cited by 694
Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06176.2003 · Cited by 653
Cellular Basis of Itch Sensation
Sun, Y.-G., Zhao, Z.-Q., Meng, X.-L., Yin, J., Liu, X.-Y., & Chen, Z.-F. (2009) · Science · doi:10.1126/science.1174868 · Cited by 609
Cited by
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D. M., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 987
Self-citationCevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 804
Braz, J., Solorzano, C., Wang, X., & Basbaum, A. I. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.018 · Cited by 447
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Metadata
- Authors
- Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M.
- Venue
- Nature Neuroscience
- Published
- 2011-04-03
- Volume
- 14
- Issue
- 5
- Pages
- 595-602
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2087004322
- Cited by
- 599
- References
- 44
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011). TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch. Nature Neuroscience. https://doi.org/10.1038/nn.2789
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