The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
Open accessAbstract
We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD patients. Intracutaneous injection of endogenous PAR-2 agonists provoked enhanced and prolonged itch when applied intralesionally. Moreover, itch upon mast cell degranulation was abolished by local antihistamines in controls but prevailed in AD patients. Thus, we identified enhanced PAR-2 signaling as a new link between inflammatory and sensory phenomena in AD patients. PAR-2 therefore represents a promising therapeutic target for the treatment of cutaneous neurogenic inflammation and pruritus.
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Cites
Protease-activated receptors in inflammation, neuronal signaling and pain
Vergnolle, N., Wallace, J. L., Bunnett, N. W., & Hollenberg, M. D. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01634-5 · Cited by 369
Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
Kawabata, A., Kawao, N., Kuroda, R., Tanaka, A., Itoh, H., & Nishikawa, H. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00020 · Cited by 94
Cited by
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 804
Self-citationA gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Sun, Y.-G., & Chen, Z.-F. (2007) · Nature · doi:10.1038/nature06029 · Cited by 788
Skin pH: from basic science to basic skin care
Ali, S., & Yosipovitch, G. (2013) · Acta Dermato Venereologica · doi:10.2340/00015555-1531 · Cited by 690
Cytokines and chemokines orchestrate atopic skin inflammation
Homey, B., Steinhoff, M., Ruzicka, T., & Leung, D. Y. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.047 · Cited by 579
Self-citationMast cell tryptases and chymases in inflammation and host defense.
Caughey, G. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00509.x · Cited by 442
Metadata
- Authors
- Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-07-16
- Volume
- 23
- Issue
- 15
- Pages
- 6176-6180
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2131309533
- Cited by
- 653
- References
- 2
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin. https://app.cochat.ai/papers/10.1523/jneurosci.23-15-06176.2003
- The paper
- Steinhoff, M., Neisius, U., Ikoma, A., Fartasch, M., Heyer, G., Skov, P. S., Luger, T. A., & Schmelz, M. (2003). Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-15-06176.2003
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