The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold
Open accessAbstract
It takes effort and time to tame one's impulses. Although medial prefrontal cortex (mPFC) is broadly implicated in effortful control over behavior, the subthalamic nucleus (STN) is specifically thought to contribute by acting as a brake on cortico-striatal function during decision conflict, buying time until the right decision can be made. Using the drift diffusion model of decision making, we found that trial-to-trial increases in mPFC activity (EEG theta power, 4–8 Hz) were related to an increased threshold for evidence accumulation (decision threshold) as a function of conflict. Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive choice. In addition, intracranial recordings of the STN area revealed increased activity (2.5–5 Hz) during these same high-conflict decisions. Activity in these slow frequency bands may reflect a neural substrate for cortico–basal ganglia communication regulating decision processes.
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The Diffusion Decision Model: Theory and Data for Two-Choice Decision Tasks
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Visual fixations and the computation and comparison of value in simple choice
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Self-citationHold your horses: a dynamic computational role for the subthalamic nucleus in decision making
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Self-citationThe Electrophysiological Dynamics of Interference during the Stroop Task
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Cortico–basal ganglia circuit mechanism for a decision threshold in reaction time tasks
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Wiecki, T. V., Sofer, I., & Frank, M. J. (2013) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2013.00014 · Cited by 1,047
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Shenhav, A., Musslick, S., Lieder, F., Kool, W., Griffiths, T. L., Cohen, J. D., & Botvinick, M. M. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031526 · Cited by 1,077
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Metadata
- Authors
- Cavanagh, J. F., Wiecki, T. V., Cohen, M. X., Figueroa, C. M., Samanta, J., Sherman, S. J., & Frank, M. J.
- Venue
- Nature Neuroscience
- Published
- 2011-09-25
- Volume
- 14
- Issue
- 11
- Pages
- 1462-1467
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2156743548
- Cited by
- 645
- References
- 9
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Cavanagh, J. F., Wiecki, T. V., Cohen, M. X., Figueroa, C. M., Samanta, J., Sherman, S. J., & Frank, M. J. (2011). Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold. Nature Neuroscience. https://doi.org/10.1038/nn.2925
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
