Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

Ronesi, Jennifer A, Collins, Katie A, Hays, Seth A, Tsai, Nien-Pei, Guo, Weirui, Birnbaum, Shari G, Hu, Jia-Hua, Worley, Paul F, Gibson, Jay R, Huber, Kimberly M·2012·Nature Neuroscience
DOI 10.1038/nn.3033

Cited by (251)

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  9. Intracellular Signaling Networks in Fragile X Syndrome: Approaches to Drug Discovery and Therapeutics
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  10. Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice
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  11. FMRP activates the translation of large autism/intellectual disability proteins and stimulates N-end rule E3 ligase Poe/UBR4 production within puromycin-sensitive RNP particles
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  12. Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility
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  14. Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder
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  15. Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
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  16. Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice
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  17. Evidence for Phosphorylation-Dependent, Dynamic, Regulation of mGlu5 and Homer2 in Expression of Cocaine Aversion in Mice
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  18. [Research advances in the role of mTOR signaling pathway in autism spectrum disorder].
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  19. Structural and Functional Organization of the Postsynaptic Density☆
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  20. Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse model
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  21. University Medical School of Naples "Federico II" Department of Neuroscience, Reproductive and Odontostomatologic Sciences
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  22. The Role of LMO4 in the Regulation of Hippocampal and Amygdalar Synaptic Function
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  23. FMRP and the Pathophysiology of Fragile X Syndrome
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  24. Optogenetic Restoration of Abrogated mGluR Signaling in Fragile X Syndrome
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  25. The Endocannabinoid System in Fragile X Syndrome
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  26. Genetic basis of neurological disorder with human induced pluripotent stem cells
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  27. Role of retinoic acid signaling in homeostatic synaptic plasticity
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  28. Exaggerated Cap-Dependent Translation as a Mechanism for Corticostriatal Dysfunction in Fragile X Syndrome Model Mice
    Claudia Bagni, Eric Klann · 2016
  29. Dysregulated Translation in Autism Spectrum Disorder
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  30. Pet Imaging of mGluR5 in Fragile X Syndrome: A Longitudinal Study Using a FMR1 Knockout Mouse Model
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  31. Faculty Opinions recommendation of Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis.
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  32. Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD
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  33. Faculty Opinions recommendation of Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus.
    E. R. de Kloet, Ioannis Zalachoras · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  34. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
    Maria Meringolo, Martina Montanari, Simona D’Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos et al. · 2024 · Research Square
  35. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
    Maria Meringolo, Martina Montanari, Simona D’Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos et al. · 2025 · Research Square
  36. Identification of neuronal alterations induced by Shank3 mutations using iPS cells from Phelan-McDermid Patients' Fibroblasts
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  37. Additional file 3 of Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
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  38. Additional file 1 of Removal of a partial genomic duplication restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer
    Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang et al. · 2023 · Figshare
  39. Additional file 1 of Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP
    Annie Hien, Gemma Molinaro, Botao Liu, Kimberly M. Huber, Joel D. Richter · 2020 · Figshare
  40. Striatofugal balance and beneficial effects of facilitating nucleus accumbens mGlu4 receptor activity in the Fmr1-/- mouse model of Fragile X Syndrome
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  41. Involvement of mGluR5/Homer crosstalk disruption in the pathophysiology of Fragile X Syndrome
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  42. Behavioral and synaptic consequences following removal of the Il1rapl1 gene in mice, a model of intellectual disability
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  43. Studying Neuronal Connectivity in the Mouse Brain in Normal Condition and Fragile X Syndrome
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  44. Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse model
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  45. Pathophysiological consequences of a Fragile X missense mutation
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  46. Identifying therapeutic targets for the treatment of Fragile X Syndrome : Implications for Autism Spectrum Disorders
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  47. Investigating the physiological function of the amyloid precursor protein in Drosophila melanogaster
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  48. Socio-communicative and nucleus accumbens core dysfunctions in fragile X syndrome
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  49. Pathophysiology of the FMRP-R138Q Fragile X Syndrome missense mutation in mice
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  50. Disruption of the Homer1 coiled-coiled domain by a novel de novo human HOMER1 variant impairs protein scaffolding, calcium signalling, and synaptogenesis
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  51. ATF4 Modulates Group 1 mGluR-Dependent molecular signaling, hippocampal plasticity and behavior
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