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Cited by 97Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationMicrotubule and mitosis dynamics

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis

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Yang, Yu-Ting, Wang, Chia-Lin, Van Aelst, Linda·2012·Nature Neuroscience
DOI 10.1038/nn.3171PMC PMC3431462
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Abstract

Neurogenesis in the developing neocortex relies on the ability of radial glial progenitor cells (RGCs) to switch from proliferative to differentiative neuron-generating divisions, but the molecular mechanisms that control this switch in a correct temporal manner are not well understood. Here, we show that DOCK7, a member of the DOCK180 family of proteins, regulates RGC proliferation versus differentiation. Silencing of DOCK7 in RGCs of developing mouse embryos impedes neuronal differentiation and maintains cells as cycling progenitors. In contrast, DOCK7 overexpression promotes RGC differentiation to basal progenitors and neurons. We further present evidence that DOCK7 influences neurogenesis by controlling apically directed interkinetic nuclear migration of RGCs. DOCK7 exerts its effects by antagonizing the microtubule growth-promoting function of the centrosome-associated protein TACC3. Thus, DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from RGCs during cortical development.

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Cited by

Sorted by citations

Authors
Yang, Y.-T., Wang, C.-L., & Van Aelst, L.
Affiliations
Cold Spring Harbor Laboratory (US)
ORCID
Wang, Chia-Lin
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2012-07-29
Volume
15
Issue
9
Pages
1201-1210
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.3171
PMC
PMC3431462
OpenAlex
W2125568248
Cited by
97
References
3
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 13 · 2014: 15 · 2013: 9 · 2012: 1
FWCI
4.10
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH082808, MH082808)
  • National Cancer Institute (T32CA148056, T32 CA 148056-1)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
DOCK7, TACC3, interkinetic nuclear migration, cortical neurogenesis, centrosome, microtubule growth, neuronal differentiation, basal progenitors, neocortex development
MeSH terms
Animals, Antimetabolites, Bromodeoxyuridine, Carrier Proteins, Cell Line, Cell Movement, Cell Nucleus, Cerebral Cortex, DNA, Female, Fetal Proteins, Immunohistochemistry, Microtubule-Associated Proteins, Microtubules, Neuroglia, Pregnancy, Transfection, Electroporation, Centrosome, Neocortex, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, Cell Proliferation, Mice, Neurogenesis, Neural Stem Cells

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