Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Yoshinori; Hashimoto, Osamu; Sanui, Terukazu; Oono, Takamasa; Koga, Hironori; Abe, Masaaki; Inayoshi, Ayumi; Noda, Mayuko; Oike, Masahiro; Shirai, Toshikazu; Sasazuki, Takehiko

doi:10.1038/35090591

Cited by 449Protein Kinase Regulation and GTPase SignalingChemokine receptors and signalingCell Adhesion Molecules Research

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Yoshinori, Hashimoto, Osamu, Sanui, Terukazu, Oono, Takamasa, Koga, Hironori, Abe, Masaaki, Inayoshi, Ayumi, Noda, Mayuko +3 more·2001·Nature

DOI 10.1038/35090591

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Abstract

Cell migration is a fundamental biological process involving membrane polarization and cytoskeletal dynamics, both of which are regulated by Rho family GTPases. Among these molecules, Rac is crucial for generating the actin-rich lamellipodial protrusion, a principal part of the driving force for movement. The CDM family proteins, Caenorhabditis elegans CED-5, human DOCK180 and Drosophila melanogaster Myoblast City (MBC), are implicated to mediate membrane extension by functioning upstream of Rac. Although genetic analysis has shown that CED-5 and Myoblast City are crucial for migration of particular types of cells, physiological relevance of the CDM family proteins in mammals remains unknown. Here we show that DOCK2, a haematopoietic cell-specific CDM family protein, is indispensable for lymphocyte chemotaxis. DOCK2-deficient mice (DOCK2-/-) exhibited migration defects of T and B lymphocytes, but not of monocytes, in response to chemokines, resulting in several abnormalities including T lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. In DOCK2-/- lymphocytes, chemokine-induced Rac activation and actin polymerization were almost totally abolished. Thus, in lymphocyte migration DOCK2 functions as a central regulator that mediates cytoskeletal reorganization through Rac activation.

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DOCK2 activates Rac but not Cdc42, whereas DOCK9 activates Cdc42 but not Rac.
“DOCK2 activates Rac but not Cdc42, whereas DOCK9 activates Cdc42 but not Rac (6,35,38).”
From Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors (2008) · cites this paper as [6]
The physiological activation of Rac by DOCK2 and DOCK180 requires their association with a regulatory protein ELMO1.
“Interestingly, the physiological activation of Rac by these GEFs requires their association with a regulatory protein ELMO1 (Engulfment and Motility) (6,33,34).”
From Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors (2008) · cites this paper as [6]

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Authors: Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T., & Sasazuki, T.
Affiliations: Kyushu University (JP)
Kurume University (JP)
Juntendo University (JP)
Corresponding author: Shirai, Toshikazu
ORCID: Fukui, Yoshinori
Hashimoto, Osamu
Sanui, Terukazu
Oono, Takamasa
Koga, Hironori
Abe, Masaaki
Sasazuki, Takehiko
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-08
Volume: 412
Issue: 6849
Pages: 826-831
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35090591
OpenAlex: W2022157262
Cited by: 449
References: 30
Citations by year: 2026: 6 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 10 · 2015: 12 · 2014: 23 · 2013: 21 · 2012: 22
FWCI: 8.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: University of Michigan
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: DOCK2, lymphocyte chemotaxis, lymphocyte migration, Rac activation, Rho GTPases, actin polymerization, cytoskeletal remodeling, T cells, B cells, marginal zone B cells, lymphopenia, chemokines
MeSH terms: Animals, B-Lymphocytes, Carrier Proteins, Cell Line, Chemotaxis, Leukocyte, Cytoskeleton, Female, Hematopoietic Stem Cells, Immunologic Memory, Male, Mice, Inbred C57BL, Spleen, Stem Cells, T-Lymphocytes, Cytokines, Chemokines, CXC, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein, Mice, Chemokine CXCL12

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Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

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