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Why we scratch an itch: the molecules, cells and circuits of itch
Open accessAbstract
Itch is described as an irritating sensation that triggers a desire to scratch. However, this definition hardly seems fitting for the millions of people who suffer from intractable itch. Indeed, the Buddhist philosopher Nā´áäāgārjuna more aptly stated, “There is pleasure when an itch is scratched. But to be without an itch is more pleasurable still.” Chronic itch is widespread and very difficult to treat. In this review we focus on the molecules, cells and circuits in the peripheral and central nervous systems that drive acute and chronic itch transmission. Understanding the itch circuitry is critical to developing new therapies for this intractable disease.
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Citations
Cited by
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
Oetjen, L. K., Mack, M. R., Feng, J., Whelan, T. M., Niu, H., Guo, C. J., Chen, S., Trier, A. M., Xu, A. Z., Tripathi, S. V., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.006 · Cited by 1,092
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Kardon, A. P., Polgár, E., Hachisuka, J., Snyder, L. M., Cameron, D., Savage, S., Cai, X., Karnup, S., Fan, C. R., Hemenway, G. M., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.046 · Cited by 369
Gate control of mechanical itch by a subpopulation of spinal cord interneurons
Bourane, S., Duan, B., Koch, S. C., Dalet, A., Britz, O., Garcia-Campmany, L., Kim, E., Cheng, L., Ghosh, A., Ma, Q., et al. (2015) · Science · doi:10.1126/science.aac8653 · Cited by 296
Metadata
- Authors
- Bautista, D. M., Wilson, S. R., & Hoon, M. A.
- Venue
- Nature Neuroscience
- Published
- 2014-01-28
- Volume
- 17
- Issue
- 2
- Pages
- 175-182
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2085720841
- Cited by
- 338
- References
- 0
- FWCI
- 35.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Bautista, D. M., Wilson, S. R., & Hoon, M. A. (2014). Why we scratch an itch: the molecules, cells and circuits of itch. Nature Neuroscience. https://doi.org/10.1038/nn.3619
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