Gate control of mechanical itch by a subpopulation of spinal cord interneurons
Open accessAbstract
A circuit controlling mechanical itch: Considerable progress has been made in understanding and treating chemically induced itch. However, little is known about the mechanisms underlying mechanically evoked itch. Bourane et al. produced a model of mechanical itch by reducing the number of neuropeptide Y–expressing inhibitory spinal interneurons. This led to a selective increase in mechanically evoked itch-like behavior in mice. In contrast, chemically evoked itch or pain behavior remained unaffected. Science , this issue p. 550
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The Npy dorsal inhibitory family comprised Inhib-12 and Inhib-13; studies suggest this family's markers identify neurons involved in mechanical itch and pain.
“The Npy dorsal, the inhibitory family was comprised of Inhib-12 and Inhib-13. Studies suggest this family’s markers identify neurons involved in mechanical itch and pain73,78,79.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [78]
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References 39 · Cited by 296
- Authors
- Bourane, S., Duan, B., Koch, S. C., Dalet, A., Britz, O., Garcia-Campmany, L., Kim, E., Cheng, L., Ghosh, A., Ma, Q., & Goulding, M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Harvard University (US)
- Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
- University of California San Diego (US)
- Corresponding author
- Bourane, Steeve
- Duan, Bo
- Ma, Qiufu
- Goulding, Martyn
- Venue
- Science
- Published
- 2015-10-30
- Volume
- 350
- Issue
- 6260
- Pages
- 550-554
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4700934
- OpenAlex
- W2177655369
- Cited by
- 296
- References
- 39
- Citations by year
- 2026: 25 · 2025: 17 · 2024: 21 · 2023: 21 · 2022: 30 · 2021: 31 · 2020: 45 · 2019: 26 · 2018: 32 · 2017: 27 · 2016: 19 · 2015: 2
- FWCI
- 19.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (NS086372, NS080586, NS072031, R01 NS 067216)
- Gatsby Charitable Foundation
- Caterina Foundation
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- spinal interneurons, neuropeptide Y, alloknesis, chronic pruritus, histamine-independent itch, gastrin-releasing peptide receptor, mechanoreceptors, dorsal horn, inhibitory interneurons, neuronal ablation
- MeSH terms
- Action Potentials, Animals, Hair, Interneurons, Mechanoreceptors, Mice, Transgenic, Neural Inhibition, Synaptic Transmission, Neuropeptide Y, Pruritus, Skin, Spinal Cord, Mechanotransduction, Cellular, Mice
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