GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Winkler, Ethan A, Nishida, Yoichiro, Sagare, Abhay P, Rege, Sanket V, Bell, Robert D, Perlmutter, David, Sengillo, Jesse D, Hillman, Sara +12 more·2015·Nature Neuroscience

DOI 10.1038/nn.3966

Cited by (682)

Items 201–300 of 682

MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1
Wenjing Liu, Heng Cai, Meiqing Lin, Lu Zhu, Lili Gao, Renjia Zhong, Siwei Bi, Yixue Xue, Xiuli Shang · 2016 · Experimental Cell Research
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways
Siva S. V. P. Sakamuri, Venkata N. L. R. Sure, Lahari Kolli, Wesley R Evans, Jared A Sperling, Gregory Jaye Bix, Xiaoying Wang, Dmitriy N Atochin, Walter L Murfee, Ricardo Mostany et al. · 2022 · Journal of Cerebral Blood Flow & Metabolism
Stroke-induced damage on the blood–brain barrier
Song Xue, Xin Zhou, Zhihui Yang, Xiang‐Kun Si, Xin Sun · 2023 · Frontiers in Neurology
The effect of aging on brain barriers and the consequences for Alzheimer’s disease development
Nina Gorlé, Caroline Van Cauwenberghe, Claude Libert, Roosmarijn E. Vandenbroucke · 2016 · Mammalian Genome
Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies
William M. Pardridge · 2016 · Expert Opinion on Biological Therapy
Diabetes‐induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain
Nikita Ved, Marlene E. Da Vitoria Lobo, Samuel M. Bestall, C. L. Vidueira, Nicholas Beazley‐Long, Kurt Ballmer‐Hofer, Masanori Hirashima, David O. Bates, Lucy Frances Donaldson, Richard P. Hulse · 2018 · The Journal of Physiology
Exercise, Arterial Stiffness, and Cerebral Vascular Function: Potential Impact on Brain Health
Jill Nicole Barnes, Andrew G. Pearson, Adam T. Corkery, Nicole A. Eisenmann, Kathleen B. Miller · 2021 · Journal of the International Neuropsychological Society
Impact of intestinal disorders on central and peripheral nervous system diseases
Yumna El-Hakim, Shameena Bake, Kathiresh Kumar Mani, Farida Sohrabji · 2022 · Neurobiology of Disease
The role of mitochondrial dysfunction in Alzheimer's disease: A potential pathway to treatment
Allison Bethanne Reiss, Saba Ahmed, Christopher Dayaramani, Amy D. Glass, Irving H. Gomolin, Aaron Pinkhasov, Mark M. Stecker, Thomas Wısnıewskı, Joshua De Leon · 2022 · Experimental Gerontology
The Blood-Brain Barrier
Weihong Pan, Abba J. Kastin · 2016 · The Neuroscientist
Neurovascular Ageing and Age-Related Diseases
Raj N. Kalaria, Yoshiki Hase · 2019 · Sub-cellular biochemistry/Subcellular biochemistry
Chronic cerebral hypoperfusion alters amyloid-β transport related proteins in the cortical blood vessels of Alzheimer’s disease model mouse
Jingwei Shang, Toru Yamashita, Feng Tian, Xianghong Li, Xia Liu, Xiaowen Shi, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Ryo Sasaki et al. · 2019 · Brain Research
Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer’s Disease Model Mice
Ruiqi Pang, Xiaofang Wang, Feifei Pei, Wei-Zeng Zhang, Jiaming Shen, Xiao-Qun Gao, Cheng Chang · 2019 · Journal of Alzheimer's Disease
Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease
Pamela V. Martino Adami, Celia Quijano, Natalia Magnani, Pablo Galeano, Pablo Evelson, Adriana Cassina, Sonia Do Carmo, María Celeste Leal, Eduardo Miguel Castaño, A. Claudio Cuello et al. · 2015 · Journal of Cerebral Blood Flow & Metabolism
The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
Xin Liu, Deren Hou, Fangbo Lin, Jing Luo, Jingwen Xie, Yan Wang, Yi Tian · 2018 · Reviews in the Neurosciences
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain
Kassandra Kisler, Divna Lazić, Melanie D. Sweeney, Shane Plunkett, Mirna El Khatib, Sergei A. Vinogradov, David A. Boas, Sava Sakadžić, Berislav V. Zloković · 2018 · Nature Protocols
Designing peptide nanoparticles for efficient brain delivery
Aroa Duro‐Castaño, Diana M. Leite, Joe Forth, Yangwei Deng, Diana Matias, Carlos Noble-Jesus, Giuseppe Battaglia · 2020 · Advanced Drug Delivery Reviews
Elevated CLOCK and BMAL1 contribute to the impairment of aerobic glycolysis from astrocytes in Alzheimer's disease
Yoo, Ik Dong, Park, Min Woo, Cha, Hyeon Woo, Yoon, Sunmi, Boonpraman, Napissara, Yi, Sun Shin, Moon, Jong-Seok · 2020 · International Journal of Molecular Sciences
Environmental lead exposure aggravates the progression of Alzheimer's disease in mice by targeting on blood brain barrier
Sai Wu, Huaixiang Liu, Heping Zhao, Xiaohui Wang, Jingli Chen, Dong Xia, Xiao Chen, Jianding Cheng, Zhiqiang Zhao, Yun He · 2019 · Toxicology Letters
Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles
Yamir Islam, Andrew G. Leach, Jayden A. Smith, Stefano Pluchino, Christopher R. Coxon, Muttuswamy Sivakumaran, James R. Downing, Amos A. Fatokun, Meritxell Teixidò, Touraj Ehtezazi · 2021 · Advanced Science
Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet
Seiryo Ogata, Shingo Ito, Takeshi Masuda, Sumio Ohtsuki · 2019 · Pharmaceutical Research
High-fat diet impairs cognitive function of zebrafish
Shinichi Meguro, Sayaka Hosoi, Takahiro Hasumura · 2019 · Scientific Reports
Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice
Saifudeen Ismael, Sanaz Nasoohi, Arum Yoo, Heba A. Ahmed, Tauheed Ishrat · 2020 · Molecular Neurobiology
Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice
Ying Chen, Jin Deok Joo, John Man Tak Chu, Raymond Chuen‐Chung Chang, Gordon Tin Chun Wong · 2023 · Journal of Neuroinflammation
Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis
Carlos G. Ardanaz, Aida de la Cruz, Paras Singh Minhas, Nira Hernández‐Martín, Miguel Angel Pozo, M. Pilar Valdecantos, Ángela M. Valverde, Palmira Villa, Marcos Elizalde-Horcada, Elena Puerta et al. · 2024 · Science Advances
Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases
Yiyi Zhu, Alexei Verkhratsky, Hui Chen, Chenju Yi · 2025 · Acta Physiologica
Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice
Huazhen Qin, Yu Jiang, Jian Zhang, Chao Deng, Zhiyuan Zhong · 2019 · Molecular Pharmaceutics
Quantitative PET imaging and modeling of molecular blood-brain barrier permeability
Kevin J. Chung, Yasser G. Abdelhafez, Benjamin A. Spencer, Terry Jones, Tran Nhan Tam Quyen, Lorenzo Nardo, Moon S. Chen, Souvik Sarkar, Valentina Medici, Victoria Lyo et al. · 2025 · Nature Communications
Brain Vascular Imaging Techniques
Bàrbara Laviña · 2016 · International Journal of Molecular Sciences
Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell‐Derived Brain Endothelial Cells
Matthew J. Stebbins, Ethan S. Lippmann, Madeline G. Faubion, Richard Daneman, Sean P. Palecek, Eric V. Shusta · 2017 · Biotechnology Journal
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Ana Isabel Duarte, Maria S. Santos, Catarina Resende Oliveira, Paula Isabel Moreira · 2018 · Neuropharmacology
The multi-faceted impact of methamphetamine on Alzheimer's disease: From a triggering role to a possible therapeutic use.
M. Shukla, B. Vincent · 2020 · Ageing Research Reviews
Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases
Debashish Paramanick, Veena Devi Singh, Vijay Kumar Singh · 2022 · Journal of Controlled Release
Near‐critical GLUT1 and Neurodegeneration
L. Felipe Barros, Alejandro San Martín, Iván Ruminot, Pamela Y. Sandoval, Ignacio Fernández‐Moncada, Felipe Baeza‐Lehnert, Robinson Arce‐Molina, Yasna Contreras‐Baeza, Francisca Cortés‐Molina, Alex Galaz et al. · 2017 · Journal of Neuroscience Research
The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling
Dianaly T. Au, Dudley K. Strickland, Selen C. Muratoglu · 2017 · Journal of Diabetes Research
Epigenetics in blood–brain barrier disruption
Stephanie A. Ihezie, Iny Elizebeth Mathew, Devin William McBride, Ari Dienel, Spiros Blackburn, Peeyush Kumar Thankamani Pandit · 2021 · Fluids and Barriers of the CNS
Astrocyte in Neurological Disease: Pathogenesis and Therapy
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang · 2025 · MedComm
Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Mikko Gynther, Elena Puris, Soile Peltokangas, Seppo O. K. Auriola, Katja M. Kanninen, Jari Koıstınaho, Kristiina M. Huttunen, Marika Ruponen, Kati‐Sisko Vellonen · 2018 · Pharmaceutical Research
Drugs Modulating CD4+ T Cells Blood–Brain Barrier Interaction in Alzheimer’s Disease
Norwin Kubick, Patrick C. Henckell Flournoy, Ana‐Maria Enciu, Michel‐Edwar Mickael, Gina Manda · 2020 · Pharmaceutics
Cell type-specific potential pathogenic genes and functional pathways in Alzheimer’s Disease
Xiaolan Wang, Lianjian Li · 2021 · BMC Neurology
A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies
Daniela Jaime García, Audrey Chagnot, Joanna Marguerite Wardlaw, Axel Montagne · 2023 · International Journal of Molecular Sciences
The blood-brain barrier, a key bridge to treat neurodegenerative diseases
Zhongci Hang, Liping Zhou, Cencan Xing, Yongqiang Wen, Hongwu Du · 2023 · Ageing Research Reviews
Lower GLUT1 and unchanged MCT1 in Alzheimer’s disease cerebrovasculature
Manon Leclerc, Cyntia Tremblay, Philippe Bourassa, Julie A. Schneider, David Alan Bennett, Frédéric Calon · 2024 · Journal of Cerebral Blood Flow & Metabolism
Characterization of Impaired Cerebrovascular Structure in APP/PS1 Mouse Brains
Kee-Chan Ahn, Cameron R. Learman, Gary Leo Dunbar, Panchanan Maiti, Won‐Cheoul Jang, Hyeon Cheol, Mee-Sook Song · 2018 · Neuroscience
Microphysiological systems for recapitulating physiology and function of blood-brain barrier
Su‐Yeong Seo, Hwieun Kim, Jong Hwan Sung, Nakwon Choi, Kangwon Lee, Hong Nam Kim · 2019 · Biomaterials
Alteration in the Function and Expression of SLC and ABC Transporters in the Neurovascular Unit in Alzheimer’s Disease and the Clinical Significance
Yongming Jia, Na Wang, Yingbo Zhang, Di Xue, Haoming Lou, Xue‐Wei Liu · 2020 · Aging and Disease
D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI
Lin Chen, Zhiliang Wei, Kannie W. Y. Chan, Yuguo Li, Kapil Suchal, Sheng Bi, Jianpan Huang, Xiang Xu, Philip C. Wong, Hanzhang Lu et al. · 2020 · Journal of Cerebral Blood Flow & Metabolism
Regional cerebral hypometabolism on 18F‐FDG PET/CT scan in delirium is independent of acute illness and dementia
Anita Nitchingham, Jarett Vanz‐Brian Pereira, Eva Alina Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan · 2022 · Alzheimer s & Dementia
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases
Rachel C. Knopp, Michelle A. Erickson, Elizabeth M. Rhea, May J. Reed, William A. Banks · 2023 · Experimental Biology and Medicine
Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment
Ferenc Deák, Willard M. Freeman, Zoltan I. Ungvari, Anna Csiszár, William Edmund Sonntag · 2015 · The Journals of Gerontology Series A
Nurr1 Modulation Mediates Neuroprotective Effects of Statins
Sabine Willems, Julian Aurelio Marschner, Whitney Kilu, Giuseppe Faudone, Romy Busch, Silke Duensing‐Kropp, Jan Heering, Daniel Merk · 2022 · Advanced Science
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice
Shaoyu Zhou, Feng Jie Jin, Fei Yan, Ju Liu, Meixiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Dan Jin, Jing Nie, Xiao-Long Fu et al. · 2022 · Neural Regeneration Research
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
Jana, Arundhati, Wang, Xinge, Leasure, Joseph W., Magana, Lissette, Wang, Li, Kim, Young-Mee, Dodiya, Hemraj, Toth, Peter T., Sisodia, Sangram S., Rehman, Jalees · 2022 · Scientific Reports
Targeting Transferrin Receptor 1 for Enhancing Drug Delivery Through the Blood–Brain Barrier for Alzheimer’s Disease
Xiaoxia Shen, Huan Li, Beiyu Zhang, Yunan Li, Zheying Zhu · 2025 · International Journal of Molecular Sciences
Paving the Way Toward Complex Blood-Brain Barrier Models Using Pluripotent Stem Cells
Karin Lauschke, Lise Frederiksen, Vanessa Jane Hall · 2017 · Stem Cells and Development
Brain Endothelial Cells in Blood–Brain Barrier Regulation and Neurological Therapy
Yuqing Xiang, Qiuxiang Gu, Dong Liu · 2025 · International Journal of Molecular Sciences
Alzheimer’s Disease as the Product of a Progressive Energy Deficiency Syndrome in the Central Nervous System: The Neuroenergetic Hypothesis
Edward R. Blonz · 2017 · Journal of Alzheimer s Disease
The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics
Cristina de la Torre, Valentı́n Ceña · 2018 · Pharmaceutics
Lipid-Binding Proteins in Brain Health and Disease
Miriam Corraliza-Gómez, Diego Sánchez, María Dolores Ganfornina · 2019 · Frontiers in Neurology
Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro
Snehal Raut, Ronak Patel, Abraham Jacob Al-Ahmad · 2021 · Fluids and Barriers of the CNS
Glut1 deficiency syndrome: New and emerging insights into a prototypical brain energy failure disorder
Maoxue Tang, Umrao R. Monani · 2021 · Neuroscience Insights
Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon‐like peptide‐1 receptor agonists
Hussein N. Yassine, Victoria A. Solomon, Angad Thakral, Nasim Sheikh‐Bahaei, Helena Chang Chui, Meredith N. Braskie, Lon S. S. Schneider, Konrad Talbot · 2021 · Alzheimer s & Dementia
Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings
Mohammad Rafi Khezri, Keyvan Yousefi, Negin Mahboubi, Darya Hodaei, Morteza Ghasemnejad‐Berenji · 2022 · Biochemical Pharmacology
Metabolic Defects Caused by High-Fat Diet Modify Disease Risk through Inflammatory and Amyloidogenic Pathways in a Mouse Model of Alzheimer’s Disease
Austin M. Reilly, Andy Po‐Yi Tsai, Peter Bor‐Chian Lin, Aaron C. Ericsson, Adrian L. Oblak, Hongxia Ren · 2020 · Nutrients
Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation
Marine Tournissac, Manon Leclerc, Josue Valentin‐Escalera, Milène Vandal, Cristina R. Bosoi, Emmanuel Planel, Frédéric Calon · 2021 · Ageing Research Reviews
Does hyperglycemia downregulate glucose transporters in the brain?
Luana Lemos Leão, Gro Gujord Tangen, Maria Lage Barca, Knut Engedal, Sérgio Henrique Sousa Santos, Frederico Sander Mansur Machado, Alfredo Maurício Batista de Paula, Renato Sobral Monteiro-Júnior · 2020 · Medical Hypotheses
Historical and current perspectives on blood endothelial cell heterogeneity in the brain
Ryota L. Matsuoka, Luke D. Buck, Keerti P. Vajrala, Rachael E. Quick, Olivia A. Card · 2022 · Cellular and Molecular Life Sciences
Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease
Goran Šimić, Ena Španić, Lea Langer Horvat, Patrick R. Hof · 2019 · Progress in molecular biology and translational science
An early endothelial cell–specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice
Maoxue Tang, Sarah H. Park, Sabrina Petri, Hang Yu, Carlos B. Rueda, E. Dale Abel, Carla Y. Kim, Elizabeth M. C. Hillman, Fanghua Li, Yeojin Lee et al. · 2020 · JCI Insight
Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway
Daniel Rand, Orly Ravid, Dana Atrakchi, Hila Israelov, Yael Bresler, Chen Shemesh, Liora Omesi, Sigal Liraz Zaltsman, Fabien Gosselet, Taber S. Maskrey et al. · 2021 · Pharmaceutics
cAMP Compartmentalization in Cerebrovascular Endothelial Cells: New Therapeutic Opportunities in Alzheimer’s Disease
Dolores Viña, Nuria Seoane, Elisardo C. Vasquez, Manuel Campos‐Toimil · 2021 · Cells
Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders
Callan D. McLoughlin, Sarah Nevins, Joshua B. Stein, Mehrdad Khakbiz, Ki‐Bum Lee · 2024 · Small Science
Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke
Laetitia Thieren, Henri S. Zanker, Jeanne Droux, Urvashi Dalvi, Matthias Tasso Wyss, Rebecca Waag, Pierre‐Luc Germain, Lukas von Ziegler, Zoe J. Looser, Ladina Hösli et al. · 2025 · Nature Communications
Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells
Abraham Jacob Al-Ahmad · 2017 · American Journal of Physiology-Cell Physiology
Oxidative Stress in the Pathogenesis of Alzheimer's Disease and Cerebrovascular Disease with Therapeutic Implications
Anamaria Jurcău, Aurel Simion · 2020 · CNS & Neurological Disorders - Drug Targets
Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders
Ajay R. Uprety, Yeji Kang, Soo Young Kim · 2021 · Archives of Pharmacal Research
Astrocytic microRNAs and transcription factors in Alzheimer’s disease and therapeutic interventions
Nassar, Ajmal, Kodi, Triveni, Satarker, Sairaj, Chowdari Gurram, Prasada, Upadhya, Dinesh, SM, Fayaz, Mudgal, Jayesh, Nampoothiri, Madhavan · 2022 · Cells
Epigenetic regulation of the glucose transporter geneSlc2a1by β‐hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice
Kosuke Tanegashima, Yukiko Sato‐Miyata, Masabumi Funakoshi, Yasumasa Nishito, Toshiro Aigaki, Takahiko Hara · 2016 · Genes to Cells
ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells
Hu Zhang, Shuhong Zhang, Jilin Zhang, Dongxin Liu, Jiayi Wei, Wen‐Gang Fang, Wei‐Dong Zhao, Yuhua Chen, De‐Shu Shang · 2017 · Journal of Cerebral Blood Flow & Metabolism
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells
Jiyeon Lee, Haeryung Lee, Hyein G. Lee, Miram Shin, Min-Gi Shin, Jinsoo Seo, Eun Jeong Lee, Sun Ah Park, Soochul Park · 2023 · Nature Communications
The Beneficial Role of Exercise on Treating Alzheimer’s Disease by Inhibiting β-Amyloid Peptide
Zixuan Tan, Fang Dong, Linyu Wu, Ya-Shuo Feng, Feng Zhang · 2021 · Molecular Neurobiology
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Nimrod Madrer, Nirma D. Perera, Nonthué Alejandra Uccelli, Alice Abbondanza, Jens Velde Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi et al. · 2025 · Journal of Neurochemistry
α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
Yanhui Zhang, Xin-zhu Yan, Shuangfeng Xu, Zhongqiu Pang, Linbo Li, Yang Yang, Yonggang Fan, Zhuo Wang, Xin Yu, Chuang Guo et al. · 2020 · Frontiers in Aging Neuroscience
Astrocytes as Neuroimmunocytes in Alzheimer’s Disease: A Biochemical Tool in the Neuron–Glia Crosstalk along the Pathogenetic Pathways
Stefano Stanca, Martina Rossetti, Paolo Bongioanni · 2023 · International Journal of Molecular Sciences
Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: Common Molecular Mechanism and Therapeutic Targets
Aparna Chauhan, Sachin Dubey, Smita Jain · 2024 · Cell Biochemistry and Function
Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP + cells loss induced by restraint stress in mice
Nelson Perez-Urrutia, Cristhian Mendoza, Nathalie Alvarez-Ricartes, Patricia Oliveros-Matus, Florencia Echeverria, J. Alex Grizzell, George Emilio Barreto, Alexandre Iarkov, Valentina Echeverrı́a · 2017 · Experimental Neurology
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
Choy Ker Woon, Wong Kah Hui, Razif Abas, Muhammad Huzaimi Haron, Srijit Das, Teoh Seong Lin · 2021 · Current Neuropharmacology
Multifocal Cerebral Microinfarcts Modulate Early Alzheimer’s Disease Pathology in a Sex-Dependent Manner
Sarah Lecordier, Vincent Pons, Serge Rivest, Ayman ElAli · 2022 · Frontiers in Immunology
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice
Shuangxue Han, Zhijun He, Xia Hu, Xiaoqian Li, Kaixin Zheng, Yingying Huang, Peng Xiao, Qingguo Xie, Jiazuan Ni, Qiong Liu · 2023 · Antioxidants
Risk factors, preventive interventions, overlapping symptoms, and clinical measures of delirium in elderly patients
Xi Mei, Yuehong Liu, Ya-Qing Han, Chengying Zheng · 2023 · World Journal of Psychiatry
The emerging role of brain neuroinflammatory responses in Alzheimer’s disease
Mandana AmeliMojarad, Melika AmeliMojarad, Xiaonan Cui · 2024 · Frontiers in Aging Neuroscience
Alzheimer amyloid-β- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood
Hendrix, Rachel D., Ou, Yang, Davis, Jakeira E., Odle, Angela K., Groves, Thomas R., Allen, Antiño R., Childs, Gwen V., Barger, Steven W. · 2021 · Neurobiology of Aging
Strategies and materials of "SMART" non-viral vectors: Overcoming the barriers for brain gene therapy
Yan Li, Linying Liu, Weihong Ji, Huang Peng, Ruichen Zhao, Xin Zhang · 2020 · Nano Today
The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
Susana Santos Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho et al. · 2021 · Journal of Neuroinflammation
Sugar and Alzheimer's disease: a bittersweet truth
Costantino Iadecola · 2015 · Nature Neuroscience
Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease
Ting Lei, Zixiao Yang, Hanmei Li, Meng Qin, Huile Gao · 2024 · Advanced Drug Delivery Reviews
Senescence-associated microvascular endothelial dysfunction: A focus on the blood-brain and blood-retinal barriers
Sung Young Kim, Jaejoung Cheon · 2024 · Ageing Research Reviews
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter
Pavitra Kannan, Martin Schain, Warren W. Kretzschmar, Lora D. Weidner, Nicholas Mitsios, Balázs Zoltán Gulyás, Hans Blom, Michael M. Gottesman, Robert B. Innis, Matthew D. Hall et al. · 2016 · Journal of Cerebral Blood Flow & Metabolism
G Protein-Coupled Receptors in the Mammalian Blood-Brain Barrier
Brock R. Pluimer, Mark Colt, Zhen Zhao · 2020 · Frontiers in Cellular Neuroscience
Senescence and associated blood–brain barrier alterations in vitro
Ellaine Salvador, Małgorzata Burek, Mario Löhr, Michiaki Nagai, Carsten Hagemann, Carola Yvette Förster · 2021 · Histochemistry and Cell Biology