GDF10 is a signal for axonal sprouting and functional recovery after stroke

Li, Songlin, Nie, Esther H, Yin, Yuqin, Benowitz, Larry I, Tung, Spencer, Vinters, Harry V, Bahjat, F Rena, Stenzel-Poore, Mary P +3 more·2015·Nature Neuroscience

Cited by (181)

Items 101–181 of 181

  1. CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
    Ying Bai, Hui Ren, Shuo Leng, Mengqin Yuan, YiXin Jiang, Shenyang Zhang, Yu Wang, Minzi Ju, Zhi Wang, Xi Wen et al. · 2025 · Cellular and Molecular Immunology
  2. TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6
    Julia Kaiser, Martina A. Maibach, Ester Piovesana, Iris Salpeter, Nora A. Escher, Yannick Ormen, Martin E. Schwab · 2020 · eNeuro
  3. Whole transcriptome approach to evaluate the effect of aluminium hydroxide in ovine encephalon
    Endika Varela-Martínez, Martin Bilbao‐Arribas, Naiara Abendaño · 2020 · Scientific Reports
  4. EPO promotes axonal sprouting via upregulating GDF10
    Sijia Li, Kefei Cui, Jia-jia Fu, Xiaojie Fu, Yufeng Gao, Di Zhang, Zhengfang Lu, Yongxin Zhang, Lie Yu, Jianping Wang · 2019 · Neuroscience Letters
  5. Dual effect of C-C motif chemokine receptor 5 on ischemic stroke: More harm than benefit?
    Kai Jing, Feng Chen, Xiao-Fei Shi, Jin-Min Guo, Xia Liu · 2023 · European Journal of Pharmacology
  6. Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression
    Seog‐Kyun Mun, Kyuhee Han, Jong Tae Baek, Suk‐Won Ahn, Hyun Sang Cho, Mun Young Chang · 2018 · Clinical and Experimental Otorhinolaryngology
  7. miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN
    Lijing Li, Penghua Cui, Huimin Ge · 2020 · Experimental and Molecular Pathology
  8. Lesion Area in the Cerebral Cortex Determines the Patterns of Axon Rewiring of Motor and Sensory Corticospinal Tracts After Stroke
    Tokiharu Sato, Yuka Nakamura, Akinori Takeda, Masaki Ueno · 2021 · Frontiers in Neuroscience
  9. Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure
    Kyuhee Han, Seog‐Kyun Mun, Seonyong Sohn, Xian‐Yu Piao, Ilyong Park, Mun Young Chang · 2019 · International Journal of Molecular Medicine
  10. New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury
    Dominique Lemaitre, Felipe A. Court · 2021 · Neural Regeneration Research
  11. Learning and Stroke Recovery: Parallelism of Biological Substrates
    Mary Teena Joy, Stanley Thomas Carmichael · 2021 · Seminars in Neurology
  12. Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke
    Nicolás García-Rodríguez, Miguel García‐Gabilondo, Susana Rodrı́guez, Pedro Ignacio Tejada, Zuberoa Maite Miranda-Artieda, Natàlia Ridao, Xavier Buxó, María Engracia Pérez-Mesquida, Maria Rosario Beseler, Juan B. Salom et al. · 2025 · Scientific Reports
  13. Nanoparticle-Mediated Nose-to-Brain Delivery for Ischemic Stroke Therapy: Preclinical Insights
    Joonhyuck Park, Tae‐Ryong Riew · 2025 · Pharmaceutics
  14. DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke
    Tian‐Jie Lyu, Xin Ye Qiu, Yübo Wang, Ling Zhang, Yalun Dai, Xuechun Wang, Shunying Zhao, Meilin Xiang, Lu Cui, Si Cheng et al. · 2024 · MedComm
  15. Restoring neuro-immune circuitry after brain and spinal cord injuries
    Masaki Ueno · 2021 · International Immunology
  16. The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia
    Stanley Thomas Carmichael, Irene Lorenzo Llorente · 2022 · Neurotherapeutics
  17. The Finer Aspects of Grid-Walking and Cylinder Tests for Experimental Stroke Recovery Studies in Mice
    Nausheen Syeara, Sounak Bagchi, Abdullah Al Shoyaib, Serob T. Karamyan, Faisal F. Alamri, Vardan T. Karamyan · 2023 · Methods in molecular biology
  18. Multilevel assessment of carbamazepine effects: An integrative approach using zebrafish early-life stages
    Muriel Lopes da Silva, Thayres S. Andrade, Rolando André Rios Villacis, Diego Sousa-Moura, Inês Domingues, Carolina Almeida Lisboa, Níchollas Serafim Camargo, Aline Pic‐Taylor, Rhaul Oliveira, César Koppe Grisólia · 2024 · Chemosphere
  19. Bone Morphogenetic Protein (BMP)-3b Gene Depletion Causes High Mortality in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
    Yuko Ogawa, Masahiro Tsuji, Emi Tanaka · 2018 · Frontiers in Neurology
  20. Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats
    Claire Deckers, Reza Karbalaei, Nylah A. Miles, Eden V. Harder, Emily Witt, Erin P. Harris, Kathryn J. Reissner, Mathieu E. Wimmer, Debra A. Bangasser · 2024 · Neurobiology of Stress
  21. Considering Context-Specific microRNAs in Ischemic Stroke with Three “W”: Where, When, and What
    Chuheng Chang, Youyang Wang, Renzhi Wang, Xinjie Bao · 2024 · Molecular Neurobiology
  22. Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation
    Gerardo Ávila-Martín, Manuel Mata, Iriana Galán-Arriero, Julian Taylor, Xavier Busquets, Pablo V. Escribá · 2017 · PLoS ONE
  23. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation
    Long Jiang, Botao Tan, Sen Li · 2017 · Neuroreport
  24. Genome-wide characterization of the TGF-β gene family and their expression in different tissues during tail regeneration in the Schlegel's Japanese gecko Gekko japonicus
    Qian Liu, Ru‐Meng Zhao, Danyan Wang, Peng Li, Yan‐Fu Qu, Xiang Ji · 2023 · International Journal of Biological Macromolecules
  25. Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke
    Dongyeong Yoon, Min‐Tae Jeon, Kim Dong Woon, Sang Ryong Kim · 2020 · Neuroreport
  26. Transcriptomic alterations in cortical astrocytes following the development of post-traumatic epilepsy
    Leonard, John, Wei, Xiaoran, Browning, Jack, Gudenschwager-Basso, Erwin Kristobal, Li, Jiangtao, Harris, Elizabeth A., Olsen, Michelle L., Theus, Michelle H. · 2024 · Scientific Reports
  27. Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions
    Ankit Kumar Singh, Khalandar Dhalayat, Shradheya V. Dhobale, Bijoyani Ghosh, Aishika Datta, Anupom Borah, Pallab Bhattacharya · 2025 · Ageing Research Reviews
  28. Acute Transcriptomic and Epigenetic Alterations at T12 After Rat T10 Spinal Cord Contusive Injury
    Junkai Xie, Seth Herr, Donghan Ma, Shichen Wu, Han Zhao, Siyuan Sun, Zhixiong Ma, Matthew Yan-lok Chan, Katherine T Li, Yang Yang et al. · 2023 · Molecular Neurobiology
  29. Long-range axon branching: contributions to brain network plasticity and repair
    Linda J. Richards, Cheng Huang, Adam Q. Bauer, Jin‐Moo Lee · 2026 · Nature reviews. Neuroscience
  30. Osteopontin-integrin signaling positively regulates neuroplasticity through enhancing neural autophagy in the peri-infarct area after ischemic stroke.
    Haikang Liao, Zhenyou Zou, Weiqin Liu, Xuefeng Guo, Jinlu Xie, Liangxian Li, Xia Li, Xinying Gan, Xiansheng Huang, Juxia Liu et al. · 2022 · PubMed Central
  31. Effect of dexmedetomidine on ncRNA and mRNA profiles of cerebral ischemia-reperfusion injury in transient middle cerebral artery occlusion rats model
    Zhen Zhen Zhang, Abdul Nasır, Dong Li, Suliman Khan, Qian Bai, Feng Yuan · 2024 · Frontiers in Pharmacology
  32. SFXN1 Reduction Alleviates Cerebral Ischemia–Reperfusion Injury by Promoting Neuronal Survival and Reducing Neuroinflammation
    Xiangyu Xu, Zhongying Duan, Xin Zhou · 2025 · CNS Neuroscience & Therapeutics
  33. Chemogenetic activation of astrocytic Gi signaling promotes spinogenesis and motor functional recovery after stroke
    Chaoran Wu, Yu Li, Xinran He, Hao Sun, Shiwen Zhang, Fengsheng Hou, Mengqiu Hu, Aili Lan, Hao Zhang, Qi Long et al. · 2024 · Glia
  34. S‐Nitrosylation of Dexras1 Controls Post‐Stroke Recovery via Regulation of Neuronal Excitability and Dendritic Remodeling
    Zhou Han, Yixuan Song, Cheng Qin, Hai-Hui Zhou, Dan Han, Simin Yan, Huanyu Ni · 2025 · CNS Neuroscience & Therapeutics
  35. Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis
    Yinliang Zhang, Xiaochen Gai, Yuhui Li, Zuoyu Chen, Xi Zhang, Wei Qiao, Ping Qiu, Chunyuan Du, Sufang Sheng, Jingran Hao et al. · 2025 · Advanced Science
  36. The protective effect of erythropoietin and its novel derived peptides in peripheral nerve injury
    Guixian Liu, Jie Liang, Wei Li, Suli Jiang, Meiying Song, Shuo Xu, Qiaochu Du, Luoyang Wang, Xiao Wang, Xiaoli Liu et al. · 2024 · International Immunopharmacology
  37. Activation of GABA A receptors enhances the behavioral recovery but not axonal sprouting in ischemic rats
    Huibin Wang, Xi Cheng, Hang Yu, Xiuchun Zhang, Meiting Guan, Lanqing Zhao, Yang Liu, Yifan Linag, Yujia Luo, Chuansheng Zhao · 2019 · Restorative Neurology and Neuroscience
  38. Comprehensive Analysis of GDF10 Methylation Site-Associated Genes as Prognostic Markers for Endometrial Cancer
    Jingyi Fan, Huaijun Zhou · 2022 · Journal of Oncology
  39. GDF10 is a negative regulator of vascular calcification
    Khrystyna Platko, Gabriel Gyulay, Paul F. Lebeau, Melissa E. MacDonald, Edward G. Lynn, Jae Hyun Byun, Suleiman A. Igdoura, Rachel Mary Holden, Anna Roubtsova, Nabil Georges Seidah et al. · 2024 · Journal of Biological Chemistry
  40. From symmetry to chaos and back: Understanding and imaging the mechanisms of neural repair after stroke
    Caroline Alionte, Christian Notte, Christos D. Strubakos · 2021 · Life Sciences
  41. Unilateral Spatial Neglect without Hemiplegia: The Output-Mode Effect Revisited
    Shay Ofir, Corinne Serfaty, Yaron Sacher · 2021 · Journal of Stroke and Cerebrovascular Diseases
  42. Transforming growth factor-β1 protects mechanically injured cortical murine neurons by reducing trauma-induced autophagy and apoptosis
    Yanlei Li, Huixiong Deng, Hengyao Zhang, Lin Yang, Shenmiao Wang, Haoyang Wang, Jiacheng Zhu, Xiaoning Li, Xiaoxuan Chen, Yinhong Lin et al. · 2024 · Frontiers in Cellular Neuroscience
  43. GDF10 spurs on axonal sprouting after stroke
    Katie Kingwell · 2015 · Nature Reviews Drug Discovery
  44. No evidence for motor recovery-related cortical reorganization after stroke using resting-state fMRI
    Meret Branscheidt, Naveed Ejaz, Jing Xu, Mario Widmer, Michelle D. Harran, Juan Camilo Cortés, Tomoko Kitago, Pablo A. Celnik, Carlos Roberto Hernandez-Castillo, Jörn Diedrichsen et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  45. GDF10 exacerbates metastatic burden and cachexia in murine models of cancer
    Lauren S. James, Alastair A. E. Saunders, Chris Karagiannis, Hongwei Qian, Robin L. Anderson, Rachel E. Thomson, Craig A. Goodman, Paul Gregorevic · 2026 · Frontiers in Physiology
  46. A Low-Budget Photothrombotic Rodent Stroke Model
    Faisal F. Alamri, Serob T. Karamyan, Vardan T. Karamyan · 2023 · Methods in molecular biology
  47. Rodent Stroke Models to Study Functional Recovery and Neural Repair
    Daimen R. S. Britsch, Nausheen Syeara, Ann Marie Stowe, Vardan T. Karamyan · 2023 · Methods in molecular biology
  48. Mechanism of Post-stroke Axonal Outgrowth and Functional Recovery
    Yuji Ueno · 2023 · Juntendō Igaku/Juntendo igaku
  49. Research status and future perspectives of IL-27 in the treatment of stroke (Review)
    Wei-Qin Liu, Zhenyou Zou, Wen-Yang Li, Guang Yang, Jie Zhang, Zhen-Yu Zhang, Hua Yao · 2025 · International Journal of Molecular Medicine
  50. Homonymous hemianopsia versus unilateral spatial neglect rehabilitation strategies in stroke patients
    Adriana Elena Bulboacă, Angelo Bulboacă, Ioana Stănescu · 2019 · Balneo Research Journal
  51. Quantitative Spatial Mapping of Axons Across Cortical Regions to Assess Axonal Sprouting After Stroke
    Mary Teena Joy, Samuel P. Bridges, Stanley Thomas Carmichael · 2023 · Methods in molecular biology
  52. Brain Recovery in Childhood: The Interaction Between Developmental Plasticity and Regenerative Mechanisms
    Floriana Costanzo, Elisa Fucà, Deny Menghini, Stefano Vicari · 2023 · Contemporary clinical neuroscience
  53. MicroRNA- 3135b as a Therapeutic Target and Clinical Biomarker for Stroke: Regulation of the NF-κB/IKKβ Signaling Pathway
    Shaobo Liu, Qiang He, Nana Zhang, Yongbiao Li, Qingshan Liu · 2025 · Molecular Neurobiology
  54. Targeting Brain Networks for Recovery: Multimodal Innovations in Poststroke Therapy
    Shahrzad Latifi · 2026 · Stroke
  55. Integrating Molecular, Cellular, and Systems Approaches to Repairing the Brain After Stroke
    Max Ostrinsky Krucoff, Stephen C. Harward, Shervin Rahimpour, Keith E. Dombrowski, Erik Friedrich Hauck, Shivanand Pramod Lad, Dennis A. Turner · 2017 · Springer series in translational stroke research
  56. Current Implantable Devices in Human Neurological Surgery
    Raquel Madroñero-Mariscal, Ana de los Reyes-Guzmán, Fernando García-García, Antonio García Peris, J. L. Polo, Ángel Rodríguez de Lope, Elisa López‐Dolado · 2021 · Springer eBooks
  57. Accurate estimation of stroke risk with fuzzy clustering and ensemble learning methods
    Anıl Akyel · 2022 · Biomedical Signal Processing and Control
  58. Asporin and CD109, expressed in the injured neonatal spinal cord, attenuate axonal re-growth in vitro
    Sakura Hosen, Iyo Ikeda-Yorifuji, Toshihide Yamashita · 2024 · Neuroscience Letters
  59. Decoding the causal drivers of spatial cellular topology
    Prannav Shankar, Huan Liang, Uthsav Chitra, Rohit Singh · 2026 · iScience
  60. Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer
    Minjie Zhu, Jiawei Hong, Xian‐Fang Liu, Haiming Wang, Longquan Lou · 2025 · Medicine
  61. The Neurovascular Unit
    Eng H. Lo · 2017 · Primer on Cerebrovascular Diseases
  62. Augmenting Plasticity and Recovery from Stroke by Modulating the Extracellular Matrix of the Central Nervous System
    Anna M Wiersma · 2017 · ERA: Education and Research Archive (University of Alberta)
  63. Ischemia promotes hypertrophic nerve trunk formation and enteric neuron cell death in Hirschsprung’s disease
    Deshu Xu, Weiwei Liang, Chaoting Lan, Lanying Li, Weiyong Zhong, Meng Yao, Xiaoyu Zuo, Jixiao Zeng, Wei Zhong, Qiang Wu et al. · 2024 · medRxiv
  64. Characterization of Spontaneous Motor Recovery and Changes in Plasticity-Limiting Perineuronal Nets Following Cortical and Subcortical Stroke
    Sai Sudarshan Karthikeyan · 2017 · uO Research (University of Ottawa)
  65. Structural Neural Plasticity During Stroke Recovery * *This work was supported by operating, salary, and equipment grants to C.E.B. from CIHR, Heart and Stroke Foundation of BC and Yukon, MSFHR, NSERC, and CFI.
    Kimberly Gerrow, Craig E. Brown · 2017 · Elsevier eBooks
  66. Axonal outgrowth and functional recovery after stroke
    Yuji Ueno, Ryota Tanaka, Takao Urabe, Nobutaka Hattori · 2018 · Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
  67. Faculty Opinions recommendation of A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
    Phillip G. Popovich · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  68. Thyroid Hormone-Regulated Genes in the Brain
    Juan Bernal · 2024 · BENTHAM SCIENCE PUBLISHERS eBooks
  69. Mechanisms underlying the spontaneous reorganization of depression network after stroke
    Yirong Fang, Xian Chao, Zeyu Lu, Hongmei Huang, Ran Shi, Dawei Yin, Hao Chen, Yanan Lu, Jinjing Wang, Peng Wang et al. · 2024 · NeuroImage Clinical
  70. Neurorehabilitation in children neurorehabilitation in children with cerebrovascular insult: Why are we late?
    Hristina Čolović, Dragan Zlatanović, Vesna D. Zivkovic · 2023 · AFMN Biomedicine
  71. Axon regeneration after spinal cord and brain injuries
    Madeline Rose McCrea, Shuxin Li · 2025 · Elsevier eBooks
  72. Rejuvenation of corticospinal neurons enhances rehabilitation-associated corticospinal tract axon sprouting and functional recovery post photothrombotic ischemic stroke in mice
    Bin Sun, Li Sun, Lixiang Zhang, Xinyu Xue, Qiuyan Tian, Lei Wu, Mei Li, Jian Huang, Hong Ni, Lixiao Xu et al. · 2025 · Genes & Diseases
  73. Hydrogel-enabled precision therapies for stroke: achieving superior outcomes across the disease continuum
    Xiaoxiao Zhao, Li’ang Zhao, Na Zhang, Jiawei Wang, Yue Zhang, Sijia Cheng, Yang Ji, Huazhe Yang, Wenjing Yu · 2026 · European Polymer Journal
  74. Etude des mécanismes sous-tendant la récupération fonctionnelle post-AVC associée à la transplantation différée de cellules hADSC exprimant le neuropeptide PACAP.
    Roxane Gruel · 2019 · theses.fr (ABES)
  75. Caractérisation de l'activité oscillatoire spontanée du cortex peri-lesionnel lors de la récupération fonctionnelle post-ischémique
    Michael Alasoadura · 2022 · theses.fr (ABES)
  76. Normal Aging Limits Cortical Network Reorganization and Behavioral Recovery after Experimental Stroke
    Asher J. Albertson, Ryan M. Bowen, Kyrillos Ayoub, Rose A León-Alvarado, Brendon Wang, Roman Pati, Adam Q. Bauer, Jin‐Moo Lee · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  77. A role for nucleolin in functional improvement in stroke
    Samuel P. Bridges, Mary Hovanesyan, Srbui Azarapetian, Ofri Abraham, Ida Rishal, Mike Fainzilber, Stanley Thomas Carmichael · 2026 · iScience
  78. Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice
    Tokiharu Sato, Yuka Nakamura, Kana Hoshina, Ken‐ichi Inoue, Masahiko Takada, Masato Yano, Hitoshi Matsuzawa, Masaki Ueno · 2026 · Nature Communications
  79. Shared transcriptomic signatures in perilesional and contralesional cortex after ischemic stroke
    Dene Betz, Victoria A. Alers, Matthew R. Kenwood, Kielen R. Zuurbier, Rebeca Coimbra, Priscilla Rhoton, Erik J. Plautz, Peter M. Douglas, Denise M. O. Ramirez, Ann Marie Stowe et al. · 2026 · Journal of Neuroinflammation
  80. Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway
    Zhihui Li, Qian Wang, Kaixuan Ma, Mengna Yu, Yanyan Wang, Zhou Ge, Peng Lin, Hui Wang, Lexun Lin, Yang Chen et al. · 2026 · Journal of Integrative Neuroscience
  81. From Neuroinflammation to Precision Stroke Recovery: A Phase-Specific Immune–Metabolic Framework
    Pratchaya Kaewkaen · 2026 · Frontiers in Bioscience-Landmark