The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Abstract
The generation of neurons from stem cells involves the activity of proneural basic helix-loop-helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem cells to neuronal differentiation is not known. Here we report that expression of the transcription factors Sox1, Sox2 and Sox3 (Sox1-3) is a critical determinant of neurogenesis. Using chick in ovo electroporation, we found that Sox1-3 transcription factors keep neural cells undifferentiated by counteracting the activity of proneural proteins. Conversely, the capacity of proneural bHLH proteins to direct neuronal differentiation critically depends on their ability to suppress Sox1-3 expression in CNS progenitors. These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins.
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“Members of SoxB1 and SoxB2 subgroups are especially important during neurogenesis [68,69].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [68]
Citations
Cites
Multipotent cell lineages in early mouse development depend on SOX2 functionPreprint
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NeuN, a neuronal specific nuclear protein in vertebratesxs
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Proneural genes and the specification of neural cell types
Bertrand, N., Castro, D. S., & Guillemot, F. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn874 · Cited by 1,572
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
PCNA: structure, functions and interactions
Kelman, Z. (1997) · Oncogene · doi:10.1038/sj.onc.1200886 · Cited by 929
From head to toes: the multiple facets of Sox proteins
Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890
Identification of neurogenin, a vertebrate neuronal determination gene.
Ma, Q.-F., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 874
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Pairing SOX off: with partners in the regulation of embryonic development
Kamachi, Y., Uchikawa, M., & Kondoh, H. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01955-1 · Cited by 641
Cited by
Sorted by citations
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate
Sarkar, A., & Hochedlinger, K. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.007 · Cited by 915
Suh, H., Consiglio, A., Ray, J., Sawai, T., D’Amour, K. A., & Gage, F. H. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.09.002 · Cited by 851
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
Arnold, K., Sarkar, A., Yram, M. A., Polo, J. M., Bronson, R. T., Sengupta, S., Seandel, M., Geijsen, N., & Hochedlinger, K. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.09.001 · Cited by 770
Developmental genetics of vertebrate glial–cell specification
Rowitch, D. H., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature09611 · Cited by 774
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
Ferri, L., Cavallaro, M., Braida, D., Cristofano, A. D., Canta, A., Vezzani, A., Ottolenghi, S., Pandolfi, P. P., Sala, M., Debiasi, S., et al. (2004) · Development · doi:10.1242/dev.01204 · Cited by 688
Metadata
- Authors
- Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J.
- Affiliations
- Karolinska Institutet (SE)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Muhr, Jonas
- Venue
- Nature Neuroscience
- Published
- 2003-09-28
- Volume
- 6
- Issue
- 11
- Pages
- 1162-1168
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2031683488
- Cited by
- 825
- References
- 51
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 27 · 2023: 28 · 2022: 27 · 2021: 23 · 2020: 35 · 2019: 27 · 2018: 39 · 2017: 23 · 2016: 32 · 2015: 51 · 2014: 45 · 2013: 55 · 2012: 54
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neurogenesis, SOX1, SOX2, SOX3, neuronal differentiation, neural stem cells, transcriptional repression, chick embryo, in ovo electroporation
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Differentiation, Chick Embryo, DNA-Binding Proteins, Drosophila, Embryonic Induction, Eye Proteins, High Mobility Group Proteins, Membrane Glycoproteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Nuclear Proteins, Phosphopyruvate Hydratase, Spinal Cord, Stem Cells, Time Factors, Transcription Factors, Tubulin, Vertebrates, Proto-Oncogene Proteins c-myc, Neurofilament Proteins, Helix-Loop-Helix Motifs, Electroporation, Homeodomain Proteins, Gene Expression Regulation, Developmental, HMGB Proteins, Drosophila Proteins, Avian Proteins, Mice, PAX7 Transcription Factor, Basic Helix-Loop-Helix Proteins, SOXB1 Transcription Factors, LIM-Homeodomain Proteins
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