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Distant influences of amygdala lesion on visual cortical activation during emotional face processing
Open accessAbstract
Emotional visual stimuli evoke enhanced responses in the visual cortex. To test whether this reflects modulatory influences from the amygdala on sensory processing, we used event-related functional magnetic resonance imaging (fMRI) in human patients with medial temporal lobe sclerosis. Twenty-six patients with lesions in the amygdala, the hippocampus or both, plus 13 matched healthy controls, were shown pictures of fearful or neutral faces in task-releant or task-irrelevant positions on the display. All subjects showed increased fusiform cortex activation when the faces were in task-relevant positions. Both healthy individuals and those with hippocampal damage showed increased activation in the fusiform and occipital cortex when they were shown fearful faces, but this was not the case for individuals with damage to the amygdala, even though visual areas were structurally intact. The distant influence of the amygdala was also evidenced by the parametric relationship between amygdala damage and the level of emotional activation in the fusiform cortex. Our data show that combining the fMRI and lesion approaches can help reveal the source of functional modulatory influences between distant but interconnected brain regions.
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“These findings suggest that the amygdala plays a critical role in face emotion processing, perhaps via control of response in posterior perceptual regions (Vuilleumier et al., 2004).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Vuilleumier et al., 2004
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Metadata
- Authors
- Vuilleumier, P., Richardson, M. P., Armony, J. L., Driver, J., & Dolan, R. J.
- Affiliations
- University of Geneva (CH)
- National Hospital for Neurology and Neurosurgery (GB)
- Douglas Mental Health University Institute (CA)
- University College London (GB)
- Corresponding author
- Vuilleumier, Patrik
- Venue
- Nature Neuroscience
- Published
- 2004-10-24
- Volume
- 7
- Issue
- 11
- Pages
- 1271-1278
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2109661582
- Cited by
- 955
- References
- 53
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 32 · 2021: 35 · 2020: 34 · 2019: 43 · 2018: 35 · 2017: 37 · 2016: 65 · 2015: 46 · 2014: 55 · 2013: 65 · 2012: 56
- FWCI
- 22.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Funders
- National Science Foundation
- Wellcome Trust
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, amygdala lesions, emotional face processing, fusiform cortex, visual cortex, hippocampal lesions, fearful faces
- MeSH terms
- Adult, Amygdala, Analysis of Variance, Attention, Brain Diseases, Brain Mapping, Emotions, Epilepsy, Temporal Lobe, Facial Expression, Female, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Mental Processes, Middle Aged, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Visual Cortex, Case-Control Studies
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