Cited by 1,575Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

Mechanisms of emotional arousal and lasting declarative memory.

Cahill, Larry, McGaugh, James L.·1998·Trends in Neurosciences

Abstract

Neuroscience is witnessing growing interest in understanding brain mechanisms of memory formation for emotionally arousing events, a development closely related to renewed interest in the concept of memory consolidation. Extensive research in animals implicates stress hormones and the amygdaloid complex as key, interacting modulators of memory consolidation for emotional events. Considerable evidence suggests that the amygdala is not a site of long-term explicit or declarative memory storage, but serves to influence memory-storage processes in other brain regions, such as the hippocampus, striatum and neocortex. Human-subject studies confirm the prediction of animal work that the amygdala is involved with the formation of enhanced declarative memory for emotionally arousing events.

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Crossref · 10.1016/s0166-2236(97)01214-9

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  • Emotionally salient events engage the arousal system and may facilitate encoding and drive enhanced consolidation of the corresponding memory traces.

    “For example, emotionally salient events, which engage the arousal system, may facilitate the encoding and drive enhanced consolidation of the corresponding memory traces (e.g., refs. 30,31).”
  • This effect reflects the modulatory role of the amygdala on hippocampus based declarative and episodic memory.

    “This effect reflects the modulatory role of the amygdala on hippocampus based declarative and episodic memory [51].”

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Authors
Cahill, L., & McGaugh, J. L.
Affiliations
University of California, Irvine (US)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1998-07
Volume
21
Issue
7
Pages
294-299
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2139502395
Cited by
1,575
References
81
Citations by year
2026: 23 · 2025: 34 · 2024: 46 · 2023: 31 · 2022: 35 · 2021: 35 · 2020: 60 · 2019: 36 · 2018: 48 · 2017: 38 · 2016: 49 · 2015: 65 · 2014: 64 · 2013: 70 · 2012: 72
FWCI
6.82
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
emotional arousal, declarative memory, memory consolidation, amygdala, stress hormones, hippocampus, emotional memory, striatum, neocortex
MeSH terms
Amygdala, Animals, Arousal, Corticosterone, Epinephrine, Humans, Learning, Memory, Memory, Short-Term, Mental Processes, Models, Neurological, Retention, Psychology, Stress, Physiological

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