Cited by 550Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Molecular and anatomical determinants of central leptin resistance

Münzberg, Heike, Myers, Martin G·2005·Nature Neuroscience

DOI 10.1038/nn1454

Open this paper in CoChat — free account

Abstract

The increasing incidence of obesity in developed nations is an ever-growing challenge to health care, promoting diabetes and other diseases. The hormone leptin, which is derived from adipose tissue, regulates feeding and energy expenditure. Most forms of obesity are associated with diminished responsiveness to the appetite-suppressing effects of leptin. Here we review the mechanisms by which leptin activates intracellular signals, the roles of these signals in leptin action in vivo, and mechanisms that may attenuate leptin signaling, limiting its action in obese individuals. We highlight data regarding the expression of SOCS3 (a potential mediator of leptin resistance) in the arcuate nucleus of the hypothalamus.

Integrity signals

Registry

Crossref · 10.1038/nn1454

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374
The Leptin Receptor
Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289
Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · cited 1×
“, and it ameliorates the hyperphagia and endocrine abnormalities associated with very low body-fat content caused by a number of lipodystrophic and eating disorder”
Background
From Lesions to Leptin
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038

Flagged first, then by citations

Show all 66 references

Sorted by citations

Items 401–500 of 548

Regulation of the Energy Balance
Vieira, E. E. S., Lima, N. D. S., de Matos‐Neto, E. M., & Torres‐Leal, F. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816093-0.00018-5 · Cited by 3
Unraveling molecular mechanisms involved in the development of leptin resistance using the pig as a model
Mármol‐Sánchez, E., Artman, J. S., Fredholm, M., & Cirera, S. (2020) · Animal Genetics · doi:10.1111/age.13028 · Cited by 3
Pericytic porters: helping leptin step in
Torres, D. J., & Pitts, M. W. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.08.001 · Cited by 3
Linking Obesity, Metabolism, and Cancer
Vučenik, I., Jones, L. P., & McLenithan, J. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_50 · Cited by 3
Pathophysiology of Obesity
Shukla, A. P., Moreira, M., & Rubino, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-70004-0_2 · Cited by 3
Food Perception in Adults: Neuroimaging Findings
Key, A. P. F., Charboneau, E. J., & Cowan, R. L. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_34 · Cited by 4
Pathophysiology of Obesity
Shukla, A. P., Moreira, M., & Rubino, F. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1710-2_2 · Cited by 3
Suppressor of cytokine signaling 3 in the human hypothalamus
Alkemade, A., Unmehopa, U. A., Hessel, E. V. S., Swaab, D. F., Kalsbeek, A., & Fliers, E. (2012) · Peptides · doi:10.1016/j.peptides.2012.03.004 · Cited by 3
Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity
Valentino, M. A., Colón‐González, F., Lin, J. E., & Waldman, S. A. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.33 · Cited by 3
The Role of Adipose Tissue Vasculature in Energy Balance
Kim, H.-J., Choi, S.-H., Chun, B., & Kim, D.-H. (2011) · Journal of Korean Society of Pediatric Endocrinology · doi:10.6065/jkspe.2011.16.3.139 · Cited by 3
Does selective leptin resistance cause obesity-related hypertension?
Correia, M., & Haynes, W. G. (2008) · Cited by 3
Linking Obesity, Metabolism and Cancer
Vučenik, I., Jones, L. P., & McLenithan, J. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_50-1 · Cited by 3
Adipokines and Inflammation
Fantuzzi, G., & Gove, M. E. (2009) · Oxidative stress and disease · doi:10.1201/9781420091311.ch5 · Cited by 4
Adenovirus 36 y su potencial contribución en el desarrollo de obesidad
Villavicencio, F., & Valladares, M. (2017) · Revista médica de Chile · doi:10.4067/s0034-98872017000801054 · Cited by 3
Obesity, Cancer and the Immune System: Cross Talks and Complex Interplay
Kamel, H. F. M., Al-Amodi, H. S. A. B., & Abdelsattar, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_105-1 · Cited by 3
Factors in the regulation of cycles of binge eating behavior
Knapp, A. (2015) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · Cited by 3
La leptine : du gène aux effets sur l’équilibre énergétique
Basdevant, A., & Ciangura, C. (2007) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)33027-4 · Cited by 3
Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity
Cheng, Z., Lu, Y.-F., He, Y., Wei, W., Xie, Y.-X., Lv, T.-S., Wei, Y., Lou, Y., Yu, J.-Y., & Zhou, X.-Q. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i12.113660 · Cited by 2
Obesity: Nature or Nurture?
Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3_1 · Cited by 2
Neurochemical Aspects of Alzheimer Disease
Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_1 · Cited by 2
Enerji Metabolizması, Obezite ve Hormonlar
Ulutaş, D. S. S., Acar, N. E., & Yıldırım, İ. (2020) · Türkiye Spor Bilimleri Dergisi · doi:10.32706/tusbid.719671 · Cited by 3
Multidimensional analysis of the association between metabolic abnormality combinations and depressive symptoms in overweight and obese populations: Cross-sectional evidence from two multinational cohorts
Chen, Y.-X., Lin, Y., Yang, Q.-W., Ye, B., Gao, Z.-H., Hu, D.-S., Liu, J.-T., Yang, D.-C., Dong, Y., Cui, G.-W., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119794 · Cited by 3
Environmental Factors’ Interference in Endocrine Aspects of Male Reproduction
Pivonello, C., de Angelis, C., Garifalos, F., Pivonello, R., & Colao, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-35213-4_3 · Cited by 2
Zespół metaboliczny - aktualny stan wiedzy o przyczynach i patomechanizmach
Pawłowska, J., Witkowski, J. M., & Bryl, E. (2009) · Via Medica Journals · Cited by 2
Circulating Concentrations of Leptin Hormone, Soluble Leptin Receptor and Free Leptin Index in Obese Egyptian Women Before and after Diet Therapy
Shebini, S. M. E., Ghattas, L. A., Hamed, I. M., Moaty, M. I. A., Tapozad, S. T., & Hanna, L. M. (2009) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2009.219.226 · Cited by 2
The potential biological mechanisms of obesity effects on depression: A systematic review of the literature and knowledge mining
Gong, Y., Wang, D., Zhang, X., Qu, Z., Liu, P., & Zou, H. (2013) · Health · doi:10.4236/health.2013.511244 · Cited by 2
Adipocyte Dysfunction, Inflammation, and Insulin Resistance in Obesity
Jahansouz, C. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3220-7_5 · Cited by 2
The therapeutic potential of melatonin against hepatotoxicity caused by obesity and NSAIDs: A comprehensive review
Nath, A., Ghosh, S., Dey, T., Chattopadhyay, A., & Bandyopadhyay, D. (2023) · Melatonin Research · doi:10.32794/mr112500162 · Cited by 1
Linking Obesity, Metabolism, and Cancer
Vučenik, I., Jones, L. P., & McLenithan, J. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_50 · Cited by 3
Diabetes in an Undergraduate Class
Watve, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4409-1_3 · Cited by 2
Fat: Beyond Energy Storage
Watve, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4409-1_11 · Cited by 2
The Link Between Obesity and Depression: Exploring Shared Mechanisms
Woo, Y. S., & Bahk, W. (2017) · Springer eBooks · doi:10.1007/978-981-10-6577-4_15 · Cited by 2
Characterization of Feline Adiponectin and its Association with Metabolic Indices in Lean and Obese Cats
Lusby, A. L. (2009) · Cited by 2
The emerging clinical significance of leptin in humans with absolute or relative leptin deficiency
Moschos, S. J., & Mantzoros, C. S. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.med.0000177421.80858.74 · Cited by 2
Bioengineering Obesity: The Skinny on Leptin Delivery
Hickey, M. S. (2005) · Endocrinology · doi:10.1210/en.2005-0835 · Cited by 2
Leptin
Morgan, R. C., & Considine, R. V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.03843-5 · Cited by 2
Leptin Signaling in the Cardiovascular System
Karmazyn, M., Purdham, D. M., Rajapurohitam, V., & Zeidan, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-09552-3_20 · Cited by 2
Role of Adipokines in Development of Metabolic Syndrome
Gupta, V. (2020) · Annals of the National Academy of Medical Sciences (India) · doi:10.1055/s-0040-1712830 · Cited by 1
Phenethyl isothiocyanate ameliorates high-fat diet-induced obesity by antagonizing hypothalamic leptin resistance
Xu, J., Ma, C., Zhang, L., Gao, H., Huang, Q., Deng, Q., Xiang, X., Li, W., & Huang, F. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158234 · Cited by 1
Obesity and Depression
Ho, D., Won, H. Y., Kim, Y., & Lim, W. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_12 · Cited by 1
New Insight Into Male Infertility: Deviation From Basic Tenets of Life
Nasr‐Esfahani, M. H., Naderi, N., Tavalaee, M., & Razi, M. (2026) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/4433444 · Cited by 1
Nutrient Intake, the Concentrations of Leptin, Adiponectin, Cotisol & Insulin by the Body Fat Content of Women
Lee, S. Y., & Bae, H. S. (2012) · 대한지역사회영양학회지 · doi:10.5720/kjcn.2012.17.6.714 · Cited by 1
COMPARAÇÃO ENTRE O ESTADO NUTRICIONAL DE MULHERES IDOSAS E MULHERES JOVENS: RELAÇÃO COM A LEPTINA E O IGF-I
Miyamoto, M. V., de Melo, C. M., & Ribeiro, S. M. L. (2008) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v41i1p58-66 · Cited by 1
Les peptides modulateurs du comportement alimentaire : espoirs et limites pour le traitement de l'obésité
Beck, B. (2006) · Journal de la Société de Biologie · doi:10.1051/jbio:2006002 · Cited by 1
Adipokines in Health and Disease
Ahima, R. S., & Goncalves, M. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_4 · Cited by 1
Postabsorptive Endocrine Factors Controlling Food Intake and Regulation of Body Adiposity
Covașă, M. (2008) · CRC Press eBooks · doi:10.1201/9781420047844.ch11 · Cited by 1
Network Analysis of Obesity Expression Data
Kumar, A., & Gupta, K. (2017) · InTech eBooks · doi:10.5772/65292
[Novel therapeutic approach based on recent understanding of the development of metabolic syndrome].
Hosoi, T. (2011) · Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · doi:10.1248/yakushi.131.1557 · Cited by 1
POSITIONAL CLONING OF ADIPOSITY GENES IN ETHNIC MINORITIES OF THE INSULIN RESISTANCE ATHEROSCLEROSIS FAMILY STUDY
Bowden, D. W., Wing, M. R., Hicks, A. A., Allred, N., Talbert, J., Knauss, S., & Idol, B. (2009) · Cited by 1
Linking Obesity, Metabolism, and Cancer
Vučenik, I., Jones, L. P., & McLenithan, J. C. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_50-2 · Cited by 2
Depression and Cardiovascular Disease in Women: Behavioral and Biological Mechanisms Involved in this Association
Chirinos, D. A., & Schneiderman, N. (2014) · Springer eBooks · doi:10.1007/978-3-319-09241-6_5 · Cited by 1
Leptin, the Autonomic Nervous System, and Hypertension
da Silva, A. A., do Carmo, J. M., Wang, Z., & Hall, J. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_14 · Cited by 1
Combination of chronic stress with fructose diet increases AMP-activated protein kinase phosphorylation and affects agouti-related protein and proopiomelanocortin expression in the hypothalamus of male Wistar rats
Shirif, A. Z., Kovačević, S., Bursać, B. N., Lakic, I. V., Veličković, N. A., Jevdjovic, T. V., & Djordjevic, A. D. (2022) · Acta Biochimica Polonica · doi:10.18388/abp.2020_6075 · Cited by 1
Role of adipokines in the pathophysiology of coronary artery disease
Kumari, R., Kumar, S., Vyavahare, S. S., Srivastava, R., & Srivastava, S. P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99521-4.00021-0 · Cited by 1
Environmental Inputs, Intake of Nutrients, and Endogenous Molecules Contributing to the Regulation of Energy Homeostasis
Kelesidis, T., Kelesidis, I., & Mantzoros, C. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-453-1_3 · Cited by 1
Sympathetic vascular tone in human obesity
Correia, M. (2007) · doi:10.17077/etd.v54kf0if · Cited by 1
Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome
Gandhi, H., & Balaraman, R. (2013) · doi:10.1002/9781118395318.ch18 · Cited by 1
Understanding and Managing Obesity
Corsica, J. A., & Perri, M. G. (2012) · Handbook of Psychology, Second Edition · doi:10.1002/9781118133880.hop209006 · Cited by 1
DIETARY INTAKE AND SELF-REPORTING IN RELATION TO EATING BEHAVIOUR IN OBESE AND TYPE 2 DIABETES PATIENTS
Broom, J. I., Speakman, J. R., & Johnstone, A. M. (2006) · Cited by 1
Role of leptin in the induction of obesity-related inflammation and infection susceptibility
Dib, L. H. (2011) · K-State Research Exchange (Kansas State University) · Cited by 1
Eventos adversos associados aos diferentes tipos de corrente elétrica empregados na papilotomia endoscópica: revisão sistemática e metanálise de ensaios clínicos randomizados
Teixeira, T. A. C. C. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2021.tde-14092021-143839 · Cited by 1
Leptin Signaling In the Brain
Reizes, O., Benoit, S. C., & Clegg, D. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-139-4_2
Adipokines, Inflammation, and Atherosclerosis
Stulnig, T. M., & Zeyda, M. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0338-8_14
Efeito do Fornecimento Crônico de Leptina e da Nutrição na Maturação Sexual de Novilhas Zebuínas (Bos taurus indicus)
de Carvalho, M. V. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.10.2009.tde-23032011-162453
Aminopeptidase neutra, dipeptidil peptidase IV, CD13, CD26 e Fos no hipotálamo e hipocampo de ratos com obesidade induzida por glutamato monossódico e privados de alimento
Alponti, R. F. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.47.2008.tde-20032009-122119
Molecular mechanisms of antidiabetic effects of estrogen
Bryzgalova, G. (2008) · Figshare
The impact of exercise, adiposity and persistent viral infection on blood T-Cell phenotype and function
Spielmann, G. (2026) · Edinburgh Napier Research Repository (Edinburgh Napier University) · doi:10.17869/enu.192070
Leptin and insulin as adiposity signals
Niswender, K. D. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541643.005
Cancer du sein et micro-environnement tumoral : rôle de la protéase cathepsine D adipocytaire et de son récepteur LRP1
Masson, O. (2009) · theses.fr (ABES)
A obesidade diminui a resposta de artérias mesentéricas de resistência a agonistas canabinóides.
Lobato, N. D. S. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2010.tde-14012011-162359
Produção de leptina recombinante bovina em leveduras Pichia pastoris e avaliação da atividade biológica
de Carvalho, M. V. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2014.tde-30072014-134946
Alteraciones del proceso adipogénico in vitro en modelos experimentales de síndrome metabólico
Zubiría, M. G. (2014) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/35146
Roux-en-Y gastric bypass versus sleeve gastrectomy: a meta-analysis
Nietz, S. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Use of Visceral Adipocyte Biomarkers in Endometrial Cancer
Han, L. Y., & Lin, Y. G. (2015) · Biomarkers in disease · doi:10.1007/978-94-007-7681-4_28
Redução hipotalamica da PTP-1B melhora a sensibilidade a insulina e leptina em ratos normais e obesos
Picardi, P. K. (2007) · doi:10.47749/t/unicamp.2007.415733
Metabolic Syndrome as a Risk Factor for Stroke
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_7
Caracterização da transmissão do sinal da insulina e da leptina em hipotalamo de roedores durante a anorexia induzida pelo cancer
Ropelle, E. R. (2010) · doi:10.47749/t/unicamp.2010.477520
The obese brain: neuroendocrine modulations in the reward system
van den Munkhof, H. E. (2013) · Utrecht University Repository (Utrecht University)
Hyperleptinemia, Leptin Resistance, and Cognition in Hemodialysis Patients
Bossola, M., & Tazza, L. (2011) · Renal Failure · doi:10.3109/0886022x.2011.618975
Relationship of centrally-located body fat to appetitive hormones in healthy postmenopausal women
Ritland, L. (2008) · doi:10.31274/rtd-180813-16419
Obesità e ipertensione arteriosa
Verdecchia, P., & Trimarco, B. (2008) · Giornale italiano di cardiologia · doi:10.1714/669.7813
Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
Rune, A. (2009) · Figshare
Expressão de genes hipotalâmicos em novilhas Nelore precoces e não precoces
Vaiciunas, A. (2007) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.10.2007.tde-13082007-110544
FARELERDE LEPTİNİN LENFOSİT ALT TİPLERİ ÜZERİNE İN VİVO ETKİLERİ
Üner, A. G. (2009)
IMPACT OF OBESITY ON THE SUSCEPTIBILITY OF THE MYOCARDIUM TO HYPERTENSIVE AND ADRENERGIC-INDUCED APOPTOSIS
Vengethasamy, L. (2010) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
E A Review: "Leptin Structure and Mechanism Actions"
Al-Jumaily, E. F. A., & Zgaer, S. H. (2014)
Obesity - surgical treatment and molecular mechanisms
Anveden, Å. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Fatores moleculares envolvidos nas alterações metabólicas durante a gestação: papel do SOCS3.
Zampieri, T. T. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-07122015-181252
Effect of Voluntary Exercise and Diet on the Unfolded Protein Response in the Brain of Mice
Kim, Y. H. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/0638-1259
Does chronic leptin treatment decrease glucagon responsiveness in STZ-induced type 1 diabetic rats?
Rowland, K. E. (2013)
Determinantes del aumento de peso producido por los antipsicóticos: un estudio de cohortes
Velasco, V. (2016) · doi:10.35376/10324/16294
Obesity alters the immune response to influenza virus infection: a mechanism for immune modulation
Smith, A. G. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/8g6s-9d79
The influence of diet-induced obesity on the generation, function and maintenance of influenza-specific memory CD8+ T cells
Karlsson, E. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/z7a5-ph53
The immunological consequences of obesity on primary and secondary immune defenses to the 2009 pandemic H1N1 influenza virus
Milner, J. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/c8p3-s268
UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DA SAÚDE:
Cardiovasculares, C. E. C., & Medicina, F. D. (2009)
Food-intake Regulating Peptide and Its Functional Relationship with the Cerebral Network - Including Its Application as an Antiobesity Agent
Ueno, H., & Nakazato, M. (2007) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.96.1491
Obesity and ER Stress
Koo, S. (2011) · The Korean Journal of Obesity · doi:10.7570/kjo.2011.20.2.45
Intracellular signalling pathways activated by leptin
õnica, C. ́. (2006)
The isolation of novel leptin variants using phage display
Tomini, K. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Obesity and the hypOthalamus
Roberto, P., Mosca, F., & Silveira, P. P. (2013)

Authors: Münzberg, H., & Myers, M. G.
Affiliations: University of Michigan (US)
Corresponding author: Myers, Martin G
ORCID: Münzberg, Heike
Myers, Martin G
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-04-26
Volume: 8
Issue: 5
Pages: 566-570
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1454
OpenAlex: W2042893069
Semantic Scholar: 71b5dabe299be6d5e8f778fa2686a524e8e2be92
Cited by: 550
References: 66
Citations by year: 2026: 8 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 16 · 2019: 18 · 2018: 10 · 2017: 18 · 2016: 27 · 2015: 36 · 2014: 40 · 2013: 29 · 2012: 30
FWCI: 4.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: leptin resistance, leptin signaling, obesity, SOCS3, arcuate nucleus, hypothalamus, appetite regulation, energy expenditure, intracellular signaling
MeSH terms: Suppressor of Cytokine Signaling 3 Protein, Adipose Tissue, Animals, Appetite Regulation, Energy Metabolism, Humans, Hypothalamus, Obesity, Receptors, Cell Surface, Repressor Proteins, Transcription Factors, Signal Transduction, Leptin, Suppressor of Cytokine Signaling Proteins, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular and anatomical determinants of central leptin resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks