Mechanisms of leptin action and leptin resistance.

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works

SH2 domains recognize specific phosphopeptide sequences

Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,675 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346 · see citing works

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., & Lechler, R. I. (1998) · Nature · doi:10.1038/29795 · Cited by 2,150 · see citing works

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

Koch, C. A., Anderson, D. H., Moran, M. F., Ellis, C. A., & Pawson, T. J. (1991) · Science · doi:10.1126/science.1708916 · Cited by 1,868 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Gp130 and the interleukin-6 family of cytokines.

Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,603 · see citing works

The Neuroscience of Natural Rewards: Relevance to Addictive Drugs

Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

From Lesions to Leptin

Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160 · see citing works

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086 · see citing works

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · see citing works

Jaks and Stats in signaling by the cytokine receptor superfamily.

Ihle, J., & Kerr, I. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89000-9 · Cited by 953 · see citing works

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works

Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding

Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Chen, A. S., Marsh, D. J., Trumbauer, M. E., Frazier, E. G., Guan, X.-M., Yu, H., Rosenblum, C. I., Vongs, A., Feng, Y., Cao, L., et al. (2000) · Nature Genetics · doi:10.1038/79254 · Cited by 896 · see citing works

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works

PTP1B Regulates Leptin Signal Transduction In Vivo

Zabolotny, J. M., Bence, K. K., Stricker‐Krongrad, A., Haj, F. G., Wang, Y., Minokoshi, Y., Kim, Y., Elmquist, J. K., Tartaglia, L. A., Kahn, B. B., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00148-x · Cited by 816 · see citing works

Activation of Downstream Signals by the Long Form of the Leptin Receptor

Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797 · see citing works

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

Erickson, J. C., Hollopeter, G., & Palmiter, R. D. (1996) · Science · doi:10.1126/science.274.5293.1704 · Cited by 794 · see citing works

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737 · see citing works

Cytokine signaling through nonreceptor protein tyrosine kinases.

Taniguchi, T. (1995) · Science · doi:10.1126/science.7716517 · Cited by 712 · see citing works

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

Butler, A. A., Kesteson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., DeKoning, J., Baetscher, M., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7791 · Cited by 703 · see citing works

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651 · see citing works

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works

Neuronal PTP1B regulates body weight, adiposity and leptin action

Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633 · see citing works

Key enzyme in leptin-induced anorexia

Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585 · see citing works

Diet-Induced Obesity Causes Severe but Reversible Leptin Resistance in Arcuate Melanocortin Neurons

Enriori, P. J., Evans, A. E., Sinnayah, P., Jobst, E. E., Tonelli-Lemos, L., Billes, S. K., Glavas, M. M., Grayson, B. E., Perello, M., Nillni, E. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.004 · Cited by 552 · see citing works

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

Marsh, D. J., Hollopeter, G., Huszar, D., Laufer, R., Yagaloff, K. A., Fisher, S. L., Burn, P., & Palmiter, R. D. (1999) · Nature Genetics · doi:10.1038/5070 · Cited by 545 · see citing works

Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

Cheng, A., Uetani, N., Simoncic, P. D., Chaubey, V. P., Lee-Loy, A., McGlade, C. J., Kennedy, B. P., & Tremblay, M. L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00149-1 · Cited by 539 · see citing works

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007577200 · Cited by 537 · see citing works

Unraveling the central nervous system pathways underlying responses to leptin

Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience · doi:10.1038/2164 · Cited by 520 · see citing works

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works

Monogenic Obesity in Humans

Farooqi, I. S., & O’Rahilly, S. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.56.062904.144924 · Cited by 439 · see citing works

Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem

Elmquist, J. K., Ahima, R. S., Maratos–Flier, E., Flier, J. S., & Saper, C. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.5033 · Cited by 438 · see citing works

Modulation of Brain Reward Circuitry by Leptin

Fulton, S. E., Woodside, B. C., & Shizgal, P. (2000) · Science · doi:10.1126/science.287.5450.125 · Cited by 421 · see citing works

PI3K integrates the action of insulin and leptin on hypothalamic neurons

Xu, A. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524301 · Cited by 420 · see citing works

Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits <i>Janus</i> tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain

Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J. A., & Yoshimura, A. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00263.x · Cited by 398 · see citing works

Neuropeptide Y Stimulates Feeding but Inhibits Sexual Behavior in Rats*

Clark, J. T., Kalra, P. S., & Kalra, S. P. (1985) · Endocrinology · doi:10.1210/endo-117-6-2435 · Cited by 392 · see citing works

Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells

Kieffer, T. J., Heller, R. S., Leech, C. A., Holz, G. G., & Habener, J. F. (1997) · Diabetes · doi:10.2337/diab.46.6.1087 · Cited by 392 · see citing works

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

Ste. Marie, L., Miura, G. I., Marsh, D. J., Yagaloff, K., & Palmiter, R. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220409497 · Cited by 366 · see citing works

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007439200 · Cited by 364 · see citing works

Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y 1007 in the Kinase Activation Loop

Feng, J., Witthuhn, B. A., Matsuda, T., Kohlhuber, F., Kerr, I. M., & Ihle, J. N. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2497 · Cited by 358 · see citing works

CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2

Sasaki, A. T., Yasukawa, H., Shouda, T., Kitamura, T., Đikić, I., & Yoshimura, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003456200 · Cited by 341 · see citing works

Cannabinoids, opioids and eating behavior: The molecular face of hedonism?

Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.004 · Cited by 330 · see citing works

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27123 · Cited by 326 · see citing works

Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin

Inui, A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01292-2 · Cited by 318 · see citing works

Diverse Biochemical Properties of Shp2 Mutants

Keilhack, H., David, F. S., McGregor, M. J., Cantley, L. C., & Neel, B. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504699200 · Cited by 299 · see citing works

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

Kulkarni, R. N., Wang, Z. L., Wang, R. M., Hurley, J. D., Smith, D. M., Ghatei, M. A., Withers, D. J., Gardiner, J. V., Bailey, C. J., & Bloom, S. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119818 · Cited by 296 · see citing works

Leptin Receptor (OB-R) Signaling

White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., & Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4065 · Cited by 293 · see citing works

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

Feng, G.-S. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4668 · Cited by 285 · see citing works

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

Zhang, E. E., Chapeau, E. A., Hagihara, K., & Feng, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405041101 · Cited by 263 · see citing works

Leptin receptor action and mechanisms of leptin resistance

Münzberg, H., Björnholm, M., Bates, S. H., & Myers, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4432-1 · Cited by 260 · see citing works

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

Uotani, S., Bjørbæk, C., Tornøe, J., & Flier, J. S. (1999) · Diabetes · doi:10.2337/diabetes.48.2.279 · Cited by 253 · see citing works

The role of leptin receptor signaling in feeding and neuroendocrine function

Bates, S. H., & Myers, M. G. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.10.003 · Cited by 239 · see citing works

Regulation of Jak Kinases by Intracellular Leptin Receptor Sequences

Kloek, C. E., Haq, A. K., Dunn, S. L., Lavery, H. J., Banks, A. S., & Myers, M. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205148200 · Cited by 233 · see citing works

Critical role of STAT3 in leptin's metabolic actions

Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228 · see citing works

Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations

Considine, R. V., Caro, J. F., Considine, E. L., Williams, C. J., & Hyde, T. M. (1996) · Diabetes · doi:10.2337/diab.45.7.992 · Cited by 228 · see citing works

Developmental programming of hypothalamic feeding circuits

Bouret, S., & Simerly, R. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00684.x · Cited by 227 · see citing works

Effect of Leptin on Arterial Thrombosis Following Vascular Injury in Mice

Bodary, P. F. (2002) · JAMA · doi:10.1001/jama.287.13.1706 · Cited by 225 · see citing works

The melanocortin receptors: Lessons from knockout models

Butler, A. A., & Cone, R. D. (2002) · Neuropeptides · doi:10.1054/npep.2002.0890 · Cited by 222 · see citing works

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31160 · Cited by 222 · see citing works

Leptin Receptor Signaling and Action in the Central Nervous System

Leshan, R. L., Björnholm, M., Münzberg, H., & Myers, M. G. (2006) · Obesity · doi:10.1038/oby.2006.310 · Cited by 221 · see citing works

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

Figlewicz, D. P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00602.2002 · Cited by 221 · see citing works

Differential Accessibility of Circulating Leptin to Individual Hypothalamic Sites

Faouzi, M., Leshan, R. L., Björnholm, M., Hennessey, T., Jones, J. C., & Münzberg, H. (2007) · Endocrinology · doi:10.1210/en.2007-0655 · Cited by 205 · see citing works

Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

Baskin, D. G., Schwartz, M. W., Seeley, R. J., Woods, S. C., Porte, D., Breininger, J. F., Jonak, Z., Schaefer, J., Krouse, M., Burghardt, C., et al. (1999) · Journal of Histochemistry &amp; Cytochemistry · doi:10.1177/002215549904700309 · Cited by 200 · see citing works

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

Björnholm, M., Münzberg, H., Leshan, R. L., Villanueva, E. C., Bates, S. H., Louis, G. W., Jones, J. C., Ishida-Takahashi, R., Bjørbaek, C., & Myers, M. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30688 · Cited by 183 · see citing works

Integration of the regulation of reproductive function and energy balance: lactation as a model

Smith, M. S., & Grove, K. L. (2002) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00002-x · Cited by 181 · see citing works

Generation of Soluble Leptin Receptor by Ectodomain Shedding of Membrane-spanning Receptors in Vitro and in Vivo

Ge, H., Huang, L., Pourbahrami, T., & Li, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205825200 · Cited by 181 · see citing works

Chronic food restriction: Enhancing effects on drug reward and striatal cell signaling

Carr, K. D. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.021 · Cited by 180 · see citing works

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C., & Friedman, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9677 · Cited by 177 · see citing works

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, L. R., Farruggella, T. J., Symes, A. J., Karow, M. L., Yancopoulos, G. D., & Stahl, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6061 · Cited by 175 · see citing works

The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis

Covey, S. D., Wideman, R. D., McDonald, C. M., Unniappan, S., Huynh, F. K., Asadi, A., Speck, M., Webber, T. D., Chua, S. C., & Kieffer, T. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.09.005 · Cited by 174 · see citing works

The Long Form of the Leptin Receptor Regulates STAT5 and Ribosomal Protein S6 via Alternate Mechanisms

Gong, Y., Ishida-Takahashi, R., Villanueva, E. C., Fingar, D. C., Münzberg, H., & Myers, M. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702838200 · Cited by 173 · see citing works

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.001 · Cited by 173 · see citing works

Intraventricular Insulin and Leptin Reverse Place Preference Conditioned With High-Fat Diet in Rats.

Figlewicz, D. P., Bennett, J. L., Evans, S. B., Kaiyala, K. J., Sipols, A. J., & Benoit, S. C. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.479 · Cited by 172 · see citing works

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

Maffei, M., Stoffel, M., Barone, M., Moon, B. C., Dammerman, M., Ravussin, É., Bogardus, C., Ludwig, D. S., Flier, J. S., Talley, M., et al. (1996) · Diabetes · doi:10.2337/diab.45.5.679 · Cited by 171 · see citing works

Inactivation of Signal Transducer and Activator of Transcription 3 in Proopiomelanocortin (Pomc) Neurons Causes Decreased Pomc Expression, Mild Obesity, and Defects in Compensatory Refeeding

Xu, A. W., Marie, L. S., Kaelin, C. B., & Barsh, G. S. (2006) · Endocrinology · doi:10.1210/en.2006-1119 · Cited by 165 · see citing works

Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

White, M. F. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-008 · Cited by 163 · see citing works

Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

Devos, R., Guisez, Y., der Heyden, J. V., White, D. W., Kalai, M., Fountoulakis, M., & Plaetinck, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18304 · Cited by 163 · see citing works

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

Morton, G. J., Niswender, K. D., Rhodes, C. J., Myers, M. G., Blevins, J. E., Baskin, D. G., & Schwartz, M. W. (2003) · Endocrinology · doi:10.1210/en.2002-0115 · Cited by 158 · see citing works

Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts

Chua, S. C., Koutras, I. K., Han, L., Liu, S.-M., Kay, J., Young, S. J., Chung, W. K., & Leibel, R. L. (1997) · Genomics · doi:10.1006/geno.1997.4962 · Cited by 156 · see citing works

The many lives of leptin

Banks, W. A. (2004) · Peptides · doi:10.1016/j.peptides.2004.02.014 · Cited by 153 · see citing works

Feedback Inhibition of Leptin Receptor/Jak2 Signaling via Tyr1138 of the Leptin Receptor and Suppressor of Cytokine Signaling 3

Dunn, S. L., Björnholm, M., Bates, S. H., Chen, Z., Seifert, M. M., & Myers, M. G. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0353 · Cited by 151 · see citing works

Modulation of food reward by adiposity signals

Figlewicz, D. P., Naleid, A. M., & Sipols, A. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.10.008 · Cited by 149 · see citing works

Central Nervous System Regulation of Food Intake

Schwartz, M. W. (2006) · Obesity · doi:10.1038/oby.2006.275 · Cited by 146 · see citing works

Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity

Argetsinger, L. S., Kouadio, J.-L. K., Steen, H., Stensballe, A., Jensen, O. N., & Carter‐Su, C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4955-4967.2004 · Cited by 142 · see citing works

LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin

Bates, S. H., Dundon, T. A., Seifert, M., Carlson, M., Maratos-Flier, E., & Myers, M. G. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3067 · Cited by 139 · see citing works

“The role of melanocortins in body weight regulation: opportunities for the treatment of obesity”

MacNeil, D. J., Howard, A. D., Guan, X.-M., Fong, T. M., Nargund, R. P., Bednarek, M. A., Goulet, M. T., Weinberg, D. H., Strack, A. M., Marsh, D. J., et al. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01989-1 · Cited by 137 · see citing works

Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

Couturier, C., & Jockers, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302002200 · Cited by 132 · see citing works

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

Hekerman, P., Zeidler, J., Bamberg‐Lemper, S., Knobelspies, H., Lavens, D., Tavernier, J., Joost, H., & Becker, W. (2004) · The FEBS Journal · doi:10.1111/j.1432-1033.2004.04391.x · Cited by 129 · see citing works

Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling

Feener, E. P., Rosario, F., Dunn, S. L., Stancheva, Z. S., & Myers, M. G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4968-4978.2004 · Cited by 113 · see citing works

Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-Bβ

Kurzer, J. H., Argetsinger, L. S., Zhou, Y.-J., Kouadio, J.-L. K., O’Shea, J. J., & Carter‐Su, C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4557-4570.2004 · Cited by 107 · see citing works

Photoperiodic Regulation of Leptin Sensitivity in the Siberian Hamster, Phodopus sungorus, Is Reflected in Arcuate Nucleus SOCS-3 (Suppressor of Cytokine Signaling) Gene Expression

Tups, A., Ellis, C., Moar, K. M., Logie, T. J., Adam, C. L., Mercer, J. G., & Klingenspor, M. (2003) · Endocrinology · doi:10.1210/en.2003-1382 · Cited by 102 · see citing works

Identification of the Critical Sequence Elements in the Cytoplasmic Domain of Leptin Receptor Isoforms Required for Janus Kinase/Signal Transducer and Activator of Transcription Activation by Receptor Heterodimers

Bahrenberg, G., Behrmann, I., Barthel, A., Hekerman, P., Heinrich, P. C., Joost, H., & Becker, W. B. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.4.0800 · Cited by 102 · see citing works

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

Burcelin, R., Kamohara, S., Li, J., Tannenbaum, G. S., Charron, M. J., & Friedman, J. M. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1264 · Cited by 92 · see citing works

Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2

Funakoshi-Tago, M., Pelletier, S., Matsuda, T., Parganas, E., & Ihle, J. (2006) · EMBO Journal · doi:10.1038/sj.emboj.7601365 · Cited by 89 · see citing works

Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling

Münzberg, H., Jobst, E. E., Bates, S. H., Jones, J. C., Villanueva, E. C., Leshan, R. L., Björnholm, M., Elmquist, J. K., Sleeman, M. W., Cowley, M. A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3168-06.2007 · Cited by 86 · see citing works

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic trh Gene Expression by Leptin

Huo, L., Münzberg, H., Nillni, E. A., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2003-1242 · Cited by 79 · see citing works

Identification, cDNA Cloning, and Targeted Deletion of p70, a Novel, Ubiquitously Expressed SH3 Domain-Containing Protein

Carpino, N., Kobayashi, R., Zang, H., Takahashi, Y., Jou, S.-T., Feng, J., Nakajima, H., & Ihle, J. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7491-7500.2002 · Cited by 75 · see citing works

The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations

Considine, R. V., Considine, E. L., Williams, C. J., Hyde, T. M., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diabetes.45.7.992 · Cited by 72 · see citing works

Leptin Regulates Neointima Formation After Arterial Injury Through Mechanisms Independent of Blood Pressure and the Leptin Receptor/STAT3 Signaling Pathways Involved in Energy Balance

Bodary, P. F., Shen, Y., Öhman, M. K., Bahrou, K. L., Vargas, F. B., Cudney, S. S., Wickenheiser, K. J., Myers, M. G., & Eitzman, D. T. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000252068.89775.ee · Cited by 67 · see citing works

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

Kieffer, T. J., Heller, R. S., Leech, C. A., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.6.1087 · Cited by 65 · see citing works

Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain*

Haan, S., Hemmann, U., Hassiepen, U., Schaper, F., Schneider-Mergener, J., Wollmer, A., Heinrich, P., & Grötzinger, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1342 · Cited by 61 · see citing works

Phosphorylation of Jak2 on Ser 523 InhibitsJak2-Dependent Leptin ReceptorSignaling

Ishida-Takahashi, R., Rosario, F., Gong, Y., Kopp, K., Stancheva, Z. S., Chen, X., Feener, E. P., & Myers, M. G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01589-05 · Cited by 60 · see citing works

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

盛, 裕. (2006) · Medical Entomology and Zoology · Cited by 58 · see citing works

Brain reward circuitry and the regulation of energy balance

Shizgal, P., Fulton, S., & Woodside, B. C. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801906 · Cited by 55 · see citing works

Absence of mutations in the human OB gene in obese/diabetic subjects

Maffei, M., Stoffel, M., Barone, M., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.5.679 · Cited by 54 · see citing works

Determination of the transphosphorylation sites of Jak2 kinase

Matsuda, T., Feng, J., Witthuhn, B. A., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.071 · Cited by 50 · see citing works

Signal Transducer and Activator of Transcription (Stat) Binding Sites But Not Stat3 Are Required for Fasting-Induced Transcription of Agouti-Related Protein Messenger Ribonucleic Acid

Kaelin, C. B., Gong, L., Xu, A. W., Yao, F., Hockman, K., Morton, G. J., Schwartz, M. W., Barsh, G. S., & MacKenzie, R. G. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0107 · Cited by 35 · see citing works

Adiposity signals and brain reward mechanisms

Figlewicz, D. P., & Woods, S. C. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01488-7 · Cited by 29 · see citing works

Altered Expression of SOCS3 in the Hypothalamic Arcuate Nucleus during Seasonal Body Mass Changes in the Field Vole,Microtus agrestis

Król, E., Tups, A., Archer, Z. A., Ross, A., Moar, K. M., Bell, L., Duncan, J. S., Mayer, C., Morgan, P. J., Mercer, J. G., et al. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01507.x · Cited by 27 · see citing works

Potentiation of brain stimulation reward by weight loss: Evidence for functional heterogeneity in brain reward circuitry

Fulton, S. E., Woodside, B. C., & Shizgal, P. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.009 · Cited by 19 · see citing works

Untitled work

Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works

Leptin in Human Physiology and Pathophysiology

Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works

Sex differences in the physiology of eating

Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513 · see citing works

Hypothalamic inflammation in obesity and metabolic disease

Jais, A., & Brüning, J. C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88878 · Cited by 474 · see citing works

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

Lieb, W. (2009) · JAMA · doi:10.1001/jama.2009.1836 · Cited by 428 · see citing works

Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome

Thorp, A. A., & Schlaich, M. P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/341583 · Cited by 425 · see citing works

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

Thaler, J. P., & Schwartz, M. W. (2010) · Endocrinology · doi:10.1210/en.2010-0336 · Cited by 313 · see citing works

Hyperleptinemia Is Required for the Development of Leptin Resistance

Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311 · see citing works

Cytokines and abnormal glucose and lipid metabolism

Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works

Neuroinflammation and neurodegeneration in overnutrition-induced diseases

Cai, D. (2013) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256 · see citing works

Leptin in nonalcoholic fatty liver disease: A narrative review

Polyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2014.10.012 · Cited by 235 · see citing works

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214 · see citing works

Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines

Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210 · see citing works

Leptin Modulates the Intrinsic Excitability of AgRP/NPY Neurons in the Arcuate Nucleus of the Hypothalamus

Baver, S. B., Hope, K., Guyot, S., Bjørbaek, C., Kaczorowski, C., & O'Connell, K. M. S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4861-12.2014 · Cited by 203 · see citing works

Leptin in humans: lessons from translational research

Blüher, S., & Mantzoros, C. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788e · Cited by 203 · see citing works

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

Nogueiras, R., Pérez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., López, M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5977-08.2009 · Cited by 182 · see citing works

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

Reed, A. S., Unger, E. K., Olofsson, L. E., Piper, M. L., Myers, M. G., & Xu, A. W. (2010) · Diabetes · doi:10.2337/db09-1024 · Cited by 176 · see citing works

The physiological control of eating: signals, neurons, and networks

Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168 · see citing works

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

Kleinridders, A., Lauritzen, H. P. M. M., Ussar, S., Christensen, J. H., Mori, M. A., Bross, P., & Kahn, C. R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67615 · Cited by 130 · see citing works

Obesity, leptin, and Alzheimer's disease

Lee, E. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06274.x · Cited by 126 · see citing works

The crosstalk between bone remodeling and energy metabolism: A translational perspective

Karsenty, G., & Khosla, S. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.010 · Cited by 113 · see citing works

Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats

Gali Ramamoorthy, T., Allen, T.-J., Davies, A., Harno, E., Sefton, C., Murgatroyd, C., & White, A. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0094-1 · Cited by 97 · see citing works

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

Nilsson, M. I., Dobson, J. P., Greene, N. P., Wiggs, M. P., Shimkus, K. L., Wudeck, E. V., Davis, A. R., Laureano, M. L., & Fluckey, J. D. (2013) · The FASEB Journal · doi:10.1096/fj.12-224006 · Cited by 87 · see citing works

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A., & Tiganis, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.013 · Cited by 66 · see citing works

A Mathematical Model of Murine Metabolic Regulation by Leptin: Energy Balance and Defense of a Stable Body Weight

Tam, J., Fukumura, D., & Jain, R. K. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.005 · Cited by 52 · see citing works

Molecular Targets for Obesity Therapy in the Brain

Obici, S. (2009) · Endocrinology · doi:10.1210/en.2009-0409 · Cited by 45 · see citing works

Nonalcoholic fatty liver disease and metabolic syndrome in hypopituitary patients

Nyenwe, E. A., Williamson-Baddorf, S., Waters, B., Wan, J. Y., & Solomon, S. S. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181a84bde · Cited by 28 · see citing works

RLIP76 protein knockdown attenuates obesity due to a high-fat diet

Singhal, S. S., Figarola, J., Singhal, J., Reddy, M. A., Liu, X., Berz, D., Natarajan, R., & Awasthi, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.480194 · Cited by 26 · see citing works

Cardiovascular and Sympathetic Effects of Disrupting Tyrosine 985 of the Leptin Receptor

Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L., & Rahmouni, K. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.166538 · Cited by 24 · see citing works

SOCS3 Ablation in Leptin Receptor-Expressing Cells Causes Autonomic and Cardiac Dysfunctions in Middle-Aged Mice despite Improving Energy and Glucose Metabolism

Pedroso, J. A. B., da Silva, I. B., Zampieri, T. T., Totola, L. T., Moreira, T. S., Taniguti, A. P. T., Diniz, G. P., Barreto‐Chaves, M. L. M., & Donato, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126484 · Cited by 13 · see citing works

Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma

Huang, W., Yang, S., Wu, C., Chen, W., Huang, Y., Su, Y., & Chai, C. (2009) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/s1607-551x(09)70569-8 · Cited by 17 · see citing works

Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus

Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., Morgan, P. J., & Trayhurn, P. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05161.x · Cited by 460 · see citing works

Exercise-Induced Activation of STAT3 Signaling Is Increased with Age

Caldow, M. K., Carey, K. A., Ward, A. C., Farnfield, M. M., & Cameron‐Smith, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0643 · Cited by 55 · see citing works

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works