Ghrelin controls hippocampal spine synapse density and memory performance
Diano, Sabrina, Farr, Susan A, Benoit, Stephen C, McNay, Ewan C, da Silva, Ivaldo, Horvath, Balazs, Gaskin, F Spencer, Nonaka, Naoko, Jaeger, Laura B, Banks, William A, Morley, John E, Pinto, Shirly, Sherwin, Robert S, Xu, Lin, Yamada, Kelvin A, Sleeman, Mark W, Tschöp, Matthias H, Horvath, Tamas L·2006·Nature Neuroscience
DOI 10.1038/nn1656
Cited by (826)
Items 501–600 of 826
- A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groupsFeifei Zhao, Joseph E. Darling, Richard A. Gibbs, James L. Hougland · 2015 · Bioorganic & Medicinal Chemistry Letters
- Does hunger sharpen senses? A psychophysics investigation on the effects of appetite in the timing of reinforcement-oriented actionsVicario, Carmelo M., Kuran, Karolina A., Urgesi, Cosimo · 2019 · Psychological Research
- “Sibling” battle or harmony: Crosstalk between nesfatin-1 and ghrelinChen, Xi, Dong, Jing, Jiao, Qian, Du, Xixun, Bi, Mingxia, Jiang, Hong · 2022 · Cellular and Molecular Life Sciences
- Ventral hippocampus neurons encode meal-related memoryLéa Décarie-Spain, Cindy Gu, Logan Tierno Lauer, Keshav S. Subramanian, Samar Nasser Chehimi, Alicia E. Kao, Shangkai Gao, Iris Deng, Alexander G. Bashaw, Molly E. Klug et al. · 2025 · Nature Communications
- Acylation, a Conductor of Ghrelin Function in Brain Health and DiseaseThomas, Alanna S., Sassi, Martina, Angelini, Roberto, Morgan, Alwena H., Davies, Jeffrey S. · 2022 · Frontiers in Physiology
- Metabolic, neuroendocrine and behavioral effects of social defeat in male and female mice using the chronic non-discriminatory social defeat stress modelAndrea Smith, Lindsay Hyland, Hiyam Al-Ansari, Bethany Watts, Zachary A. Silver, Longfei Wang, Miski Dahir, Aleyna Akgun, Andre Telfer, Alfonso B. Abizaid · 2023 · Hormones and Behavior
- SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task.S. Jacoby, P. Currie · 2011 · Neuroscience Letters
- Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic ratsYuxing Zhao, Zhaoxing Shen, Dongling Zhang · 2017 · Metabolic Brain Disease
- Ghrelin Stimulates Hepatocyte Proliferation via Regulating Cell Cycle Through GSK3β/Β-Catenin Signaling PathwayQin Wang, Ming Zheng, Yue Yin · 2018 · Cellular Physiology and Biochemistry
- Effects of adolescent experience of food restriction and exercise on spatial learning and open field exploration of female ratsTara Gunkali Chowdhury, André Antonio Fenton, Chiye J. Aoki · 2020 · Hippocampus
- Testing Links of Food-Related Olfactory Perception to Peripheral Ghrelin and Leptin ConcentrationsRachel Ginieis, Sashie Abeywickrema, Indrawati Oey, Mei Peng · 2022 · Frontiers in Nutrition
- Combined estrogen and ghrelin administration restores number of blood vessels and collagen type I/III ratio in the urethral and anal canal submucosa of old ovariectomized ratsDiaa E. E. Rizk, Hazem A. Hassan, Ahmed H. Al-Marzouqi · 2007 · International Urogynecology Journal
- Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive declineTian, Jing, Guo, Lan, Wang, Tienju, Jia, Kun, Swerdlow, Russell H., Zigman, Jeffrey M., Du, Heng · 2023 · JCI Insight
- Hypothalamic-pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: A test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe/PS1dE9 miceBreanna N. Harris, Breanna R. Roberts, Giuliana M. DiMarco, Kaylee Alers Maldonado, Zenobia Okwunwanne, Alena V. Savonenko, Paul L. Soto · 2022 · General and Comparative Endocrinology
- Metabolic demand stimulates CREB signaling in the limbic cortex: Implication for the induction of hippocampal synaptic plasticity by intrinsic stimulus for survivalNelly M. Estrada · 2009 · Frontiers in Systems Neuroscience
- Leptin, a tool of parasites?Mare Lõhmus, Sharon Moalem, Mats Björklund · 2012 · Biology Letters
- Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human modelsXulai Shi, Kaiyu Guan, Xuyan Peng, Bingru Xu, Xian-Yong Zhou, Shao Wang, Shengnan Xu, Miaomiao Zheng, Jing Yang Huang, Xiaoyang Wan et al. · 2021 · Brain Behavior and Immunity
- Systemic Ghrelin Treatment Induces Rapid, Transient, and Asymmetric Changes in the Metabolic Activity of the Mouse BrainPablo Nicolás De Francesco, Gimena Fernández, Maia Uriarte, Leandro Urrutia, Magdalena Ponce de León, Jean‐Alain Fehrentz, Germán Falasco, Mario Perelló · 2022 · Neuroendocrinology
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolismRomana Stark, Harry Dempsey, Elizabeth A. Kleeman, Martina Sassi, Sherri L. Osborne-Lawrence, Sepideh Sheybani-Deloui, Helen J. Rushby, Christen Kerry Mirth, Karl Austin‐Muttitt, Jonathan G.L. Mullins et al. · 2024 · Molecular Metabolism
- Nutrition and the Aging MaleJohn Edward Morley · 2010 · Clinics in Geriatric Medicine
- Ghrelin receptor activity amplifies hippocampal N‐methyl‐ d ‐aspartate receptor‐mediated postsynaptic currents and increases phosphorylation of the GluN1 subunit at Ser896 and Ser897Brandon G. Muniz, Masako Isokawa · 2015 · European Journal of Neuroscience
- Effect of potatoes and other carbohydrate-containing foods on cognitive performance, glycemic response, and satiety in childrenJennifer J. Lee, Neil R. Brett, Vincent C.H. Wong, Julia O. Totosy de Zepetnek, Alexandra Jasmine Fiocco, Nick Bellissimo · 2019 · Applied Physiology, Nutrition, and Metabolism
- Anti-inflammatory Effect of Ghrelin in Lymphoblastoid Cell Lines From Children With Autism Spectrum DisorderYasunori Yamashita, Manabu Makinodan, Michihiro Toritsuka, Takahira Yamauchi, Daisuke Ikawa, Sohei Kimoto, Takashi Komori, Ryohei Takada, Yoshinori Kayashima, Kaori Hamano-Iwasa et al. · 2019 · Frontiers in Psychiatry
- Recent progress in the discovery of ghrelin O -acyltransferase (GOAT) inhibitorsMalliga R. Iyer, Casey M. Wood, George Kunos · 2020 · RSC Medicinal Chemistry
- Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-level rapeseed meal diet in Chinese perch (Siniperca chuatsi)Jiao Li, Xu‐Fang Liang, Muhammad Shoaib Alam, Haocan Luo, Yanpeng Zhang, Binbin Peng, Qianqian Xiao, Zhilu Zhang, Liwei Liu, Shan He · 2021 · Journal of Comparative Physiology B
- Cognitive effects of acute restraint stress in male albino rats and the impact of pretreatment with quetiapine versus ghrelinShaimaa Nasr Amin, Sarah Mahmoud Gamal, Reham Shehab El Nemr Esmail, Tarek Mohamed Abdel Aziz, Laila Ahmed Rashed · 2014 · Journal of Integrative Neuroscience
- The use of conditioned place preference to determine broiler preferences for quantitative or qualitative dietary restrictionLouise Anne Buckley, V. Sandilands, P.M. Hocking, B.J. Tolkamp, Richard B. D’Eath · 2012 · British Poultry Science
- GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat HippocampusZohreh Ataie, Shirin Babri, Mina Ghahramanian Golzar, Hadi Ebrahimi, Fariba Mirzaei, Gisou Mohaddes · 2013 · Europe PMC (PubMed Central)
- Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophagesTian, Rong, Mao, Gengsheng · 2022 · European Journal of Histochemistry
- Parkinson’s disease and the gut-brain connection: unveiling pathways, mechanisms and promising therapiesSuhas Hajare, Yogesh Anant Kulkarni · 2025 · Brain Research
- Ghrelin system in Alzheimer's diseaseJing Tian, Tienju Wang, Heng Du · 2022 · Current Opinion in Neurobiology
- Attenuating the effect of Ghrelin on memory storage via bilateral reversible inactivation of the basolateral amygdaleFatemeh Goshadrou, Abdolaziz Ronaghi · 2012 · Behavioural Brain Research
- Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of miceEugenia Mercedes Luque, Valeria Paola Carlini, L. Vincenti, P. B. Puechagut, G. Stutz, María Emilia Santillán, Rubén Daniel Ruiz, Ana Carolina Martini, Marta Fiol de Cúneo · 2010 · Reproduction Fertility and Development
- Local injection of d -lys-3-GHRP-6 in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidationSiamak Beheshti, Neda Aslani · 2017 · Neuropeptides
- Differential Effects of a Full and Biased Ghrelin Receptor Agonist in a Mouse Kindling ModelAn Buckinx, Yana Van Den Herrewegen, Anouk Pierre, Eleonora Cottone, Khoubaib Ben Haj Salah, Jean‐Alain Fehrentz, Ron Kooijman, Dimitri De Bundel, Ilse Julia Smolders · 2019 · International Journal of Molecular Sciences
- Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsisAline Alves de Jesus, Patrícia Passaglia, Bruna M. Santos, Isabelle Rodrigues‐Santos, Rafael Flores, Marcelo E. Batalhão, Angelita Maria Stabile, Evelin Capellari Cárnio · 2020 · Brain Research
- Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum DisorderÇağla Çelikkol Sadıç, Ayhan Bi̇lgi̇ç, İbrahim Kılınç, Mehmet Burhan Oflaz, Tamer Baysal · 2020 · Journal of Autism and Developmental Disorders
- Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and DiseaseChihiro Yamada · 2021 · International Journal of Molecular Sciences
- Ghrelin mediated regulation of neurosynaptic transmitters in depressive disordersMilind V. Masule, Sumit Rathod, Yogeeta O. Agrawal, Chandragouda Raosaheb Patil, Kartik Tularam Nakhate, Shreesh Kumar Ojha, Sameer N. Goyal, Umesh B. Mahajan · 2022 · Current Research in Pharmacology and Drug Discovery
- Obesity‐Related Hormones in Low‐Income Preschool‐Age Children: Implications for School ReadinessAlison L. Miller, Carey Nien-Kai Lumeng, Jennifer L. DelProposto, Brian Florek, Kristin Wendorf, Julie C. Lumeng · 2013 · Mind Brain and Education
- Non-nutritional uses of nutrientsRichard Jay Wurtman · 2011 · European Journal of Pharmacology
- Ghrelin decreases motor deficits after traumatic brain injury.Nicole E. Lopez, G. Lindsay, L. Karina, Hageny A Mary, James G. Putnam, B. Eliceiri, R. Coimbra, V. Bansal · 2014 · Journal of Surgical Research
- A Role for Central Nervous Growth Hormone-Releasing Hormone Signaling in the Consolidation of Declarative MemoriesManfred Hallschmid, Ines Wilhelm, Christian Michel, Boris Perras, Jan Born A · 2011 · PLoS ONE
- Refined carbohydrate intake in relation to non-verbal intelligence among Tehrani schoolchildrenAmin Salehi‐Abargouei, Naser Kalantari, Nasrin Omidvar, Bahram Rashidkhani, A Houshyarrad, Azizeh Afkham Ebrahimi, Hossein Khosravi‐Boroujeni, Ahmad Esmaillzadeh · 2011 · Public Health Nutrition
- Olfactory Ensheathing Cells express both Ghrelin and Ghrelin Receptor in vitro: a new hypothesis in favor of a neurotrophic effectCristina Russo, Martina Patanè, Nunzio Vicario, Virginia Di Bella, Ilaria Cosentini, Vincenza Barresi, Rosario Gulino, Rosalia Pellitteri, Antonella Russo, Stefania Stanzani · 2019 · Neuropeptides
- Growth Hormone and Insulin-Like Growth Factor I: Effects on the BrainZvi Laron · 2009 · Elsevier eBooks
- The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in miceLuke D. Roberts, A. Hornsby, A. Thomas, Martina Sassi, Aimee Kinzett, Nathan Hsiao, Bethan R. David, M. Good, T. Wells, J. Davies · 2022 · bioRxiv
- Can we improve care for patients with dementia?John Edward Morley · 2011 · The journal of nutrition health & aging
- Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)Kazunori Kawamura, Masayuki Fujinaga, Yoko Shimoda et al. · 2017 · Nuclear Medicine and Biology
- Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in miceJulieta Paola Aguggia, María Paula Cornejo, Gimena Fernández, Pablo Nicolás De Francesco, Bharath Kumar Mani, Daniela Cassano, Agustina Cabral, Spring Valdivia, Guadalupe García Romero, Mirta Beatriz Reynaldo et al. · 2022 · Psychoneuroendocrinology
- Neurotensin promotes the dendrite elongation and the dendritic spine maturation of the cerebral cortex in vitroChihiro Gandou, Akiko Ohtani, Kouji Senzaki, Takashi Shiga · 2009 · Neuroscience Research
- The GHR-R antagonist JMV 2959 neither induces malaise nor alters the malaise property of LiCl in the adult male ratJuan A. Rodriguez, Jean‐Alain Fehrentz, Jean Martínez, Khoubaib Ben Haj Salah, Paul Jeff Wellman · 2017 · Physiology & Behavior
- Relationship Between Psychological Distress and Cognitive Function Differs as a Function of Obesity Status in Inpatient Heart FailureAlice Valiant Ely, Courtney Alio, Desirée C. Bygrave, Marykate Burke, Earl Walker · 2020 · Frontiers in Psychology
- Targeting the Ghrelin Receptor as a Novel Therapeutic Option for EpilepsyAn Buckinx, Dimitri De Bundel, Ron Kooijman, Ilse Julia Smolders · 2021 · Biomedicines
- RETRACTED: Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brainLuanna Dixson, Henrik Walter, Michael Schneider, Susanne Erk, Axel Schäfer, Leila Haddad, Oliver Grimm, Manuel Mattheisen, Markus Maria Nöthen, Sven Cichon et al. · 2014 · Proceedings of the National Academy of Sciences · Retracted
- Ghrelin potentiates cardiac reactivity to stress by modulating sympathetic control and beta-adrenergic responseGabriel Camargo-Silva, Larissa Córdova Turones, Kellen Rosa da Cruz, Karina Pereira Gomes, Michelle Mendanha Mendonça, Allancer Nunes, Itamar Couto Guedes de Jesus, Diego Basile Colugnati, Aline Priscila Pansani, Roger L.H. Pobbe et al. · 2018 · Life Sciences
- Emulation of synaptic behaviors using amorphous indium-gallium-zinc-oxide-based photoelectric synaptic devicesMinkyung Lee, Seungho Song, Yong‐Hoon Kim · 2019 · Japanese Journal of Applied Physics
- Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptorHarriët Schellekens, Orla A. McNamara, Timothy G. Dinan, Justin V. McCarthy, Gerard P. McGlacken, John F. Cryan · 2012 · Journal of Pharmacy and Pharmacology
- Plasma ghrelin levels in children with cystic fibrosis and healthy childrenMaryam Monajemzadeh, Shahrzad Mokhtari, Farzaneh Motamed · 2012 · Archives of Medical Science
- Food‐Restriction Lowers the Acoustic Startle Response in both Male and Female Rats, and, in Combination with Acute Ghrelin Injection, Abolishes the Expression of Fear‐Potentiated Startle in Male RatsDonna J. Toufexis, Olga Lipatova, Anthony C. Johnson, Alfonso B. Abizaid · 2016 · Journal of Neuroendocrinology
- Serum C-Peptide, Visfatin, Resistin, and Ghrelin are Altered in Sporadic and GRN-Associated Frontotemporal Lobar DegenerationRoberta Zanardini, Luisa Benussi, Silvia Fostinelli, Claudia Saraceno, Miriam Ciani, Barbara Borroni, Alessandro Padovani, Giuliano Gb. Binetti, Roberta Ghidoni · 2017 · Journal of Alzheimer s Disease
- The Potential Role of Gut Peptide Hormones in Autism Spectrum DisorderXin‐Rui Qi, Li Zhang · 2020 · Frontiers in Cellular Neuroscience
- Ghrelin treatment leads to dendritic spine remodeling in hippocampal neurons and increases the expression of specific BDNF-mRNA speciesM.L. Perea Vega, Michelle Lenardón Sánchez, Guillermo Fernández, María Gabriela Paglini, Mauricio G. Martín, Susana Rubiales de Barioglio · 2021 · Neurobiology of Learning and Memory
- Novel domain-selective ACE-inhibiting activity of synthetic growth hormone secretagoguesAntonio Torsello, Elena Bresciani, Monica Ravelli, Laura Rizzi, Ilaria Bulgarelli, Giorgio Ricci, Barbara Ghiazza, Marina Del Puppo, Veronica Mainini, Robert J. Omeljaniuk et al. · 2012 · Pharmacological Research
- The growth hormone secretagogue hexarelin increases cell proliferation in neurogenic regions of the mouse hippocampusAnna Barlind, Niklas Karlsson, N. David Åberg, Thomas Björk‐Eriksson, Klas Blomgren, Jörgen Isgaard · 2009 · Growth Hormone & IGF Research
- Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMIAbhishek Tyagi, Shih-Ying Wu, Jee-Won Kim, Ravindra Pramod Deshpande, Kerui Wu, Eleanor C. Smith, Giuseppe Luigi Banna, Kounosuke Watabe · 2025 · Nature Communications
- Local infusion of ghrelin into the lateral amygdala blocks extinction of conditioned taste aversion in ratsGe Song, Qianqian Zhu, Fubing Han, Shuai Liu, Chenyang Zhao, Yu Zhou · 2017 · Neuroscience Letters
- Functional group and stereochemical requirements for substrate binding by ghrelin O-acyltransferase revealed by unnatural amino acid incorporationElizabeth R. Cleverdon, Tasha R. Davis, James L. Hougland · 2018 · Bioorganic Chemistry
- Ghrelin Acylation—A Post-Translational Tuning Mechanism Regulating Adult Hippocampal NeurogenesisMartina Sassi, Alwena H. Morgan, Jeffrey S. Davies · 2022 · Cells
- Ghrelin infusion into the basolateral amygdala suppresses CTA memory formation in rats via the PI3K/Akt/mTOR and PLC/PKC signaling pathwaysMing Yu, Qianqian Zhu, Minglu Niu, Nan Li, Bai-qing Ren, Tengbo Yu, Zhishang Zhou, Jidong Guo, Yu Zhou · 2022 · Acta Pharmacologica Sinica
- Favorable Impact on Stress-Related Behaviors by Modulating Plasma ButyrylcholinesteraseStephen Brimijoin, Susannah J. Tye · 2017 · Cellular and Molecular Neurobiology
- Serum Ghrelin Is Associated with Verbal Learning and Adiposity in a Sample of Healthy, Fit Older AdultsDavid Michael Bellar, Ellen L. Glickman, Lawrence W. Judge · 2013 · BioMed Research International
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- Differential expression of the ghrelin-related mRNAs GHS-R1a, GHS-R1b, and MBOAT4 in Japanese patients with schizophreniaShunsuke Nakata, Yuta Yoshino, Mitsuo Okita, Kentaro Kawabe, Kiyohiro Yamazaki, Yuki Ozaki, Yoko Mori, Shinichiro Ochi, Jun‐ichi Iga, Shuichi Ueno · 2018 · Psychiatry Research
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