Tschöp, Matthias H.

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 3,949

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,857

Definition and diagnostic criteria of clinical obesity

Rubino, F., Cummings, D. E., Eckel, R. H., Cohen, R. V., Wilding, J. P. H., Brown, W. A., Stanford, F. C., Batterham, R. L., Farooqi, I. S., Farpour-Lambert, N. J., et al. (2025) · The Lancet Diabetes & Endocrinology

Obesity and Health PracticesObesity, Physical Activity, Diet

Cited by 1,811

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 1,679

Ghrelin

Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism

Regulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth Factors

Cited by 1,034

Anti-obesity drug discovery: advances and challenges

Müller, T. D., Blüher, M., Tschöp, M. H., & DiMarchi, R. D. (2022) · Nature Reviews Drug Discovery

Pharmacology and Obesity TreatmentRegulation of Appetite and Obesity

Cited by 1,021

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 984

Ghrelin controls hippocampal spine synapse density and memory performance

Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience

Regulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

Cited by 828

A guide to analysis of mouse energy metabolism

Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., et al. (2012) · Nature Methods

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 813

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 710

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Finan, B., Ma, T., Ottaway, N., Müller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., et al. (2013) · Science Translational Medicine

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 696

Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics

Barrier Structure and Function StudiesRegulation of Appetite and Obesity

Cited by 691

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 678

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Finan, B., Yang, B., Ottaway, N., Smiley, D. L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K. M., Fischer, K., et al. (2015) · Nature Medicine

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 645

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., et al. (2009) · Nature Chemical Biology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 641

The metabolic actions of glucagon revisited

Habegger, K. M., Heppner, K. M., Geary, N., Bartness, T. J., DiMarchi, R., & Tschöp, M. H. (2010) · Nature Reviews Endocrinology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 406

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice

Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 401

The central melanocortin system directly controls peripheral lipid metabolism

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 396

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

Huypens, P., Sass, S., Wu, M., Dyckhoff, D., Tschöp, M., Theis, F., Marschall, S., de Angelis, M. H., & Beckers, J. (2016) · Nature Genetics

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 366

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z.-W., Zimmer, M. R., Jeong, J. K., Szigeti-Buck, K., et al. (2014) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 336

Cannabinoids, opioids and eating behavior: The molecular face of hedonism?

Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006) · Brain Research Reviews

Cannabis and Cannabinoid ResearchRegulation of Appetite and Obesity

Cited by 330

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Zhang, Q., Delessa, C. T., Augustin, R., Bakhti, M., Colldén, G., Drucker, D. J., Feuchtinger, A., Caceres, C. G., Grandl, G., Harger, A., et al. (2021) · Cell Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 322

The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes

Frias, J. P., Bastyr, E. J., Vignati, L., Tschöp, M. H., Schmitt, C., Owen, K., Christensen, R. H., & DiMarchi, R. D. (2017) · Cell Metabolism

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 321

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat

Davis, J. F., Tracy, A. L., Schurdak, J. D., Tschöp, M. H., Lipton, J. W., Clegg, D. J., & Benoit, S. C. (2008) · Behavioral Neuroscience

Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

Cited by 307