The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Open accessAbstract
Insulin signaling in the hypothalamus plays a role in maintaining body weight. Studies suggest that the forkhead transcription factor Foxo1 is an important mediator of insulin signaling in peripheral tissues. Here we demonstrate that in normal mice, hypothalamic Foxo1 expression is reduced by the anorexigenic hormones insulin and leptin. These hormones' effects on feeding are inhibited when hypothalamic Foxo1 is activated, establishing a new signaling pathway through which insulin and leptin regulate food intake in hypothalamic neurons. Moreover, activation of Foxo1 in the hypothalamus increases food intake and body weight, whereas inhibition of Foxo1 decreases both. Foxo1 stimulates the transcription of the orexigenic neuropeptide Y and Agouti-related protein through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway, but suppresses the transcription of anorexigenic proopiomelanocortin by antagonizing the activity of signal transducer–activated transcript-3 (STAT3). Our data suggest that hypothalamic Foxo1 is an important regulator of food intake and energy balance.
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Cites
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114
PI3K integrates the action of insulin and leptin on hypothalamic neurons
Xu, A. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524301 · Cited by 420
Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328
Kim, M. S., Small, C. J., Stanley, S. A., Morgan, D. G. A., Seal, L. J., Kong, W. M., Edwards, C. M. B., Abusnana, S., Sunter, D., Ghatei, M. A., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8857 · Cited by 256
Self-citationMorton, G. J., Niswender, K. D., Rhodes, C. J., Myers, M. G., Blevins, J. E., Baskin, D. G., & Schwartz, M. W. (2003) · Endocrinology · doi:10.1210/en.2002-0115 · Cited by 158
Cited by
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350
Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170
FoxO transcription factors in the maintenance of cellular homeostasis during aging
Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604
Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426
Metadata
- Authors
- Kim, M.-S., Pak, Y. K., Jang, P.-G., Namkoong, C., Choi, Y.-S., Won, J.-C., Kim, K.-S., Kim, S.-W., Kim, H.-S., Park, J.-Y., Kim, Y.-B., & Lee, K.-U.
- Venue
- Nature Neuroscience
- Published
- 2006-06-18
- Volume
- 9
- Issue
- 7
- Pages
- 901-906
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2050418518
- Cited by
- 332
- References
- 7
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, M.-S., Pak, Y. K., Jang, P.-G., Namkoong, C., Choi, Y.-S., Won, J.-C., Kim, K.-S., Kim, S.-W., Kim, H.-S., Park, J.-Y., Kim, Y.-B., & Lee, K.-U. (2006). Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nature Neuroscience. https://doi.org/10.1038/nn1731
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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