FoxO transcription factors in the maintenance of cellular homeostasis during aging
Open accessAbstract
The FoxO family of Forkhead transcription factors functions at the interface of tumor suppression, energy metabolism, and organismal longevity. FoxO factors are key downstream targets of insulin, growth factor, nutrient, and oxidative stress stimuli that coordinate a wide range of cellular outputs. FoxO-dependent cellular responses include gluconeogenesis, neuropeptide secretion, atrophy, autophagy, apoptosis, cell cycle arrest, and stress resistance. This review will discuss the roles of the mammalian FoxO family in a variety of cell types, from stem cells to mature cells, in the context of the whole organism. Given the overwhelming evidence that the FoxO factors promote longevity in invertebrates, this review will also discuss the potential role of the FoxO factors in the aging of mammalian organisms.
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Other factors that promote longevity in invertebrates, such as the Foxo family of Forkhead transcription factors, also upregulate macroautophagy.
“Other factors that promote longevity in invertebrates, such as the Foxo family of Forkhead transcription factors, also upregulate macroautophagy (Salih and Brunet, 2008).”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Salih and Brunet, 2008
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- Authors
- Salih, D. A., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 20
- Issue
- 2
- Pages
- 126-136
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC2387118
- OpenAlex
- W2098845312
- Cited by
- 604
- References
- 14
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 19 · 2023: 21 · 2022: 27 · 2021: 29 · 2020: 21 · 2019: 27 · 2018: 28 · 2017: 32 · 2016: 39 · 2015: 41 · 2014: 37 · 2013: 51 · 2012: 50
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute on Aging (R01AG026648)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- FOXO transcription factors, forkhead transcription factor, aging, cellular homeostasis, longevity, insulin signaling, growth factor signaling, nutrient signaling, oxidative stress, stress tolerance, autophagy, apoptosis, cell cycle arrest, stem cells, energy metabolism, gluconeogenesis, neuropeptide release, atrophy
- MeSH terms
- Aging, Animals, Homeostasis, Humans, Invertebrates, Models, Biological, Neovascularization, Pathologic, Forkhead Transcription Factors
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