A role for inhibition in shaping the temporal flow of information in prefrontal cortex
Abstract
The prefrontal cortex is important in guiding or inhibiting future responses, which requires the temporal integration of events and which provides continuity to the thought process. No cellular mechanism has been proposed to explain how the mental representation of a response or idea is linked to the next. Using simultaneous recordings in monkeys, we revealed inhibitory interactions between neurons active at different time points relative to the cue presentation, delay interval and response period of a working memory task. These findings suggest an important role of inhibition in the cerebral cortex-controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bilateral dorsolateral prefrontal cortex is known to be involved in working memory and goal-directed control of attention.
“Consistent with this functional connectivity, bilateral DLPFC is known to be involved in working memory (e.g., Champod & Petrides 2007; Constantinidis et al. 2002) and in the goal-directed control of attention (e.g., Rainer et al. 1998; see Miller 2000).”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Constantinidis et al. 2002
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 42 · Cited by 348
- Authors
- Constantinidis, C., Williams, G. V., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- Venue
- Nature Neuroscience
- Published
- 2002-01-22
- Volume
- 5
- Issue
- 2
- Pages
- 175-180
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1971198017
- Cited by
- 348
- References
- 42
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 5 · 2018: 13 · 2017: 7 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 16 · 2012: 12
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH38546)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- prefrontal cortex, neuronal inhibition, temporal integration, working memory, neuronal synchronization, retention interval, response timing, neuronal interactions
- MeSH terms
- Animals, Haplorhini, Cues, Memory, Neural Inhibition, Neurons, Reaction Time, Time Factors, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
