The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Electrostatic focusing of unlabelled DNA into nanoscale pores using a salt gradient
Open accessAbstract
Solid-state nanopores are sensors capable of analyzing individual unlabelled DNA molecules in solution. While the critical information obtained from nanopores (e.g., DNA sequence) is the signal collected during DNA translocation, the throughput of the method is determined by the rate at which molecules arrive and thread into the pores. Here we study the process of DNA capture into nanofabricated silicon nitride pores of molecular dimensions. For fixed analyte concentrations we find an increase in capture rate as the DNA length increases from 800 to 8,000 basepairs, a length-independent capture rate for longer molecules, and increasing capture rates when ionic gradients are established across the pore. In addition, we show that application of a 20-fold salt gradient enables detection of picomolar DNA concentrations at high throughput. The salt gradients enhance the electric field, focusing more molecules into the pore, thereby advancing the possibility of analyzing unamplified DNA samples using nanopores.
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Cites
The potential and challenges of nanopore sequencing
Branton, D., Deamer, D. W., Marziali, A., Bayley, H., Benner, S. A., Butler, T., Di Ventra, M., Garaj, S., Hibbs, A., Huang, X., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt.1495 · Cited by 2,534
Self-citationContinuous base identification for single-molecule nanopore DNA sequencing
Clarke, J., Wu, H.-C., Jayasinghe, L., Patel, A., Reid, S., & Bayley, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.12 · Cited by 1,810
DNA molecules and configurations in a solid-state nanopore microscope
Li, J., Gershow, M., Stein, D., Brandin, E., & Golovchenko, J. A. (2003) · Nature Materials · doi:10.1038/nmat965 · Cited by 936
Salt Dependence of Ion Transport and DNA Translocation through Solid-State Nanopores
Smeets, R. M. M., Keyser, U. F., Krapf, D., Wu, M., Dekker, N. H., & Dekker, C. (2005) · Nano Letters · doi:10.1021/nl052107w · Cited by 857
Fast DNA Translocation through a Solid-State Nanopore
Storm, A. J., Storm, C., Chen, J., Zandbergen, H., Joanny, J.-F., & Dekker, C. (2005) · Nano Letters · doi:10.1021/nl048030d · Cited by 733
DNA Translocation Governed by Interactions with Solid-State Nanopores
Wanunu, M., Sutin, J. D. B., McNally, B., Chow, A., & Meller, A. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.140475 · Cited by 504
Self-citationDriven DNA Transport into an Asymmetric Nanometer-Scale Pore
Henrickson, S. E., Misakian, M., Robertson, B., & Kasianowicz, J. J. (2000) · Physical Review Letters · doi:10.1103/physrevlett.85.3057 · Cited by 501
Probing Single DNA Molecule Transport Using Fabricated Nanopores
Chen, P., Gu, J., Brandin, E., Kim, Y.-R., Wang, Q., & Branton, D. (2004) · Nano Letters · doi:10.1021/nl048654j · Cited by 387
Chemically Modified Solid-State Nanopores
Wanunu, M., & Meller, A. (2007) · Nano Letters · doi:10.1021/nl070462b · Cited by 375
Self-citationSingle molecule measurements of DNA transport through a nanopore
Meller, A., & Branton, D. (2002) · ELECTROPHORESIS · doi:10.1002/1522-2683(200208)23:16<2583::aid-elps2583>3.0.co;2-h · Cited by 374
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Cited by
Identification of single nucleotides in MoS2 nanopores
Feng, J., Liu, K., Bulushev, R. D., Khlybov, S., Dumcenco, D., Kis, A., & Radenovic, A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.219 · Cited by 512
Single-molecule protein sensing in a nanopore: a tutorial
Varongchayakul, N., Song, J., Meller, A., & Grinstaff, M. W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00106e · Cited by 282
Self-citationMcNally, B., Singer, A., Yu, Z., Sun, Y., Weng, Z., & Meller, A. (2010) · Nano Letters · doi:10.1021/nl1012147 · Cited by 270
Self-citationSteep pH gradients and directed colloid transport in a microfluidic alkaline hydrothermal pore
Möller, F. M., Kriegel, F., Kieß, M., Sojo, V., & Braun, D. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201610781 · Cited by 78
Breton, M. F., Discala, F., Bacri, L., Foster, D., Pelta, J., & Oukhaled, A. (2013) · The Journal of Physical Chemistry Letters · doi:10.1021/jz400938q · Cited by 63
Metadata
- Authors
- Wanunu, M., Morrison, W., Rabin, Y., Grosberg, A. Y., & Meller, A.
- Venue
- Nature Nanotechnology
- Published
- 2009-12-20
- Volume
- 5
- Issue
- 2
- Pages
- 160-165
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2059648430
- Cited by
- 745
- References
- 16
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- green
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