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Controlling protein translocation through nanopores with bio-inspired fluid walls
Open accessAbstract
Synthetic nanopores have been used to study individual biomolecules in high thoroughput but their performance as sensors does not match biological ion channels. Controlling the translocation times of single-molecule analytes and their non-specific interaction with pore walls remain a challenge. Inspired by the olfactory sensilla of the insect antenna, here we show that coating nanopores with fluid bilayer lipids allows the pore diameters to be fine-tuned in sub-nanometre increments. Incorporation of mobile ligands in the lipid conferred specificity and slowed down the translocation of targeted proteins sufficiently to time-resolve translocation events of individual proteins. The lipid coatings also prevented pores from clogging, eliminated non-specific binding and enabled the translocation of amyloid-beta (Aβ) oligomers and fibrils. Through combined analysis of translocation time, volume, charge, shape and ligand affinity, different proteins were identified.
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Cites
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015
Cited by
Nanopore-based technologies beyond DNA sequencing
Ying, Y.-L., Hu, Z.-L., Zhang, S., Qing, Y., Fragasso, A., Maglia, G., Meller, A., Bayley, H., Dekker, C., & Long, Y.-T. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01193-2 · Cited by 538
Identification of single nucleotides in MoS2 nanopores
Feng, J., Liu, K., Bulushev, R. D., Khlybov, S., Dumcenco, D., Kis, A., & Radenovic, A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.219 · Cited by 512
Single-molecule protein sensing in a nanopore: a tutorial
Varongchayakul, N., Song, J., Meller, A., & Grinstaff, M. W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00106e · Cited by 282
Transport mechanisms in nanopores and nanochannels: can we mimic nature?
Tagliazucchi, M., & Szleifer, I. (2015) · Materials Today · doi:10.1016/j.mattod.2014.10.020 · Cited by 269
Metadata
- Authors
- Yusko, E. C., Johnson, J. M., Majd, S., Prangkio, P., Rollings, R. C., Li, J., Yang, J., & Mayer, M.
- Venue
- Nature Nanotechnology
- Published
- 2011-02-20
- Volume
- 6
- Issue
- 4
- Pages
- 253-260
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2097065797
- Cited by
- 660
- References
- 1
- FWCI
- 25.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Yusko, E. C., Johnson, J. M., Majd, S., Prangkio, P., Rollings, R. C., Li, J., Yang, J., & Mayer, M. (2011). Controlling protein translocation through nanopores with bio-inspired fluid walls. Nature Nanotechnology. https://doi.org/10.1038/nnano.2011.12
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