The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Universal computing by DNA origami robots in a living animal
Open accessAbstract
Biological systems are collections of discrete molecular objects that move around and collide with each other. Cells carry out elaborate processes by precisely controlling these collisions, but developing artificial machines that can interface with and control such interactions remains a significant challenge. DNA is a natural substrate for computing and has been used to implement a diverse set of mathematical problems1-3, logic circuits4-6 and robotics7-9. The molecule also naturally interfaces with living systems, and different forms of DNA-based biocomputing have previously been demonstrated10-13. Here we show that DNA origami14-16 can be used to fabricate nanoscale robots that are capable of dynamically interacting with each other17-18 in a living animal. The interactions generate logical outputs, which are relayed to switch molecular payloads on or off. As a proof-of-principle, we use the system to create architectures that emulate various logic gates (AND, OR, XOR, NAND, NOT, CNOT, and a half adder). Following an ex vivo prototyping phase, we successfully employed the DNA origami robots in living cockroaches (Blaberus discoidalis) to control a molecule that targets the cells of the animal.
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Cites
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Cited by
DNA nanotechnology from the test tube to the cell
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Photo- and Redox-Driven Artificial Molecular Motors
Baroncini, M., Silvi, S., & Credi, A. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00291 · Cited by 538
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
Metadata
- Authors
- Amir, Y., Ben-Ishay, E., Levner, D., Ittah, S., Abu-Horowitz, A., & Bachelet, I.
- Venue
- Nature Nanotechnology
- Published
- 2014-04-06
- Volume
- 9
- Issue
- 5
- Pages
- 353-357
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2165354120
- Cited by
- 373
- References
- 26
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Amir, Y., Ben-Ishay, E., Levner, D., Ittah, S., Abu-Horowitz, A., & Bachelet, I. (2014). Universal computing by DNA origami robots in a living animal. Nature Nanotechnology. https://doi.org/10.1038/nnano.2014.58
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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