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A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Abstract
Nanorobots Deliver: DNA aptamers are short strands that have high binding affinity for a target protein that can be used as triggers for releasing cargo from delivery vehicles. Douglas et al. (p. 831 ) used this strategy to design DNA origami “nanorobots”—complex shaped structures created by manipulating a long DNA strand through binding with shorter “staple” strands—that could deliver payloads such as gold nanoparticles or fluorescently labeled antibody fragments. These nanorobots were designed to open in response to specific cell-surface proteins, releasing molecules that triggered cell signaling.
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Cited by
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Programmable materials and the nature of the DNA bond
Jones, M. R., Seeman, N. C., & Mirkin, C. A. (2015) · Science · doi:10.1126/science.1260901 · Cited by 1,347
A Comprehensive Survey of Recent Advancements in Molecular Communication
Farsad, N., Yilmaz, H. B., Eckford, A., Chae, C.-B., & Guo, W. (2016) · IEEE Communications Surveys & Tutorials · doi:10.1109/comst.2016.2527741 · Cited by 968
Large-scale de novo DNA synthesis: technologies and applications
Kosuri, S., & Church, G. M. (2014) · Nature Methods · doi:10.1038/nmeth.2918 · Cited by 869
Self-citation
Metadata
- Authors
- Douglas, S. M., Bachelet, I., & Church, G. M.
- Venue
- Science
- Published
- 2012-02-17
- Volume
- 335
- Issue
- 6070
- Pages
- 831-834
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976815031
- Cited by
- 2,180
- References
- 0
- FWCI
- 57.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
