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Cited by 1,400

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Multiscale photoacoustic microscopy and computed tomography

Open access
Wang, Lihong V.·2009·Nature Photonics

Abstract

Photoacoustic tomography (PAT) is probably the fastest growing biomedical imaging technology owing to its capability of high-resolution sensing of rich optical contrast in vivo at depths beyond the optical transport mean free path (~1 mm in the skin). Existing high-resolution optical imaging technologies, such as confocal microscopy and two-photon microscopy, have fundamentally impacted biomedicine but cannot reach such depths. Taking advantage of low ultrasonic scattering, PAT indirectly improves tissue transparency by 100 to 1000 fold and consequently enables deeply penetrating functional and molecular imaging at high spatial resolution. Further, PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.

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Metadata

Authors
Wang, L. V.
Venue
Nature Photonics
Published
2009-08-28
Volume
3
Issue
9
Pages
503-509
ISSN
  • 1749-4885 (ISSN-L)
  • 1749-4893
OpenAlex
W2068926508
Cited by
1,400
References
1
FWCI
43.28
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Multiscale photoacoustic microscopy and computed tomography. https://app.cochat.ai/papers/10.1038/nphoton.2009.157
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Wang, L. V. (2009). Multiscale photoacoustic microscopy and computed tomography. Nature Photonics. https://doi.org/10.1038/nphoton.2009.157

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