Synthesis, Characterization, and Biomedical Applications of a Targeted Dual-Modal Near-Infrared-II Fluorescence and Photoacoustic Imaging Nanoprobe
Abstract
Our development of multifunctional dual-modal imaging probes aims to integrate the benefits from both second near-infrared (NIR-II) fluorescence (1000-1700 nm) and photoacoustic imaging with an ultimate goal of improving overall cancer diagnosis efficacy. Herein we designed a donor-acceptor chromophore based nanoparticle (DAP) as a dual-modal image contrast agent has strong absorption in the NIR-I window and a strong fluorescence emission peak in the NIR-II region. The dual-modal DAPs composed of D-π-A-π-D-type chromophores were PEGylated through nanoprecipitation. The multifunctional DAP surface was thus available for subsequent bioconjugation of EGFR Affibody (Ac-Cys-Z EGFR:1907 ) to target EGFR-positive cancers. The Affibody-conjugated DAPs appeared as highly monodisperse nanoparticles (∼30 nm) with strong absorption in the NIR-I window (at ca. 680 nm) and an extremely high fluorescence in the NIR-II region (maximum peak at 1000 nm). Consequently, the Affibody-DAPs show significantly enhanced photoacoustic and NIR-II fluorescence contrast effects in both in vitro and in vivo experiments. Moreover, the Affibody-DAPs have the capability to selectively target EGFR-positive tumors in an FTC-133 subcutaneous mouse model with relatively high photoacoustic and fluorescent signals. By taking advantage of high spatial resolution and excellent temporal resolution, photoacoustic/NIR-II fluorescence imaging with targeted dual-modal contrast agents allows us to specifically image and d…
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Chen et al. prepared a novel NIR-II/PA multimodal probe based on the CH1055 derivative.
“Chen et al. prepared a novel NIR-II/PA multimodal probe based on the CH1055 derivative [195].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [195]
This bioimaging probe was encapsulated into amphiphilic PEGylated phospholipids (DSPE-PEG5000-NH2) in aqueous solution, then integrated with an engineered small protein anti-EGFR Affibody which can enhance the targeting efficiency for cancer cells.
“This bioimaging probe was encapsulated into amphiphilic PEGylated phospholipids (DSPE-PEG5000-NH2) in aqueous solution, then integrated with an engineered small protein anti-EGFR Affibody which can enhance the targeting efficiency for cancer cells.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [195]
Affibody-DAP can bind EGFR-positive tumors in FTC-133 subcutaneous mice model with excellent PA and NIR-II fluorescence signals.
“Affibody-DAP can bind EGFR-positive tumors in FTC-133 subcutaneous mice model with excellent PA and NIR-II fluorescence signals (Figure 13a).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [195]
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Self-citation
- Authors
- Cheng, K., Chen, H., Jenkins, C. H., Zhang, G., Zhao, W., Zhang, Z., Han, F., Fung, J., Yang, M., Jiang, Y., Xing, L., & Cheng, Z.
- Affiliations
- Stanford Medicine (US)
- Beijing Jiaotong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Xing, Lei
- Cheng, Zhen
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-12-11
- Volume
- 11
- Issue
- 12
- Pages
- 12276-12291
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2775348980
- Cited by
- 156
- References
- 41
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 14 · 2021: 28 · 2020: 26 · 2019: 32 · 2018: 16
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biological and Environmental Research (DE-SC0008397)
- Ministry of Education of the People's Republic of China (2017RC025)
- Ministry of Science and Technology of the People's Republic of China (2015DFA30440)
- Natural Science Foundation of Beijing Municipality (7164270)
- National Natural Science Foundation of China (61601019, 81301268)
- Beijing Nova Program (Z131107000413063)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- NIR-II fluorescence, photoacoustic imaging, dual-modality imaging, nanoprobes, donor-acceptor chromophores, cancer diagnosis, PEGylated nanoparticles, nanoprecipitation
- MeSH terms
- Animals, Cells, Cultured, Female, Fluorescence, Fluorescent Dyes, Humans, Infrared Rays, Mice, Nude, Neoplasms, Experimental, Biomedical Technology, Principal Component Analysis, Mice, Nanoparticles, Photoacoustic Techniques, Optical Imaging
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