The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Integrated elastomeric components for autonomous regulation of sequential and oscillatory flow switching in microfluidic devices
Open accessAbstract
A critical need for enhancing usability and capabilities of microfluidic technologies is the development of standardized, scalable, and versatile control systems1,2. Electronically controlled valves and pumps typically used for dynamic flow regulation, although useful, can limit convenience, scalability, and robustness3–5. This shortcoming has motivated development of device-embedded non-electrical flow-control systems. Existing approaches to regulate operation timing on-chip, however, still require external signals such as timed generation of fluid flow, bubbles, liquid plugs or droplets, or an alteration of chemical compositions or temperature6–16. Here, we describe a strategy to provide device-embedded flow switching and clocking functions. Physical gaps and cavities interconnected by holes are fabricated into a three-layer elastomer structure to form networks of fluidic gates that can spontaneously generate cascading and oscillatory flow output using only a constant flow of Newtonian fluids as the device input. The resulting microfluidic substrate architecture is simple, scalable, and should be applicable to various materials. This flow-powered fluidic gating scheme brings the autonomous signal processing ability of microelectronic circuits to microfluidics where there is the added diversity in current information of having distinct chemical or particulate species and richness in current operation of having chemical reactions and physical interactions.
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Citations
Cites
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Cited by
From 3D cell culture to organs-on-chips
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The upcoming 3D-printing revolution in microfluidics
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A soft, bistable valve for autonomous control of soft actuators
Rothemund, P., Ainla, A., Belding, L., Preston, D. J., Kurihara, S., Suo, Z., & Whitesides, G. M. (2018) · Science Robotics · doi:10.1126/scirobotics.aar7986 · Cited by 543
Digital logic for soft devices
Preston, D. J., Rothemund, P., Jiang, H. J., Nemitz, M. P., Rawson, J., Suo, Z., & Whitesides, G. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820672116 · Cited by 312
Metadata
- Authors
- Mosadegh, B., Kuo, C.-H., Tung, Y.-C., Torisawa, Y.-S., Bersano-Begey, T., Tavana, H., & Takayama, S.
- Venue
- Nature Physics
- Published
- 2010-04-18
- Volume
- 6
- Issue
- 6
- Pages
- 433-437
- ISSN
- 1745-2473 (ISSN-L)
- 1745-2481
- OpenAlex
- W2101273951
- Cited by
- 286
- References
- 11
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
