The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Femtosecond diffractive imaging with a soft-X-ray free-electron laser
Open accessAbstract
Theory predicts1,2,3,4 that, with an ultrashort and extremely bright coherent X-ray pulse, a single diffraction pattern may be recorded from a large macromolecule, a virus or a cell before the sample explodes and turns into a plasma. Here we report the first experimental demonstration of this principle using the FLASH soft-X-ray free-electron laser. An intense 25 fs, 4×1013 W cm−2 pulse, containing 1012 photons at 32 nm wavelength, produced a coherent diffraction pattern from a nanostructured non-periodic object, before destroying it at 60,000 K. A novel X-ray camera assured single-photon detection sensitivity by filtering out parasitic scattering and plasma radiation. The reconstructed image, obtained directly from the coherent pattern by phase retrieval through oversampling5,6,7,8,9, shows no measurable damage, and is reconstructed at the diffraction-limited resolution. A three-dimensional data set may be assembled from such images when copies of a reproducible sample are exposed to the beam one by one10.
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Citations
Cites
Potential for biomolecular imaging with femtosecond X-ray pulses
Neutze, R., Wouts, R., van der Spoel, D., Weckert, E., & Hajdu, J. (2000) · Nature · doi:10.1038/35021099 · Cited by 2,022
Self-citation
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Self-citationSingle mimivirus particles intercepted and imaged with an X-ray laser
Seibert, M. M., Ekeberg, T., Maia, F. R. N. C., Svenda, M., Andreasson, J., Jönsson, O., Odić, D., Iwan, B., Rocker, A., Westphal, D., et al. (2011) · Nature · doi:10.1038/nature09748 · Cited by 904
Self-citationFemtosecond electronic response of atoms to ultra-intense X-rays
Young, L., Kanter, E. P., Krässig, B., Li, Y., March, A. M., Pratt, S. T., Santra, R., Southworth, S. H., Rohringer, N., DiMauro, L. F., et al. (2010) · Nature · doi:10.1038/nature09177 · Cited by 792
Self-citationThree-Dimensional Reconstruction of the Giant Mimivirus Particle with an X-Ray Free-Electron Laser
Ekeberg, T., Svenda, M., Abergel, C., Maia, F. R. N. C., Seltzer, V., Claverie, J.-M., Hantke, M., Jönsson, O., Nettelblad, C., van der Schot, G., et al. (2015) · Physical Review Letters · doi:10.1103/physrevlett.114.098102 · Cited by 344
Self-citationThree-Dimensional Visualization of a Human Chromosome Using Coherent X-Ray Diffraction
Nishino, Y., Takahashi, Y., Imamoto, N., Ishikawa, T., & Maeshima, K. (2009) · Physical Review Letters · doi:10.1103/physrevlett.102.018101 · Cited by 306
Metadata
- Authors
- Chapman, H. N., Barty, A., Bogan, M. J., Boutet, S., Frank, M., Hau-Riege, S. P., Marchesini, S., Woods, B. W., Bajt, S., Benner, W. H., London, R. A., Plönjes, E., Kuhlmann, M., Treusch, R., Düsterer, S., Tschentscher, T., Schneider, J. R., Spiller, E., Möller, T., Bostedt, C., Hoener, M., Shapiro, D. A., Hodgson, K. O., van der Spoel, D., Burmeister, F., Bergh, M., Caleman, C., Huldt, G., Seibert, M. M., Maia, F. R. N. C., Lee, R. W., Szöke, A., Timneanu, N., & Hajdu, J.
- Venue
- Nature Physics
- Published
- 2006-11-12
- Volume
- 2
- Issue
- 12
- Pages
- 839-843
- ISSN
- 1745-2473 (ISSN-L)
- 1745-2481
- OpenAlex
- W2159759190
- Cited by
- 1,026
- References
- 1
- FWCI
- 57.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chapman, H. N., Barty, A., Bogan, M. J., Boutet, S., Frank, M., Hau-Riege, S. P., Marchesini, S., Woods, B. W., Bajt, S., Benner, W. H., London, R. A., Plönjes, E., Kuhlmann, M., Treusch, R., Düsterer, S., Tschentscher, T., Schneider, J. R., Spiller, E., Möller, T., . . . Hajdu, J. (2006). Femtosecond diffractive imaging with a soft-X-ray free-electron laser. Nature Physics. https://doi.org/10.1038/nphys461
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
