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The Effects of Nefazodone on Sleep Architecture in Depression

Armitage, Roseanne, Rush, A. John, Trivedi, Madhukar, Cain, John, Roffwarg, Howard P.·1994·Neuropsychopharmacology
DOI 10.1038/npp.1994.14
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Abstract

A polysomnographic study was conducted on 10 outpatients with major depression at baseline and during 4 to 8 weeks of open-trial treatment with nefazodone (400 to 600 mg/day). All 10 patients were treatment responders as evidenced by at least 50% reduction from baseline scores on the Hamilton Depression Rating Scale. Nefazodone was associated with significantly decreased wake and movement time and increased minutes and percentage of stage 2 sleep at the expense of light stage 1 sleep. Nefazodone did not increase rapid-eye-movement (REM) latency and it did not suppress REM sleep. In fact, a trend toward increased REM in the second REM period was observed, although decreased REM in the third REM period was also noted. In summary, nefazodone, an effective antidepressant, decreases arousals and wakefulness during sleep and reduces light non-REM sleep. This agent does not appear to suppress REM sleep or prolong REM latency in patients who respond to treatment.

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Crossref · 10.1038/npp.1994.14

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  • Disruption in sleep continuity was correlated with plasma levels of fluoxetine and its biologically active metabolite, norfluoxetine.

    “Moreover, disruption in sleep continuity was correlated with plasma levels of fluoxetine (a long half-life antidepressant) and its biologically active metabolite, norfluoxetine.”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Armitage et al., 1994

  • Fluoxetine administration resulted in a significant decrease in sleep efficiency.

    “Fluoxetine administration resulted in a significant decrease in sleep efficiency.”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Armitage et al., 1994

  • Nefazodone exerts minimal effects in altering sleep continuity measures; it either decreases awake and movement time and number of awakenings, increases sleep efficiency, or has no effect on these parameters, thus preserving sleep continuity.

    “First, nefazodone exerts minimal effects in altering sleep continuity measures.In this regard, nefazodone either decreases awake and movement time and number of awakenings, increases sleep efficiency, or has no effect on these parameters, thus preserving sleep continuity [Armitage et al., 1994[Armitage et al., , 1997;;Gillin et al., 1997;Sharpley et al., 1992Sharpley et al., , 1996;;Rush et al., 1”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Armitage et al., 1994

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Authors
Armitage, R., Rush, A. J., Trivedi, M., Cain, J., & Roffwarg, H. P.
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1994-04
Volume
10
Issue
2
Pages
123-127
ISSN
  • 0893-133X
  • 1740-634X
DOI
10.1038/npp.1994.14
Cited by
66
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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