The DOI matches its Crossref record; 71 of the 73 references it cites were found in a registry or an index.
Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
Open accessAbstract
Childhood trauma is associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and is a known risk factor for suicidal behavior. In this study we sought to determine whether the impact of childhood trauma on suicide risk might be modified by FKBP5, an HPA-axis regulating gene. Sixteen FKBP5 haplotype-tagging single nucleotide polymorphisms (SNPs) were genotyped in a sample of African Americans: 398 treatment-seeking patients with substance dependence (90% men; 120 suicide attempters) and 432 nonsubstance-dependent individuals (40% men; 21 suicide attempters). In all, 474 participants (112 suicide attempters) also completed the Childhood Trauma Questionnaire (CTQ). Primary haplotype analyses were conducted with the four SNPs implicated in earlier studies: rs3800373, rs9296158, rs1360780, and rs9470080. We found that childhood trauma was associated with suicide attempt (P<0.0001). Although there was no main effect of the two major yin yang haplotypes in the four SNP haplotype blocks, there was a haplotype influence on suicide risk (p=0.006) only in individuals exposed to high levels of childhood trauma. In this group, 51% with two copies of the risk haplotype, 36% with one copy, and 20% with no copies had attempted suicide. The total logistic regression model accounted for 13% of the variance in attempted suicide. Analyses of the 16 SNPs showed significant main effects on suicide attempt of rs3777747, rs4713902, and rs9470080 and interactive effects of rs3800373, rs9296158, and rs1360780 with CTQ score on suicide attempt. These data suggest that childhood trauma and variants of the FKBP5 gene may interact to increase the risk for attempting suicide.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Further clinical studies confirm minor alleles of FKBP5 being particularly sensitive and interact with ELS/CT to increase aggressive behavior (387), suicide attempts (388), and depression (389).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [388]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“Glucocorticoid receptors are subject to genetic effects via chaperone proteins like SKA1 and FKBP5 (58, 148, 149), as well as epigenetic changes (i.e., methylation) observed in response to maternal deprivation in rats (150) and in suicide decedents with a history of childhood adversity (60).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
Stephens, M., & Donnelly, P. (2003) · The American Journal of Human Genetics · doi:10.1086/379378 · Cited by 3,516
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Suicide as an outcome for mental disorders: A meta-analysis
Harris, E. C., & Barraclough, B. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.170.3.205 · Cited by 2,589
Validity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population
BERNSTEIN, D. P., AHLUVALIA, T., POGGE, D., & HANDELSMAN, L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00012 · Cited by 1,574
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977
Flagged first, then by citations
2 of the 73 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Beatrais A, Joyce P, Mulder R (1997). Precipitating factors and life events in serious suicide attempters among youth. J Am Acad Child Adolesc Psychiatry 36: 1543–1551.
- Bernstein D, Fink L (1998). Childhood Trauma Questionnaire: A Retrospective Self-Report Manual. The Psychological Corporation: San Antonio, TX.
Cited by
Sorted by citations
Items 201–281 of 281
Influence of Early Family Cohesion on Future Orientation
Zheng, L., & Gan, Y. (2018) · Journal of Individual Differences · doi:10.1027/1614-0001/a000260 · Cited by 7
The Long-Term Biological and Clinical Consequences of Child Abuse and Neglect
Parker, J., & Nemeroff, C. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00006-6 · Cited by 11
Roy, N., Imran, S. M., Siddiky, A., Sultana, S., Mahmud, S., Rashid, R., ALmerab, M. M., & Mamun, M. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321097 · Cited by 9
Prolonged parent-child separation and pain in adolescence: The role of HPA-axis genetic variations
Chen, X., Xu, L., Zeng, C., Zhang, X.-Y., Tao, F., & Sun, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.092 · Cited by 6
Goltser‐Dubner, T., Benarroch, F., Lavon, M., Amer, R., Canetti, L., Giesser, R., Kianski, E., Martin, J., Pevzner, D., Weinberg, P. B., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02923-3 · Cited by 6
Early-Life Adversity and Suicide Risk: The Role of Epigenetics
Turecki, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-47976-7_4 · Cited by 6
Dewell, S., Slater, D. M., Benzies, K., McDonald, S., & Tough, S. (2018) · SAGE Open Nursing · doi:10.1177/2377960818765272 · Cited by 5
Influence of FKBP5 Variants and Childhood Trauma on Brain Volume in Non-clinical Individuals
Kwon, A., Kim, S., Jeon, H., Lee, H. S., & Lee, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.663052 · Cited by 5
Mengelkoch, S., Alley, J. C., Cole, S. W., & Slavich, G. M. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.024 · Cited by 5
Stress, Trauma, and Risk for Attempted and Completed Suicide
Wilcox, H. C., & FAWCETT, J. A. (2012) · Psychiatric Annals · doi:10.3928/00485713-20120217-04 · Cited by 5
Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
Park, C. I., Kim, H. W., Hwang, S. S., Kang, J. I., & Kim, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-98032-6 · Cited by 7
Glucocorticoid-Dependent Epigenetic Regulation of Fkbp5
Lee, R. S. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-24493-8_4 · Cited by 4
Cîmpianu, M. E., Onișan, E., Sărac, V. M., Sărac, I., Ganea, M., Gligor, O., Bâlici, Ș., Nicula, G. Z., Domșa, E. M., Cîmpianu, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168053 · Cited by 4
Covault, J., Armeli, S., & Tennen, H. A. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112756 · Cited by 3
The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models
Jupp, B., & Dalley, J. W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_3 · Cited by 3
Parlapani, E., Nassika, Z., Kyriazis, O., & Nimatoudis, I. (2019) · Springer eBooks · doi:10.1007/978-3-030-18323-3_9 · Cited by 3
Stress, Vulnerability, and Suicide
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.003 · Cited by 3
ACE and its implication over the lifespan
Rokach, A., & Clayton, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85853-3.00008-2 · Cited by 2
Zhao, X., Wang, D., Chang, M., He, Z. J., Zeng, Z., Ren, M., Hu, Y., & Li, Z. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.03.138 · Cited by 2
Gene-Environment Interaction Studies in Suicidal Behaviour
Mandelli, L., & Serretti, A. (2015) · Advances in biological psychiatry · doi:10.1159/000434737 · Cited by 2
Epigenetic Biomarkers for Early-Life Adversity
Turecki, G. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-29901-3_7 · Cited by 2
Kalkman, H. O. (2021) · Psychiatry International · doi:10.3390/psychiatryint2010008 · Cited by 2
Han, J., Zhu, Y., Pan, D., Xue, H., Wang, S., Peng, Y., Liu, H., He, Y., & Yao, X. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.07.015 · Cited by 4
The epigenetics of suicide: The critical impact of environment on epigenetic regulation in suicide
Lutz, P.-É., Turecki, G., & Labonté, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00010-6 · Cited by 2
Gene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2016) · Springer eBooks · doi:10.1007/978-981-4560-53-5_41-2 · Cited by 2
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Hishimoto, A., Sasada, T., Fukutake, M., Shiroiwa, K., Supriyanto, I., & Shirakawa, O. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)73320-x · Cited by 2
Exploring the role of social workers in suicide prevention
Slater, T. (2014) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 2
Baharikhoob, P., Maslej, M. M., Wong, A. H. C., Mulsant, B. H., Blumberger, D. M., Courtney, D., Husain, M. I., Kurdyak, P. A., Kleinman, R. A., Torfason, A., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087561 · Cited by 1
Trilla, I. (2014) · Cited by 1
Engaging Trauma Survivors in Treatment
Snipes, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-49206-3_13 · Cited by 1
Labonté, B., Lutz, P.-É., & Turecki, G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00015-2 · Cited by 1
Labonté, B., Lutz, P.-É., & Turecki, G. (2014) · Academic Press eBooks · Cited by 1
Hall, R. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.122317 · Cited by 1
Suicidal behaviour: genes, environmental stress and temperamental traits
Mandelli, L., Carli, V., Serretti, A., & Sarchiapone, M. (2015) · Suicidologi/Nytt i suicidologi · doi:10.5617/suicidologi.2137 · Cited by 1
Behavioral Medical Epigenetics
Cox, O., & Lee, R. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00008-9 · Cited by 3
Gene-Environment Interactions and Role of Epigenetics in Depression
Lin, E., & Tsai, S. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_3 · Cited by 1
Wietfeldt, N. (2020) · International Journal of Medical Students · doi:10.5195/ijms.2020.437 · Cited by 1
Biological theories of suicidal behaviour
Turecki, G. (2021) · doi:10.1093/med/9780198834441.003.0022 · Cited by 1
Gene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_41-1 · Cited by 1
Hegerl, U., & Rujescu, D. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_92-1 · Cited by 2
Epigenetic Epidemiology of Psychiatric Disorders
Uddin, M., Bustamante, A. C., & Toyokawa, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00006-1
Richmond, C. (2015) · JMU Scholoraly Commons (James Madison University)
of childhood trauma FKBP5 as a possible moderator of the psychosis-inducing effects
Simons, C. J. P., Delespaul, P., Marcelis, M. C., van Os, J., van Winkel, R., Collip, D., Myin‐Germeys, I., Wichers, M., Jacobs, N., Derom, C. A., et al. (2013)
Würzburg, J.-M.-U., & Jakob, S. B. (2012)
Alcohol Consumption: A Study of Genetic and Environmental Correlates with Focus on the Stress System
Todkar, A. (2016) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Rozanov, V. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805199-3.00005-1
Thibodeau, E. L. (2016) · University of Minnesota Digital Conservancy (University of Minnesota)
Aspekte der Genetik, Epigenetik und Gen-Umwelt-Interaktion bei suizidalem Verhalten
Giegling, I., & Rujescu, D. (2017) · Nervenheilkunde · doi:10.1055/s-0038-1627008
Integrating behavior, hormones and genes associated with the primate HPA-axis
Gutleb, D. R. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7382
What Is Suicidal Behavior, and Can It Be Prevented?
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.002
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.008
I Predict, Therefore I Cannot Be
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.009
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.010
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.004
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.011
Neurodevelopmental Aspects of Suicide
Chatzittofis, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-68932-2_1
PSIHIČKI SIMPTOMI I KVALITETA ŽIVOTA STUDENATA IZ OBITELJI S ISKUSTVOM RATA
Babić, I., Babić, D., Martinac, M., Vasilj, I., & Vasilj, M. (2016) · Zdravstveni glasnik · doi:10.47960/2303-8616.2016.4.27
Using Student Voice to Identify Promising Practices in Social Emotional Learning
Ward-Roncalli, S. (2021) · doi:10.5642/cguetd/231
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.007
I Think, Therefore I Do Not Want to Be
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.006
Owalla, T. J., Ssebajjwe, W. J., Muhanguzi, D., Womersley, J. S., Kinyanda, E., & Kalungi, A. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.666426
(2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.013
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.015
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.001
Klengel, T., & Rein, T. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-29901-3_1
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.005
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.012
Gene-Environment Interactions, Stress, and Depression
Cohen‐Woods, S., & Harkess, K. N. (2016) · Springer eBooks · doi:10.1007/978-981-287-206-7_41
Hegerl, U., & Rujescu, D. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_92
Behavioral medical epigenetics
Cox, O., & Lee, R. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823928-5.00017-7
Tytell, M., & Robinson, M. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732249388.793545292
van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.014
Çocukluk Çağı Travmaları ile Acının Dönüştürücü Gücü Arasındaki İlişki
Kaptanoğlu, G., & Öksüz, Y. (2025) · Abant İzzet Baysal Üniversitesi Eğitim Fakültesi Dergisi · doi:10.17240/aibuefd.2025..-1567750
Sanabrais‐Jiménez, M. A., Elguea-Ortiz, Z. C., Morales-Cedillo, I. P., Pavón, J. J., Rosel-Vales, M., Saracco-Álvarez, R. A., & Camarena, B. (2025) · Brain Sciences · doi:10.3390/brainsci15111224
Coulon, S. M. (2014) · Scholar Commons (University of South Carolina)
Glucocorticoid mechanisms of neonatal separation effects on adult learning and memory
Wilber, A. A. (2010) · IUScholarWorks (Indiana University)
Sokolov, A. V., Manu, D.-M., Nordberg, D. O. T., Boström, A. D. E., Jokinen, J., & Schiöth, H. B. (2023) · Figshare · doi:10.6084/m9.figshare.22609666
Sokolov, A. V., Manu, D.-M., Nordberg, D. O. T., Boström, A. D. E., Jokinen, J., & Schiöth, H. B. (2023) · Figshare · doi:10.6084/m9.figshare.22609663
Metadata
- Authors
- Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M.-A.
- Affiliations
- VA New Jersey Health Care System (US)
- National Institutes of Health (US)
- Corresponding author
- Roy, Alec
- Venue
- Neuropsychopharmacology
- Published
- 2010-01-20
- Volume
- 35
- Issue
- 8
- Pages
- 1674-1683
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2962602
- OpenAlex
- W2043313558
- Cited by
- 282
- References
- 73
- Citations by year
- 2025: 8 · 2024: 1 · 2023: 12 · 2022: 7 · 2021: 22 · 2020: 15 · 2019: 17 · 2018: 34 · 2017: 18 · 2016: 28 · 2015: 30 · 2014: 26 · 2013: 21 · 2012: 18
- FWCI
- 22.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (Z99‐AA999999)
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000301, ZIAAA000306)
- National Institute on Drug Abuse (R01DA010336)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- FKBP5, childhood trauma, suicide attempts, gene-environment interaction, HPA axis dysregulation, single nucleotide polymorphisms, haplotypes, substance dependence, African Americans, stress-related genes
- MeSH terms
- Tacrolimus Binding Protein 5, Adult, Black or African American, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, New Jersey, Surveys and Questionnaires, Risk Factors, Suicide, Attempted, Linkage Disequilibrium, Computational Biology, Substance-Related Disorders, Polymorphism, Single Nucleotide, Tacrolimus Binding Proteins, Adult Survivors of Child Abuse, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
