FKBP5 polymorphisms modify the effects of childhood trauma
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FKBP5 single nucleotide polymorphisms interact with early trauma to predict both PTSD and major depression.
“FKBP5 single nucleotide polymorphisms have additionally been shown to interact with early trauma to predict both PTSD and major depression (36,37), possibly through involvement of allelespecific, environmentally dependent changes in methylation of specific cytosine-phosphate-guanine (CpG) sites (38).”
From Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation (2016) · cites this paper as [37]
The main text reports that FKBP5 SNP rs9470080 interacted with childhood adversity to predict PTSD risk in African-American participants; the interaction was not significant in European Americans. It does not report an FKBP5–early-trauma interaction predicting major depression. The depression study listed in the References concerns CRHR1, not FKBP5. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFKBP51 gene variants are associated with antidepressant response, depression disease status, suicide, personality traits, recovery from psychosocial stress, peritraumatic dissociation, PTSD, and modify effects of early life trauma in PTSD and major depression.
“This study was the first to identify a correlation of FKBP51 gene variants with response to antidepressant treatment, and also with the reactivity of the HPA axis in the dexamethasone (DEX)-CRH test.”
From FKBP51 and FKBP52 in signaling and disease (2011) · cites this paper as [74]
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of childhood trauma FKBP5 as a possible moderator of the psychosis-inducing effects
Simons, C. J. P., Delespaul, P., Marcelis, M. C., van Os, J., van Winkel, R., Collip, D., Myin‐Germeys, I., Wichers, M., Jacobs, N., Derom, C. A., et al. (2013)
Trotta, A. (2016) · Research Portal (King's College London)
- Authors
- Koenen, K. C., & Uddin, M.
- Affiliations
- Harvard University (US)
- University of Michigan (US)
- Corresponding author
- Koenen, Karestan C
- Venue
- Neuropsychopharmacology
- Published
- 2010-06-15
- Volume
- 35
- Issue
- 8
- Pages
- 1623-1624
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055470
- OpenAlex
- W2029398029
- Cited by
- 33
- References
- 11
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 10 · 2012: 2
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH078928, RC1MH088283, MH-078928, MH088283, MH07627)
- National Institute on Drug Abuse (DA 022720, R01DA022720, DA 022720-S1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- FKBP5, childhood trauma, gene-environment interaction, hypothalamic-pituitary-adrenal axis, genetic polymorphism, stress response, epigenetics
- MeSH terms
- Tacrolimus Binding Protein 5, Animals, Humans, Polymorphism, Single Nucleotide, Tacrolimus Binding Proteins, Adult Survivors of Child Abuse
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