D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

Neurocircuitry of Addiction

Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works

Basal ganglia

Alexander, G. E. (1998) · Cited by 891 · see citing works

Role of Distinct NMDA Receptor Subtypes at Central Synapses

Cull-Candy, S. G., & Leszkiewicz, D. N. (2004) · Science s STKE · doi:10.1126/stke.2552004re16 · Cited by 796 · see citing works

Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

Chatterton, J. E., Awobuluyi, M., Premkumar, L. S., Takahashi, H., Talantova, M. V., Shin, Y., Cui, J., Tu, S., Sevarino, K. A., Nakanishi, N., et al. (2002) · Nature · doi:10.1038/nature715 · Cited by 695 · see citing works

Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior

Spanagel, R. (2009) · Physiological Reviews · doi:10.1152/physrev.00013.2008 · Cited by 636 · see citing works

Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A

Das, S., Sasaki, Y., Rothe, T., Premkumar, L. S., Takasu, M. A., Crandall, J. E., Dikkes, P., Conner, D. A., Posina, V. R., Cheung, W., et al. (1998) · Nature · doi:10.1038/30748 · Cited by 611 · see citing works

Intermittent Access to 20% Ethanol Induces High Ethanol Consumption in Long–Evans and Wistar Rats

Simms, J. A., Steensland, P., Medina, B., Abernathy, K., Chandler, L. J., Wise, R. A., & Bartlett, S. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00753.x · Cited by 610 · see citing works

Glutamatergic substrates of drug addiction and alcoholism

Gass, J. T., & Olive, M. F. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.039 · Cited by 485 · see citing works

Nucleus Accumbens Neurons Are Innately Tuned for Rewarding and Aversive Taste Stimuli, Encode Their Predictors, and Are Linked to Motor Output

Roitman, M. F., Wheeler, R. A., & Carelli, R. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.055 · Cited by 453 · see citing works

A cognitive processing model of alcohol craving and compulsive alcohol use

Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.3.x · Cited by 356 · see citing works

The insula: a critical neural substrate for craving and drug seeking under conflict and risk

Naqvi, N. H., Gaznick, N., Tranel, D., & Bechara, A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12415 · Cited by 336 · see citing works

Functional Comparison of d ‐Serine and Glycine in Rodents: The Effect on Cloned NMDA Receptors and the Extracellular Concentration

Matsui, T., Sekiguchi, M., Hashimoto, A., Tomita, U., Nishikawa, T., & Wada, K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010454.x · Cited by 334 · see citing works

N-methyl-d-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability

Krystal, J. H., Petrakis, I. L., Mason, G. F., Trevisan, L. A., & D’Souza, D. C. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00054-8 · Cited by 313 · see citing works

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

Seif, T., Chang, S., Simms, J. A., Gibb, S. L., Dadgar, J., Chen, B. T., Harvey, B. K., Dorit Ron, A., Messing, R. O., Bonci, A., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3445 · Cited by 310 · see citing works

The Role of Memantine in the Treatment of Psychiatric Disorders Other Than the Dementias: A Review of Current Preclinical and Clinical Evidence

Sani, G., Serra, G., Kotzalidis, G. D., Romano, S., Tamorri, S. M., Manfredi, G., Caloro, M., Telesforo, C. L., Caltagirone, S. S., Panaccione, I., et al. (2012) · CNS Drugs · doi:10.2165/11634390-000000000-00000 · Cited by 273 · see citing works

Strategies to Enhance N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Schizophrenia, a Critical Review and Meta-Analysis

Tsai, G. E., & Lin, P. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361452 · Cited by 269 · see citing works

A cognitive processing model of alcohol craving and compulsive alcohol use

Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1080/09652140050111717 · Cited by 261 · see citing works

High dose D-serine in the treatment of schizophrenia

Kantrowitz, J. T., Malhotra, A. K., Cornblatt, B. A., Silipo, G. S., Balla, A., Suckow, R. F., D’Souza, C., Saksa, J. R., Woods, S. W., & Javitt, D. C. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.012 · Cited by 253 · see citing works

N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives

Millan, M. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2199-1 · Cited by 226 · see citing works

Obsessive–compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale

Anton, R. F. (2000) · Addiction · doi:10.1080/09652140050111771 · Cited by 185 · see citing works

Motivation for Alcohol Becomes Resistant to Quinine Adulteration After 3 to 4 Months of Intermittent Alcohol Self‐Administration

Hopf, F. W., Chang, S., Sparta, D. R., Bowers, M. S., & Bonci, A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01241.x · Cited by 183 · see citing works

Rodent models for compulsive alcohol intake

Hopf, F. W., & Lesscher, H. M. B. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.03.001 · Cited by 173 · see citing works

Obsessive–compulsive aspects of craving: development of the Obsessive Compulsive Drinking Scale

Anton, R. F. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.9.x · Cited by 170 · see citing works

Analysis of free d-serine in mammals and its biological relevance

Nishikawa, T. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.08.030 · Cited by 145 · see citing works

Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor.

Henderson, G., Johnson, J. W., & Ascher, P. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018288 · Cited by 141 · see citing works

Acamprosate Produces Its Anti-Relapse Effects Via Calcium

Spanagel, R., Vengeliene, V., Jandeleit, B., Fischer, W.-N., Grindstaff, K. K., Zhang, X., Gallop, M. A., Krstew, E., Lawrence, A. J., & Kiefer, F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.264 · Cited by 141 · see citing works

Modulation of the extinction of two different fear-motivated tasks in three distinct brain areas

Fiorenza, N. G., Rosa, J., Izquierdo, I., & Myskiw, J. D. C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.015 · Cited by 129 · see citing works

Obsessive and Compulsive Characteristics of Alcohol Abuse and Dependence: Quantification by a Newly Developed Questionnaire

Modell, J. G., Glaser, F. B., Mountz, J. M., Schmaltz, S. P., & Cyr, L. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01374.x · Cited by 122 · see citing works

Double-Blind, Randomized Comparison of Memantine and Escitalopram for the Treatment of Major Depressive Disorder Comorbid With Alcohol Dependence

Muhonen, L. H., Lönnqvist, J. K., Juva, K., & Alho, H. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0308 · Cited by 118 · see citing works

Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients

Krupitsky, E. M., Neznanova, O., Masalov, D. V., Burakov, A. M., Didenko, T., Romanova, T. N., Tsoy, M., Bespalov, A., Slavina, T. Y., Grinenko, A. Y., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.519 · Cited by 116 · see citing works

Excessive alcohol consumption is blocked by glial cell line–derived neurotrophic factor

Carnicella, S., Amamoto, R., & Dorit Ron, A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.12.001 · Cited by 114 · see citing works

Cell-type specific mechanisms of D-serine uptake and release in the brain

Martineau, M., Parpura, V., & Mothet, J. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00012 · Cited by 108 · see citing works

Bell-Shaped D-Serine Actions on Hippocampal Long-Term Depression and Spatial Memory Retrieval

Zhang, Z., Gong, N., Wang, W., Xu, L., & Xu, T. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn008 · Cited by 104 · see citing works

RESEARCH FOCUS ON COMPULSIVE BEHAVIOUR IN ANIMALS: Compulsive alcohol drinking in rodents

Vengeliene, V., Célèrier, E., Chaskiel, L., Penzo, F., & Spanagel, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00177.x · Cited by 103 · see citing works

Pharmacological Characterization of Glycine-Activated Currents in HEK 293 Cells Expressing N-Methyl-D-aspartate NR1 and NR3 Subunits

Smothers, C. T., & Woodward, J. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123836 · Cited by 102 · see citing works

A Pilot Double‐Blind Treatment Trial of Memantine for Alcohol Dependence

Evans, S. M., LEVIN, F. R., Brooks, D. J., & Garawi, F. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00360.x · Cited by 101 · see citing works

d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens

Torregrossa, M. M., Sanchez, H., & Taylor, J. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2523-10.2010 · Cited by 100 · see citing works

Inflexible and Indifferent Alcohol Drinking in Male Mice

Lesscher, H. M. B., van Kerkhof, L. W. M., & Vanderschuren, L. J. M. J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01199.x · Cited by 95 · see citing works

D‐cycloserine improves functional recovery and reinstates long‐term potentiation (LTP) in a mouse model of closed head injury

Yaka, R., Biegon, A. R., Grigoriadis, N., Simeonidou, C., Grigoriadis, S., Alexandrovich, A. G., Matzner, H., Schumann, J., Trembovler, V., Tsenter, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7856com · Cited by 93 · see citing works

Basal Ganglia

Gerfen, C. R. (2004) · The Rat Nervous System · doi:10.1016/b978-012547638-6/50019-5 · Cited by 85 · see citing works

Age‐related effects of the neuromodulator d‐serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat

Junjaud, G., Rouaud, E., Turpin, F., Mothet, J., & Billard, J.-M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03944.x · Cited by 82 · see citing works

Acute effects of memantine in combination with alcohol in moderate drinkers

Bisaga, A. M., & Evans, S. M. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1617-5 · Cited by 82 · see citing works

Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control

Deroche‐Gamonet, V., & Piazza, P. V. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.014 · Cited by 79 · see citing works

Reduced d-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity

Curcio, L., Podda, M. V., Leone, L., Piacentini, R., Mastrodonato, A., Cappelletti, P., Sacchi, S., Pollegioni, L., Grassi, C., & D’Ascenzo, M. (2013) · Brain · doi:10.1093/brain/awt036 · Cited by 79 · see citing works

Animal models of addiction: models for therapeutic strategies?

Wolffgramm, J., Galli, G., Heyne, A., & Thimm, F. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070067 · Cited by 78 · see citing works

Feasibility, Safety, and Efficacy of the Combination of D-Serine and Computerized Cognitive Retraining in Schizophrenia: An International Collaborative Pilot Study

D’Souza, D. C., Radhakrishnan, R., Perry, E. B., Bhakta, S. G., Singh, N. M., Yadav, R., Abi‐Saab, D., Pittman, B. P., Chaturvedi, S. K., Sharma, M. P., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.208 · Cited by 77 · see citing works

Why is D-serine nephrotoxic and α-aminoisobutyric acid protective?

Krug, A., Völker, K., Dantzler, W., & Silbernagl, S. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00441.2006 · Cited by 67 · see citing works

D ‐Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices

Rouaud, E., & Billard, J. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705541 · Cited by 65 · see citing works

Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats

Schwienbacher, I., Fendt, M., Richardson, R., & Schnitzler, H. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.037 · Cited by 59 · see citing works

Effect of systemic administration of d-serine on the levels of d- and l-serine in several brain areas and periphery of rat

Hashimoto, A., & Chiba, Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.05.036 · Cited by 51 · see citing works

Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence

Krystal, J. H., Petrakis, I. L., Limoncelli, D., Krasnicki, S., Trevisan, L. A., Pittman, B. P., & D’Souza, D. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.203 · Cited by 33 · see citing works

Interference with cellular differentiation by D ‐serine through antagonism at N‐methyl‐ D ‐aspartate receptors composed of NR1 and NR3A subunits in chondrocytes

Takarada, T., Takahata, Y., Takarada‐Iemata, M., Hinoi, E., Uno, K., Hirai, T., Yamamoto, T. M., & Yoneda, Y. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21821 · Cited by 33 · see citing works

Glycine site agonists of the N‐methyl‐ d ‐aspartate receptor and Parkinson's disease: A hypothesis

Heresco‐Levy, U., Shoham, S., & Javitt, D. C. (2013) · Movement Disorders · doi:10.1002/mds.25306 · Cited by 33 · see citing works

Excitatory amino acid‐induced excitation of dopamine‐containing neurons in the rat substantia nigra: Modulation by kynurenic acid

Wu, H., Schwarcz, R. M., & Shepard, P. D. (1994) · Synapse · doi:10.1002/syn.890160307 · Cited by 31 · see citing works

Differences in the Consumption of Ethanol and Flavored Solutions in Three Strains of Rats

Goodwin, F. L. W., Bergeron, N., & Amit, Z. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00222-1 · Cited by 30 · see citing works

Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens

Kretschmer, B., & Schmidt, W. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01561.1996 · Cited by 29 · see citing works

d ‐Cycloserine Blocks the Effects of Ethanol and HA‐966 in Rats Tested in the Elevated Plus‐Maze

Ferreira, V. M. M., & Morato, G. S. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04501.x · Cited by 28 · see citing works

Measuring the effect of glutamate receptor agonists on extracellular D-serine concentrations in the rat striatum using online microdialysis-capillary electrophoresis.

Ciriacks, C. M., & Bowser, M. T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.080 · Cited by 28 · see citing works

The role of D-serine as co-agonist of NMDA receptors in the nucleus accumbens: relevance to cocaine addiction

Dâ€TMAscenzo, M., Podda, M. V., & Grassi, C. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00016 · Cited by 24 · see citing works

Osteoclastogenesis is negatively regulated by D ‐serine produced by osteoblasts

Takarada, T., Takarada‐Iemata, M., Takahata, Y., Yamada, D., Yamamoto, T. M., Nakamura, Y., Hinoi, E., & Yoneda, Y. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24048 · Cited by 19 · see citing works

Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist d-serine

Lockridge, A. D., Romero, G. E., Harrington, J., Newland, B., Gong, Z., Cameron, A., & Yuan, L. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.11.004 · Cited by 13 · see citing works

Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co‐Agonist Site

DeBrouse, L., Hurd, B., Kiselycznyk, C., Plitt, A. R., Todaro, A., Mishina, M., Grant, S. G. N., Camp, M., Gunduz‐Cinar, O., & Holmes, A. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01922.x · Cited by 11 · see citing works

Thermoregulatory deficits following prenatal alcohol exposure: Structural correlates

Zimmerberg, B. (1989) · Alcohol · doi:10.1016/0741-8329(89)90009-8 · Cited by 9 · see citing works

Astrocyte function from information processing to cognition and cognitive impairment

Santello, M., Toni, N., & Volterra, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0325-8 · Cited by 737 · see citing works

Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis

Kim, R., Healey, K. L., Sepulveda-Orengo, M. T., & Reissner, K. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.002 · Cited by 141 · see citing works

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

Radke, A. K., Sneddon, E. A., Frasier, R. M., & Hopf, F. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073788 · Cited by 88 · see citing works

Increased Responding for Alcohol and Resistance to Aversion in Female Mice

Sneddon, E. A., Ramsey, O. R., Thomas, A.-M., & Radke, A. K. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14384 · Cited by 85 · see citing works

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

Zheng, H.-F., Wang, W.-Q., Li, X., Rauw, G. A., & Baker, G. B. (2016) · Amino Acids · doi:10.1007/s00726-016-2332-y · Cited by 82 · see citing works

Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers

Grodin, E. N., Sussman, L., Sundby, K. K., Brennan, G. M., Diazgranados, N., Heilig, M. A., & Momenan, R. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.06.009 · Cited by 75 · see citing works

Chronic EtOH effects on putative measures of compulsive behavior in mice

Radke, A. K., Jury, N. J., Kocharian, A., Marcinkiewcz, C. A., Lowery‐Gionta, E. G., Pleil, K. E., McElligott, Z. A., McKlveen, J. M., Kash, T. L., & Holmes, A. (2015) · Addiction Biology · doi:10.1111/adb.12342 · Cited by 75 · see citing works

Advances in D-Amino Acids in Neurological Research

Seckler, J. M., & Lewis, S. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197325 · Cited by 68 · see citing works

d-Amino acids: new clinical pathways for brain diseases

Souza, I. N. D. O., Roychaudhuri, R., de Belleroche, J., & Mothet, J. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.09.001 · Cited by 68 · see citing works

I nhibition of astroglial connexin43 hemichannels with TAT ‐ G ap19 exerts anticonvulsant effects in rodents

Walrave, L., Pierre, A., Albertini, G., Aourz, N., Bundel, D. D., Eeckhaut, A. V., Vinken, M., Giaume, C., Leybaert, L., & Smolders, I. J. (2018) · Glia · doi:10.1002/glia.23341 · Cited by 66 · see citing works

Do specific NMDA receptor subunits act as gateways for addictive behaviors?

Hopf, F. W. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12348 · Cited by 63 · see citing works

Punishment models of addictive behavior

Vanderschuren, L. J. M. J., Minnaard, A. M., Smeets, J. A. S., & Lesscher, H. M. B. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.10.007 · Cited by 60 · see citing works

Drinking despite adversity: behavioral evidence for a head down and push strategy of conflict‐resistant alcohol drinking in rats

Darevsky, D. M., Gill, T. M., Vitale, K. R., Hu, B., Wegner, S. A., & Hopf, F. W. (2018) · Addiction Biology · doi:10.1111/adb.12608 · Cited by 58 · see citing works

Additive influences of acute early life stress and sex on vulnerability for aversion‐resistant alcohol drinking

Radke, A. K., Held, I. T., Sneddon, E. A., Riddle, C. A., & Quinn, J. J. (2019) · Addiction Biology · doi:10.1111/adb.12829 · Cited by 59 · see citing works

Recent perspectives on orexin/hypocretin promotion of addiction-related behaviors

Hopf, F. W. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108013 · Cited by 60 · see citing works

Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure

Kimbrough, A., Kim, S., Cole, M., Brennan, M., & George, O. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13434 · Cited by 54 · see citing works

Neurobiology of alcohol seeking behavior

Domi, E., Domi, A., Adermark, L., Heilig, M. A., & Augier, E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15343 · Cited by 53 · see citing works

Advances in behavioral animal models of alcohol use disorder

Goltseker, K., Hopf, F. W., & Barak, S. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.05.014 · Cited by 49 · see citing works

The role of anterior insula–brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking

Sergio, T. D. O., Lei, K., Kwok, C., Ghotra, S., Wegner, S. A., Walsh, M. M., Waal, J., Darevsky, D. M., & Hopf, F. W. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01071-w · Cited by 44 · see citing works

Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Lei, K., Wegner, S. A., Yu, J. H., Mototake, A., Hu, B., & Hopf, F. W. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00400 · Cited by 43 · see citing works

Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function

Joffe, M. E., & Grueter, B. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.002 · Cited by 41 · see citing works

Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice

Lei, K., Wegner, S. A., Yu, J.-H., & Hopf, F. W. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.008 · Cited by 41 · see citing works

Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans

Xu, K., Montalvo‐Ortiz, J. L., Zhang, X., Southwick, S. M., Krystal, J. H., Pietrzak, R. H., & Gelernter, J. E. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14168 · Cited by 41 · see citing works

Advances in understanding meso‐cortico‐limbic‐striatal systems mediating risky reward seeking

Piantadosi, P. T., Halladay, L. R., Radke, A. K., & Holmes, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15342 · Cited by 37 · see citing works

Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals

Lei, K., Kwok, C., Darevsky, D. M., Wegner, S. A., Yu, J.-H., Nakayama, L., Pedrozo, V., Anderson, L., Ghotra, S., Fouad, M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00088 · Cited by 38 · see citing works

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E., Demmings, M. D., Fernandez, R., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 31 · see citing works

Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence

Nentwig, T. B., Starr, E. M., Chandler, L. J., & Glover, E. J. (2019) · Alcohol · doi:10.1016/j.alcohol.2019.01.006 · Cited by 36 · see citing works

Behavioral indicators of succeeding and failing under higher-challenge compulsion-like alcohol drinking in rat

Darevsky, D. M., & Hopf, F. W. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112768 · Cited by 32 · see citing works

Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies

Leggio, L., Falk, D. E., Ryan, M. L., Fertig, J. B., & Litten, R. Z. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_295 · Cited by 32 · see citing works

A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice

Lei, K., Wegner, S. A., Yu, J.-H., Simms, J. A., & Hopf, F. W. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.07.008 · Cited by 30 · see citing works

Advances in Pharmacotherapy Development: Human Clinical Studies

Litten, R. Z., Falk, D. E., Ryan, M. L., Fertig, J. B., & Leggio, L. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_79 · Cited by 29 · see citing works

Animal models of compulsion alcohol drinking: Why we love quinine-resistant intake and what we learned from it

Sergio, T. D. O., Frasier, R. M., & Hopf, F. W. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1116901 · Cited by 28 · see citing works

Cortical GluN2B deletion attenuates punished suppression of food reward-seeking

Radke, A. K., Nakazawa, K., & Holmes, A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4033-8 · Cited by 28 · see citing works

Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking

Linsenbardt, D. N., Timme, N. M., & Lapish, C. C. (2019) · eNeuro · doi:10.1523/eneuro.0489-18.2019 · Cited by 26 · see citing works

Loss of control over alcohol seeking in rats depends on individual vulnerability and duration of alcohol consumption experience

Spoelder, M., Pol, S., Janssen, B. S. G., Baars, A. M., Vanderschuren, L. J. M. J., & Lesscher, H. M. B. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000304 · Cited by 25 · see citing works

Do Alcohol-Related AMPA-Type Glutamate Receptor Adaptations Promote Intake?

Hopf, F. W., & Mangieri, R. A. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_105 · Cited by 23 · see citing works

The contribution of medium spiny neuron subtypes in the nucleus accumbens core to compulsive-like ethanol drinking

Sneddon, E. A., Schuh, K. M., Frankel, J. W., & Radke, A. K. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108497 · Cited by 23 · see citing works

Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption

de Carvalho, L. M., Chen, H., Sutter, M., & Lasek, A. W. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1122423 · Cited by 23 · see citing works

Differential importance of nucleus accumbens Ox1Rs and AMPARs for female and male mouse binge alcohol drinking

Kwok, C., Lei, K., Pedrozo, V., Anderson, L., Ghotra, S., Walsh, M. M., Li, L., Yu, J.-H., & Hopf, F. W. (2021) · Scientific Reports · doi:10.1038/s41598-020-79935-2 · Cited by 18 · see citing works

A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking

Wegner, S. A., Hu, B., Sergio, T. D. O., Darevsky, D. M., Kwok, C., Lei, K., & Hopf, F. W. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107681 · Cited by 19 · see citing works

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Irimia, C., Buczynski, M. W., Natividad, L. A., Laredo, S. A., Avalos, L. N., & Parsons, L. H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2466-16.2017 · Cited by 19 · see citing works

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity

Lockridge, A. D., Gustafson, E. C., Wong, A., Miller, R. F., & Alejandro, E. U. (2021) · Cells · doi:10.3390/cells10010093 · Cited by 18 · see citing works

Crossed High-Alcohol-Preferring Mice Exhibit Aversion-Resistant Responding for Alcohol with Quinine but not Foot Shock PunishmentPreprint

Sneddon, E. A., Schuh, K. M., Fennell, K. A., Grahame, N. J., & Radke, A. K. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4122362 · Cited by 18 · see citing works

VTA dopamine neuron plasticity – the unusual suspects

Xin, W., Edwards, N., & Bonci, A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13425 · Cited by 17 · see citing works

Orbitofrontal cortex subregion inhibition during binge-like and aversion-resistant alcohol drinking

Schuh, K. M., Sneddon, E. A., Nader, A. M., Muench, M. A., & Radke, A. K. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.11.004 · Cited by 15 · see citing works

Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit

Radke, A. K., Jury, N. J., Delpire, E. J., Nakazawa, K., & Holmes, A. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.07.005 · Cited by 15 · see citing works

Modeling Aversion Resistant Alcohol Intake in Indiana Alcohol-Preferring (P) Rats

Katner, S. N., Sentir, A. M., Steagall, K. B., Ding, Z., Wetherill, L. F., Hopf, F. W., & Engleman, E. A. (2022) · Brain Sciences · doi:10.3390/brainsci12081042 · Cited by 15 · see citing works

Optogenetic investigation of neural mechanisms for alcohol-use disorder

Juarez, B., Liu, Y., Zhang, L., & Han, M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.05.005 · Cited by 14 · see citing works

Genetic loss of GluN2B in D1-expressing cell types enhances long-term cocaine reward and potentiation of thalamo-accumbens synapses

Joffe, M. E., Turner, B. D., Delpire, E. J., & Grueter, B. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0131-8 · Cited by 11 · see citing works

Understanding sex differences and the translational value of models of persistent substance use despite negative consequences

Maddern, X. J., Walker, L. C., Anversa, R. G., Lawrence, A. J., & Campbell, E. J. (2024) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2024.107944 · Cited by 11 · see citing works

The role of beta- and alpha-adrenergic receptors on alcohol drinking

Sergio, T. D. O., Wean, S. E., Katner, S. N., & Hopf, F. W. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109545 · Cited by 10 · see citing works

Leveraging Neural Networks in Preclinical Alcohol Research

Smith, L. C., & Kimbrough, A. (2020) · Brain Sciences · doi:10.3390/brainsci10090578 · Cited by 8 · see citing works

Neural activity in anterior insula at drinking onset and licking relates to compulsion-like alcohol consumption

Starski, P. A., Morningstar, M. D., Katner, S. N., Frasier, R. M., Sergio, T. D. O., Wean, S. E., Lapish, C. C., & Hopf, F. W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1490-23.2023 · Cited by 8 · see citing works

Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge

Sergio, T. D. O., Darevsky, D. M., Kellner, J., Soares-Rachetti, V. D. P., Albino, M. D. C., Maulucci, D. P., Wean, S. E., & Hopf, F. W. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111008 · Cited by 8 · see citing works

The GLP-1 receptor agonist exendin-4 reduces taurine and glycine in nucleus accumbens of male rats, an effect tentatively involving the nucleus tractus solitarius

Edvardsson, C. E., Vestlund, J., Ericson, M., & Jerlhag, E. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1439203 · Cited by 7 · see citing works

Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking

Starski, P. A., Sergio, T. D. O., & Hopf, F. W. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100102 · Cited by 7 · see citing works

Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats

McDonald, A. J., Nemat, P., Hullenaar, T. V. ’., Schetters, D., van Mourik, Y., Alonso-Lozares, I., Vries, T. J. D., & Marchant, N. J. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01940-0 · Cited by 6 · see citing works

Long-Term Alcohol Drinking Reduces the Efficacy of Forced Abstinence and Conditioned Taste Aversion in Crossed High-Alcohol-Preferring Mice

O'Tousa, D. S., & Grahame, N. J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13115 · Cited by 5 · see citing works

Aversion-associated drug and alcohol seeking in females

Arnold, M. E., & Schank, J. R. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101095 · Cited by 6 · see citing works

Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats

Prados-Pardo, Á., Martín-González, E., Mora, S., Martín, C., Olmedo-Córdoba, M., Pérez-Fernández, C., Sánchez-Santed, F., & Moreno, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03506-5 · Cited by 6 · see citing works

NMDA Receptor Glycine Binding Site Modulators for Prevention and Treatment of Ketamine Use Disorder

Hsiao, Y.-C., Lee, M.-Y., Chan, M., & Chen, H. (2023) · Pharmaceuticals · doi:10.3390/ph16060812 · Cited by 5 · see citing works

Alcohol availability during withdrawal gates the impact of alcohol vapor exposure on responses to alcohol cues

Carpio, M. J., Gao, R., Wooner, E., Cayton, C. A., & Richard, J. M. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06192-8 · Cited by 4 · see citing works

D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease

Wang, J., Guo, Y., Han, W., Zhang, H., & Jiang, P. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01696-9 · Cited by 3 · see citing works

Neuroscience: Rewiring the brain

Bourzac, K. (2015) · Nature · doi:10.1038/522s50a · Cited by 3 · see citing works

Genetic Variability in Adenosine Deaminase‐Like Contributes to Variation in Alcohol Preference in Mice

Lesscher, H. M. B., Bailey, A., & Vanderschuren, L. J. M. J. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13409 · Cited by 3 · see citing works

Evidence for different greater-persistence strategies under lower and higher challenge for alcohol in female ratsPreprint

Sergio, T. D. O., Darevsky, D. M., Soares, V. D. P., Albino, M. D. C., Maulucci, D. P., Wean, S. E., & Hopf, F. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.18.492488 · Cited by 3 · see citing works

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumptionPreprint

Starski, P. A., Morningstar, M. D., Katner, S. N., Frasier, R. M., Sergio, T. D. O., Wean, S. E., Lapish, C. C., & Hopf, F. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.24.493243 · Cited by 3 · see citing works

Nucleus accumbens core chemogenetic excitation in male mice and chemogenetic inhibition in female mice reduced ethanol reward

Chan, A. E., Driscoll, G. S., Usmani, Z., & Ozburn, A. R. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00745-0 · Cited by 2 · see citing works

Detection and functional assessment of D-amino acids as potential biomarkers in neurological disorders

Talebi, M., Sharifi-Ardani, S. E., Ghannadzadeh, F. S., Sattarpour, M., Jahanseir, A., Hashemi, S., & Jahani, R. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11207-6 · Cited by 2 · see citing works

Lickometry to Circuitry: How Compulsion-Like Alcohol Drinking Microstructure Helped Discover Functional Differences in Salience Network Regions

Sergio, T. D. O., Starski, P. A., & Hopf, F. W. (2023) · Neuromethods · doi:10.1007/978-1-0716-3267-3_4 · Cited by 2 · see citing works

LOSS OF CONTROL OVER SUBSTANCE USE

Minnaard, A. M. (2020) · doi:10.33540/163 · Cited by 1 · see citing works

Sexually Dimorphic Role for Insular Perineuronal Nets in Aversion-Resistant Ethanol ConsumptionPreprint

de Carvalho, L. M., Chen, H., Sutter, M., & Lasek, A. W. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.27.525899 · Cited by 1 · see citing works

THE ROLE OF ALPHA- AND BETA-ADRENERGIC RECEPTORS ON COMPULSION-LIKE ALCOHOL DRINKINGPreprint

Sergio, T. D. O., Wean, S. E., Katner, S. N., & Hopf, F. W. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.20.517252

Impact of adolescent social Isolation on increased risk for alcohol intake and aversion-resistant drinking in males and femalesPreprint

Burke, A. R., Sullivan, M., Pereda, C., Reser, G., McIntosh, O., Arenas, S., Cunningham, N., Hopf, F. W., & Lukkes, J. L. (2026) · Research Square · doi:10.21203/rs.3.rs-9859563/v1

Basal forebrain projections to the lateral habenula regulate ethanol and sucrose consumptionPreprint

Kermoade, K., Hulet, E., Paulson, A., Woods, P., Woldemariam, G., & Richard, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.02.736151

A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking

Wegner, S. A., Hu, B., Sergio, T. D. O., Darevsky, D. M., Kwok, C., Lei, K., & Hopf, F. W. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107681 · Cited by 19 · see citing works

PHARMACOLOGY AND CELL METABOLISM D-Cycloserine Facilitates Extinction of Conditioned Alcohol-Seeking Behaviour in Rats

Vengeliene, V., & Spanagel, R. (2013)

d-Cycloserine Facilitates Extinction of Conditioned Alcohol-Seeking Behaviour in Rats

Vengeliene, V., Kiefer, F., & Spanagel, R. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn067 · Cited by 57 · see citing works

Effects of d-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial

Kiefer, F., Kirsch, M., Bach, P., Hoffmann, S., Reinhard, I., Jorde, A., von der Goltz, C., Spanagel, R., Mann, K. F., Loeber, S., et al. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3882-5 · Cited by 66 · see citing works

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

Seif, T., Chang, S., Simms, J. A., Gibb, S. L., Dadgar, J., Chen, B. T., Harvey, B. K., Dorit Ron, A., Messing, R. O., Bonci, A., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3445 · Cited by 310 · see citing works