The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Pathological Overeating: Emerging Evidence for a Compulsivity Construct
Open accessAbstract
Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical and psychiatric conditions such as forms of obesity and eating disorders. Although feeding research is moving toward a better understanding of the proposed addictive properties of food, the components and the mechanisms contributing to compulsive eating are not yet clearly defined or understood. Current understanding highlights three elements of compulsive behavior as it applies to pathological overeating: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive consequences. These elements emerge through mechanisms involving pathological habit formation through an aberrant learning process, the emergence of a negative emotional state, and dysfunctions in behavioral control. Dysfunctions in systems within neurocircuitries that comprise the basal ganglia, the extended amygdala, and the prefrontal cortex result in compulsive eating behaviors. Here, we present evidence to relate compulsive eating behavior and addiction and to characterize their underlying neurobiological mechanisms. A major need to improve understanding of compulsive eating through the integration of complex motivational, emotional, and cognitive constructs is warranted.
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“Note that a similar theoretical framework has been proposed for compulsive eating, in which habitual overeating, overeating to relieve a negative emotional state, and overeating despite aversive consequences reflect the three functional domains that are outlined in drug addiction (Moore et al., 2017(Moore et al., , 2019)).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Moore et al., 2017
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Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Self-citationInterventions and Manipulations of Interoception
Weng, H. Y., Feldman, J. L., Leggio, L., Napadow, V., Park, J., & Price, C. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.010 · Cited by 250
Chuong, V., Farokhnia, M., Khom, S., Pince, C. L., Elvig, S. K., Vlkolinsky, R., Marchette, R. C. N., Koob, G. F., Roberto, M., Vendruscolo, L. F., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.170671 · Cited by 214
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Bulik, C. M., Coleman, J. R. I., Hardaway, J. A., Breithaupt, L. E., Watson, H. J., Bryant, C. D., & Breen, G. D. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01071-z · Cited by 196
Latent traits of impulsivity and compulsivity: toward dimensional psychiatry
Chamberlain, S. R., Štochl, J., Redden, S. A., & Grant, J. E. (2017) · Psychological Medicine · doi:10.1017/s0033291717002185 · Cited by 108
Metadata
- Authors
- Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P.
- Affiliations
- Boston University (US)
- National Institutes of Health (US)
- Corresponding author
- Cottone, Pietro
- Venue
- Neuropsychopharmacology
- Published
- 2016-12-06
- Volume
- 42
- Issue
- 7
- Pages
- 1375-1389
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5436113
- OpenAlex
- W2560447148
- Cited by
- 126
- References
- 218
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 5 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 8 · 2017: 9
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- National Institute on Alcohol Abuse and Alcoholism (AA024439)
- National Institute of Mental Health (MH091945, DA030425, MH093650)
- National Institute on Drug Abuse (DA030425)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- compulsive eating, compulsivity, food addiction, transdiagnostic constructs, emotional overeating, aversive consequences, habit formation, basal ganglia, extended amygdala, prefrontal cortex, obesity, eating disorders
- MeSH terms
- Amygdala, Compulsive Behavior, Humans, Hyperphagia, Nerve Net, Behavior, Addictive, Prefrontal Cortex
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