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Pathological Overeating: Emerging Evidence for a Compulsivity Construct
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Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical and psychiatric conditions such as forms of obesity and eating disorders. Although feeding research is moving toward a better understanding of the proposed addictive properties of food, the components and the mechanisms contributing to compulsive eating are not yet clearly defined or understood. Current understanding highlights three elements of compulsive behavior as it applies to pathological overeating: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive consequences. These elements emerge through mechanisms involving pathological habit formation through an aberrant learning process, the emergence of a negative emotional state, and dysfunctions in behavioral control. Dysfunctions in systems within neurocircuitries that comprise the basal ganglia, the extended amygdala, and the prefrontal cortex result in compulsive eating behaviors. Here, we present evidence to relate compulsive eating behavior and addiction and to characterize their underlying neurobiological mechanisms. A major need to improve understanding of compulsive eating through the integration of complex motivational, emotional, and cognitive constructs is warranted.
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“Note that a similar theoretical framework has been proposed for compulsive eating, in which habitual overeating, overeating to relieve a negative emotional state, and overeating despite aversive consequences reflect the three functional domains that are outlined in drug addiction (Moore et al., 2017(Moore et al., , 2019)).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Moore et al., 2017
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Modeling and testing compulsive eating behaviors in animals
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Metadata
- Authors
- Moore, C. F., Sabino, V., Koob, G. F., & Cottone, P.
- Affiliations
- Boston University (US)
- National Institutes of Health (US)
- Corresponding author
- Cottone, Pietro
- Venue
- Neuropsychopharmacology
- Published
- 2016-12-06
- Volume
- 42
- Issue
- 7
- Pages
- 1375-1389
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5436113
- OpenAlex
- W2560447148
- Cited by
- 126
- References
- 218
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 5 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 16 · 2018: 8 · 2017: 9
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- National Institute on Alcohol Abuse and Alcoholism (AA024439)
- National Institute of Mental Health (MH091945, DA030425, MH093650)
- National Institute on Drug Abuse (DA030425)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- compulsive eating, compulsivity, food addiction, transdiagnostic constructs, emotional overeating, aversive consequences, habit formation, basal ganglia, extended amygdala, prefrontal cortex, obesity, eating disorders
- MeSH terms
- Amygdala, Compulsive Behavior, Humans, Hyperphagia, Nerve Net, Behavior, Addictive, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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