Differentiation of cardiomyocytes and generation of human engineered heart tissue

Breckwoldt, Kaja, Letuffe-Brenière, David, Mannhardt, Ingra, Schulze, Thomas, Ulmer, Bärbel, Werner, Tessa, Benzin, Anika, Klampe, Birgit +14 more·2017·Nature Protocols

Cited by (272)

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  8. Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
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  9. Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement
    Jessica A. Cooke, Andrew P. Voigt, Michael A. Collingwood, Nicholas E. Stone, S. Scott Whitmore, Adam P. DeLuca, Erin R. Burnight, Kristin R. Anfinson, Christopher A. Vakulskas, Austin J Reutzel et al. · 2023 · Stem Cells Translational Medicine
  10. Lysophosphatidic Acid Receptor 4 Is Transiently Expressed during Cardiac Differentiation and Critical for Repair of the Damaged Heart
    Jin Woo Lee, Choon-Soo Lee, Yong-Rim Ryu, Jaewon Lee, HyunJu Son, Hyun-Jai Cho, Hyo-Soo Kim · 2020 · Molecular Therapy
  11. Regulation of ICa,L and force by PDEs in human‐induced pluripotent stem cell‐derived cardiomyocytes
    Umber Saleem, Djemail Ismaili, Ingra Mannhardt, Hans Otto Pinnschmidt, Thomas Schulze, Torsten Christ, Thomas Eschenhagen, Arne Hansen · 2020 · British Journal of Pharmacology
  12. Applications of Cardiac Extracellular Matrix in Tissue Engineering and Regenerative Medicine
    Mark C. Daley, Spencer L. Fenn, Lauren Deems Black · 2018 · Advances in experimental medicine and biology
  13. Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells
    Yong Jin Kim, Amin Tamadon, Yoon Young Kim, Byeong-Cheol Kang, Seung‐Yup Ku · 2021 · International Journal of Molecular Sciences
  14. Toward Human Models of Cardiorenal Syndrome in vitro
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  15. Hydrogel‐Sheathed hiPSC‐Derived Heart Microtissue Enables Anchor‐Free Contractile Force Measurement
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  16. A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM
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  17. Mitochondrial DNA: Hotspot for Potential Gene Modifiers Regulating Hypertrophic Cardiomyopathy
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  18. Meticulous optimization of cardiomyocyte yields in a 3-stage continuous integrated agitation bioprocess
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  19. DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs
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  20. Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes
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  33. Comparative Proteomic Analysis Reveals the Upregulation of Ketogenesis in Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells
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  36. Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture
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  37. High-Throughput Phenotyping Toolkit for Characterizing Cellular Models of Hypertrophic Cardiomyopathy In Vitro
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  38. Cellular model systems to study cardiovascular injury from chemotherapy
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  39. An improved two-step method for extraction and purification of primary cardiomyocytes from neonatal mice
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  40. Integrating Hierarchical Vasculature into Engineered Cardiac Tissues
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  41. Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation
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  44. Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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  46. Human-Engineered Atrial Tissue for Studying Atrial Fibrillation
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  47. INDUCED PLURIPOTENT STEM CELLS FOR MODELLING ENERGETIC ALTERATIONS IN HYPERTROPHIC CARDIOMYOPATHY.
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  48. Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study
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  49. Wnt Modulation Enhances Otic Differentiation by Facilitating the Enucleation Process but Develops Unnecessary Cardiac Structures
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  50. Mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion
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  55. Regulation of basal and norepinephrine-induced cAMP and ICa in hiPSC-cardiomyocytes: Effects of culture conditions and comparison to adult human atrial cardiomyocytes
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  56. Multi-Omics Characterization of a Human Stem Cell-Based Model of Cardiac Hypertrophy
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