Differentiation of cardiomyocytes and generation of human engineered heart tissue

Cited by (272)

Items 201–272 of 272

  1. Highly sensitive hair springs to measure the contraction force of engineered cardiac tissues
    Qian‐Ru Xiao, Si Sun, Nihad Cheraga, Kaihong Wu, Yong Dong Jiang, Ning‐Ping Huang · 2020 · Materials Horizons
  2. Strategies for constructing pluripotent stem cell‐ and progenitor cell‐derived three‐dimensional cardiac micro‐tissues
    Xinyue Chu, Mingyu Wang, Xiaoyan Qiu, Yun Huang, Tong Li, Edward Otieno, Na Li, Li Luo, Xiong Xiao · 2021 · Journal of Biomedical Materials Research Part A
  3. Designing a Bioreactor to Improve Data Acquisition and Model the Throughput of Engineered Cardiac Tissues
    Camille Van Neste, Karlo A. Wiley, Serena W. Chang, Joseph A. Borrello, Irene C. Turnbull, Kevin D. Costa · 2023 · Journal of Visualized Experiments
  4. Directed Evolution of AAV9 for Efficient Gene Expression in Cardiomyocytes In Vitro and In Vivo
    Leonard Hüttermann, Lena C. Schröder, Prithviraj Manohar Vijaya Shetty, Timo Jonker, Susanne S. Hille, Anca Kliesow Remes, Andrea Matzen, Arnie Boender, Dirk Grimm, Derk Frank et al. · 2025 · Human Gene Therapy
  5. Altered endoplasmic reticulum calcium loading in human PLN-R14del cardiomyopathy
    Willem Borbein, Lukas Dahmlos, Umber Saleem, Marina C Reinsch, Ingke Braren, Thomas Schulze, Birgit Klampe, Friederike Cuello, Justus Stenzig, Thomas Eschenhagen A et al. · 2025 · Frontiers in Cell and Developmental Biology
  6. Combine the wet and dry ingredients: Mixing experimental and computational models for a deeper understanding of stem cell‐derived cardiomyocytes
    Janice Yang, Eric A. Sobie · 2025 · The Journal of Physiology
  7. Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures
    Christopher S. Dunham, Madelynn E. Mackenzie, Haruko Nakano, Alexis R. Kim, Michal B. Juda, Atsushi Nakano, Adam Z. Stieg, James Kazimierz Gimzewski · 2022 · PLoS ONE
  8. Human Induced Pluripotent Stem Cells as Platform for Functional Examination of Cardiovascular Genetics in a Dish
    Ralf J. Dirschinger, Tatjana Dorn, Alessandra Moretti · 2019 · Cardiac and vascular biology
  9. Analysing Genetic Programs of Cell Differentiation to Study Cardiac Cell Diversification
    Zhixuan Wu, Sophie Shen, Yuliangzi Sun, Tessa R. Werner, Stephen T. Bradford, Nathan J. Palpant · 2022 · Springer eBooks
  10. Efficient Protocols for Fabricating a Large Human Cardiac Muscle Patch from Human Induced Pluripotent Stem Cells
    Ling Gao, Jianyi Jay Zhang · 2020 · Methods in molecular biology
  11. Recombinant annexin A6 promotes membrane repair in a stem cell derived-cardiomyocyte model of dystrophic cardiomyopathy
    Dominic E. Fullenkamp, Alexander B. Willis, Jodi L Curtin, Ansel Philip Amaral, Sloane I. Harris, Paul W. Burridge, Alexis R. Demonbreun, Elizabeth M. McNally · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  12. A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM
    Carl Schulz, Muhammed Ikbal Sönmez, Julia Krause, Edzard Schwedhelm, Bangfen Pan, Dzenefa Alihodzic, Arne Hansen, Thomas Eschenhagen A, Torsten Christ · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor
    Maksymilian Prondzynski, Raul Hernandes Bortolin, Paul Berkson, Michael A. Trembley, Kevin Shani, Mason Sweat, Joshua Mayourian, Albert M. Cordoves, Nnaemeka J. Anyanwu, Yashasvi Tharani et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Metabolic cardiomyopathies: untangling clinical heterogeneity with human stem-cell derived models
    Adriana S Passadouro, Berith M. Balfoort, Mirjam Langeveld, Clara van Karnebeek, Jolanda van der Velden, Riekelt H. Houtkooper, Signe Mosegaard · 2025 · EMBO Molecular Medicine
  15. Investigating the Anticancer Effects of Sulforaphane in an In Vitro Coculture Model of Prostate Cancer Cells with Engineered Heart Tissue
    Jane In den Birken, Laura Rathjens, Hannah Münch, Tina Rohlfing, Κωνσταντίνα Σταθοπούλου, Alexandra Rhoden, Gunhild v. Amsberg, Thomas Eschenhagen A, Sergey A. Dyshlovoy, Friederike Cuello · 2025 · ACS Pharmacology & Translational Science
  16. Short-term electrical stimulation promotes partial functional and morphological maturation of human-induced pluripotent stem cell-derived cardiomyocytes enabling cardiotoxicity risk mitigation at early-stage drug discovery for cardiac contractility modulation
    Hayato Miyoshi, Kaoru Morimura, Reiko Hara, Ritsuko Hori, Eriko Watanabe, Nobuyuki Mochizuki, Ayako Kamei, Rika Yamazaki, Katsuyuki Kazusa · 2026 · Toxicological Sciences
  17. Biologics for cardiovascular diseases: from bench to bedside
    Xiaochi Sun, Xinmeng Wang, Ruikun Jia, Jie Tang, X Y Zeng, Fulei Zhao, Fanlian Zeng, Nongyu Huang, Jiong Li, Kaijun Cui · 2026 · Signal Transduction and Targeted Therapy
  18. Human iPSC-derived engineered heart tissue model of diastolic dysfunction in heart failure with preserved ejection fraction
    Hidenori Tani, Kotaro Haga, Taijun Moriwaki, Uikyu Bang, Shohei Fujii, Daichi SEKIGUCHI, Yuki Yamamoto, Kuniko Momoi, Masatoshi Ohno, M Nakamura et al. · 2026 · Cell stem cell
  19. Optogenetic tachypacing facilitates burst-induced arrhythmia in stem cell-derived human atrial engineered heart tissue
    Karl-Felix Müller, Bangfen Pan, Julius Ridder, Jessica Schrapers, Julius Hansen, Tandy M. Meier, Carl Schulz, Tim Stüdemann, Marta Lemme, Julia Krause et al. · 2026 · EP Europace
  20. Targeting PKGIα Cys 42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction
    Jie Su, Yue Zhao, Pierre Coleman, Xiaoping Yang, Mark Holt, Janice Raabe, Friederike Cuello, Ajay M. Shah, Michael J. Shattock, Min Zhang et al. · 2026 · Science Advances
  21. Modeling the Mechanical Characteristics of the Regenerated Tissues of Cardiovascular System With the Use of Patches Based on Tissue Engineering Constructions
    Yuliya A. Terentyeva, Alexander Yu. Gerasimenko, Vladislav V. Shunaev, Olga E. Glukhova · 2019 · IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering
  22. Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin
    Veniamin Y. Sidorov, Tatiana Nikolaevna Sidorova, Philip C. Samson, Ronald S. Reiserer, Clayton M. Britt, M. Diana Neely, Kevin C. Ess, John P. Wikswo · 2024 · Bioengineering
  23. Generation of a biallelic NRAP-knockout mutant from a human iPSC line
    Janice Raabe, Vanessa Lewandowski, Sigrid Fuchs, Alexandra Hammerschmidt, Angelika Piasecki, Ellen Orthey, Elisabeth Krämer, Elisabeth Ehler, Friederike Cuello · 2025 · Stem Cell Research
  24. Nanotechnology in Generation and Biomedical Application of Induced Pluripotent Stem Cells
    Hailin Tang, Mengjie Rui, Chuang Yu, Tao Chu, Chao Li, Zhenzhen Zhan, Hao Cao, Hangwen Li, Zhongmin Liu, Haifa Shen · 2018 · Nano LIFE
  25. Ruxolitinib clears CRYAB p.Arg120Gly aggregates through the ubiquitin-proteasome system
    Erda Alizoti, Leonie Ewald, Simona Parretta, Moritz Meyer-Jens, Ellen Orthey, Christian Conze, Lucie Carrier, Jeffrey M. Robbins, Sonia R. Singh · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  26. High rate triggers increased atrial release of BMP10, a biomarker for atrial fibrillation and stroke, which affects ventricular cardiomyocytes
    Laura C. Sommerfeld, Jessica Schrapers, KF Müller, L Bravo, Bente Siebels, Aaltje Maria Stella Stoter, Bangfen Pan, G Höppner, Christopher O’Shea, Julius Ridder et al. · 2025 · medRxiv
  27. RBFOX2 Autoregulation Promotes Cardiomyocyte Transcriptome Maturation and Differentiation
    Mengmeng Huang, Feria A. Ladha, Yunxia Wang, Michael A. Trembley, Huimin Yin, Rongbin Zheng, Maksymilian Prondzynski, Yashasvi Tharani, Alexander A. Akerberg, Stefan Aigner et al. · 2026 · Circulation Research
  28. OBSOLETE: Myocardial Repair
    Thomas Eschenhagen · 2017 · Elsevier eBooks
  29. Cardiac tissue models
    Joycelyn K. Yip, Megan Laura McCain · 2018 · Elsevier eBooks
  30. Investigation of an Electrospun Nanofibrous, Degradable Polar Hydrophobic Ionic Polyurethane Patch for Cardiac Tissue Regeneration
    Jennifer P. Y. Chan · 2018 · TSpace (University of Toronto)
  31. The role of MAP4K4 in cardiac muscle cell death
    Micaela Jenkins · 2018 · Spiral (Imperial College London)
  32. Análise genética de pacientes portadores de cardiomiopatia arritmogênica do ventrículo direito (CAVD) e caracterização funcional em cardiomiócitos diferenciados (hiPSC-CM)
    Fanny Wulkan · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  33. Development of a myocardial infarction model by the design of a miniaturized 3D culture platform
    Tom Boonen · 2019
  34. Geração de um modelo de células-tronco pluripotentes humanas para estudar os mecanismos moleculares de haploinsuficiência e dominância negativa da Síndrome de Marfan
    Juliana Borsoi · 2020 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  35. Epigenetics in cardiac development and human induced pluripotent stem cells
    Federica De Majo, Gabriela M. Kuster, León J. De Windt · 2021 · Elsevier eBooks
  36. Directing cell differentiation in organ-on-chip devices through microarchitecture and supported lipid bilayers
    Nicole J.L. Zeijen · 2021
  37. The morphology of the elements of the myocardial contractile apparatus question and research prospects
    P.A. Kobeza · 2021 · Morphologia
  38. The Guinea Pig Model in Cardiac Regeneration Research; Current Tissue Engineering Approaches and Future Directions
    Tim Stüdemann, Florian Weinberger · 2022 · Springer eBooks
  39. ABSTRACTS (BY NUMBER)
    Vijayaganapathy Vaithilingam, L.L. Reys, Mireille M.J.P.E. Sthijns, Timo Rademakers, Rick H. W. de Vries, Sami G. Mohammed, D De Bont, M Jetten, Eelco J.P. de Koning, Nizar I. Mourad et al. · 2022 · Tissue Engineering Part A
  40. Biomaterial Control of Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
    2019 · Royal Society of Chemistry eBooks
  41. Myocardial Repair
    Kaja Breckwoldt, Thomas Eschenhagen · 2017 · Elsevier eBooks
  42. Latifolin enhances both survival and cardiomyocyte differentiation of bone marrow mesenchymal stem cells on rat myocardial infarction model
    Ni Zhang, Xiao-Xiao Lai, Lanying Chen, Wenhong Li, Yingying Luo, An Li, Ronghua Liu, Xiaowei Meng · 2022 · Research Square
  43. Modelling, design, fabrication and characterization of engineered human myocardium made with melt electrowriting and cardiac cells derived from hiPSCs
    María Flandes‐Iparraguirre · 2023
  44. Functional modelling of arrhythmias with human cardiac organoids
    Mark L. Pocock · 2024 · Queensland University of Technology
  45. Success and Challenges with Models for Cardiac Translational Research
    Ralf Franz Kettenhofen, Julia Christiane Neubauer · 2024 · Springer eBooks
  46. Biomaterials and stem cells for cardiac dysfunction treatments
    Deepti Singh, Pierre C. Dromel · 2024 · Elsevier eBooks
  47. Success and Challenges with Models for Cardiac Translational Research
    Ralf Franz Kettenhofen, Julia Christiane Neubauer · 2024 · Springer eBooks
  48. Advances in human induced pluripotent stem cell (hiPSC)-based disease modelling in cardiogenetics
    Sandra Hoffmann, Timon Seeger · 2025 · Medizinische Genetik
  49. Targeting C42 in PKGIα alleviates diastolic dysfunction in HFpEF
    Jie Su, Min Zhang, Xiaoping Yang, Mark Holt, Janice Raabe, Friederike Cuello, Ajay M. Shah, Michael J. Shattock, Joseph Robert Burgoyne · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Oxygen Handling Practices for in Vitro Human Pluripotent Stem Cell Cardiomyocyte Differentiation: A Scoping Literature Review
    Lisse Frans, Jeffrey Aalders, Jolanda van Hengel, Alain J. Labro · 2025 · Stem Cell Reviews and Reports
  51. Positive inotropic effects of serotonin in atrial EHT: further proof for an atrial phenotype?
    Muhammed Ikbal Sönmez, Margaret Nandudu, Paul Brunnbauer, Carl Schulz, Birgit Klampe, Thomas Schulze, Arne Hansen, Thomas Eschenhagen A, Torsten Christ · 2025 · Naunyn-Schmiedeberg s Archives of Pharmacology
  52. Generation of a NRAP-overexpressing mutant from a human iPSC line
    Janice Raabe, Sigrid Fuchs, Christa Augustin, Alexandra Hammerschmidt, Elisabeth Krämer, Ellen Orthey, Elisabeth Ehler, Friederike Cuello · 2025 · Stem Cell Research
  53. Field potential duration and its variability as essential parameters for revealing proarrhythmia: problematic aspects of analysis in cardiomyocytes derived from human pluripotent stem cells
    Martin Král, Olga Švecová, Pavel Jurák, Josef Halámek, Milena Šimurdová, Jiří Šimurda, Markéta Bébarová · 2025 · Progress in Biophysics and Molecular Biology
  54. The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
    Jöerg Heeren, Ioannis Evangelakos, Esther Verkade, Folkert Kuipers, Julia Sarah Rohde, Markus Heine, Anna Worthmann, Sebastian Graute, Manka M. Fuh, Karthikeyan Gunasekaran et al. · 2025 · Research Square
  55. Additional file 1 of An arrhythmogenic metabolite in atrial fibrillation
    Julia Krause, Nickel, Alexander, Alexandra Madsen, Hamish M. Aitken‐Buck, Aaltje Maria Stella Stoter, Jessica Schrapers, Ojeda, Francisco, Kira Geiger, Kern, Melanie, Kohlhaas, Michael et al. · 2024 · Figshare
  56. Additional file 2 of NRF2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived ardiomyocytes
    Zhang, Xinyuan, Ye, Liang, Xu, Hao, Zhou, Qin, Tan, Bin, Qin Yi, Yan, Liang, Min Xie, Yin Zhang, Tian, Jie et al. · 2021 · Figshare
  57. Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening
    Elisheva Baruch, Daniel Rosner, Elisabeth Riska, Moran Yadid, Assaf Shapira, Tal Dvir · 2025 · Pharmaceutics
  58. Advances in Internal Organogenesis: Differentiation and Morphogenesis of Human Ventral Cavity Organs
    Muhammad Iqbal Qureshi, Afsar Ali Mian, Irfan Khan · 2026 · Stem Cell Reviews and Reports
  59. Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in LMNA Mutation-Induced Dilated Cardiomyopathy
    Marie Kervella, Charlotta Sophie Behrens, Cécile Peccate, Zoheir Guesmia, Fiorella Carla Grandi, Nathalie Mougenot, Anne Forand, Azzouz Charrabi, Guy Brochier, Ramaroson Andriantsitohaina et al. · 2026 · Circulation Heart Failure
  60. JAK1/2 inhibitor ruxolitinib reduces aggregates in cardiac proteinopathy
    Erda Alizoti, Leonie Ewald, Simona Parretta, Jacob J K March, Moritz Meyer-Jens, Ellen Orthey, Christian Conze, Lucie Carrier, Jeffrey M. Robbins, Sonia R. Singh · 2026 · EMBO Molecular Medicine
  61. The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
    Ioannis Evangelakos, Esther Verkade, Julia K. Rohde, Alex Zaufel, Martin Vargek, Markus Heine, Anna Worthmann, Sebastian Graute, Marceline Manka Fuh, Karthikeyan Gunasekaran et al. · 2026 · Molecular Metabolism
  62. Myocardial Repair
    Kaja Breckwoldt, Thomas Eschenhagen · 2026 · Elsevier eBooks
  63. Length-dependent hypercontractility decoupled from cellular adaptations is the initial phenotype in MYBPC3-haploinsufficient iPSC-derived engineered cardiac tissues
    Tomi Tuomainen, Maike Mona Širinov, Mina Rabiee, Eloi Schmauch, Jussi T. Koivumäki, Kyriaki Galani, M Kellis, Johanna Kuusisto, Robert S. Leigh, Nikolay Naumenko et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes
    Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo · 2026 · BMEMat
  65. Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy
    Laura Sen-Martín, Ángel Fernández‐Trasancos, Miguel Ángel López-Unzu, Agata Bak, Magdalena Zafra-Castellano, Rajiven Srikantharajah, Divya Pathak, Annika J. Klotz, Michel N. Kuehn, Alessia Ferrarini et al. · 2026 · Nature Cardiovascular Research
  66. Xeno-Free Peptide-Functionalized Hydrogels Support hiPSC Encapsulation and In Situ Differentiation into Structurally Mature Cardiomyocytes
    Mohammadjafar Hashemi, Nongmaithem Debeni Devi, Yasaman Kargar Gaz Kooh, Charlotte Chen, Bahareh Bahmani, Ganesh Malayath, Julia Victor, Nathaniel Huebsch · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Three-Dimensional Cardiac Tissue Models for Pharmaceutical Research
    Xiaolu Lu, Baoping Xie, Jianing Zhong, Renjian Xie, Weijie Peng · 2026 · ACS Applied Bio Materials
  68. Phenotype rescue through the restoration of full-length dystrophin using CRISPR/Cas9 genome editing in Duchenne muscular dystrophy patient-derived iPSCs carrying the deletion of two exons
    Davide Rovina, Sofia Milasi, Giusy Di Giuseppe, Josè Manuel Pioner, Marianna Langione, Lucrezia Giammarino, Cecilia Ferrantini, Mattia Chiesa, Francesco Canonico, Domenico D’Amario et al. · 2026 · Genome Medicine
  69. Dynamic BMP10 Release Reflects Atrial Fibrillation Burden in Human Atrial Engineered Heart Tissue
    Lukas von Hacht, Tandy M. Meier, Julius Ridder, Jessica Schrapers, Ann‐Kristin Afflerbach, Marc N. Hirt, Arne Hansen, Paulus F. Kirchhof, Thomas Eschenhagen A, Justus Stenzig et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function
    Xiao-Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides · 2026 · Advanced Materials Technologies
  71. Characterisation of the patient-specific induced pluripotent stem cell line UKEi075-A carrying the heterozygous PRKAG2 frameshift variant c.769_770del (p.E257Kfs*15)
    Benedict Hoffmann, Tim Knochenhauer, Julian Schlobohm, Κωνσταντίνα Σταθοπούλου, Bärbel Maria Ulmer, 柴宮綾, Sandra D. Laufer, Sarina Schäfer, Elisabeth Krämer, Sigrid Fuchs et al. · 2026 · Stem Cell Research
  72. BindingDB Entry 50017258: Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes.
    BindingDB · 2023 · UC San Diego