Drugging the ‘undruggable’ cancer targets
Cited by (949)
Items 101–200 of 949
- Extracellular vesicles in cancer nanomedicineTarasov, Vadim V., Svistunov, Andrey A., Chubarev, Vladimir N., Dostdar, Samira A., Sokolov, Alexander V., Brzecka, Anna, Sukocheva, Olga, Neganova, Margarita E., Klochkov, Sergey G., Somasundaram, Siva G. et al. · 2021 · Seminars in Cancer Biology
- CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and ResearchFahreddin Palaz, Ali Kerem Kalkan, Özgür Can, Ayça Nur Demir, Abdullah Tozluyurt, Ahsen Özcan, Mehmet Özsöz · 2021 · ACS Synthetic Biology
- Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancerMartin Pichler, Cristian Rodriguez‐Aguayo, Su Youn Nam, Mihnea Paul Dragomir, Recep Bayraktar, Simone Anfossi, Erik Knutsen, Cristina Ivan, Enrique Fuentes‐Mattei, Sang Kil Lee et al. · 2020 · Gut
- Inorganic Nanomaterial‐Mediated Gene Therapy in Combination with Other Antitumor Treatment ModalitiesGuanyou Lin, Richard A. Revia, Miqin Zhang · 2020 · Advanced Functional Materials
- MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1Tessa M. Popay, Jing Wang, Clare M. Adams, Gregory Caleb Howard, Simona G. Codreanu, Stacy D. Sherrod, JOHN A. JUN. MCLEAN, Lance R. Thomas, Shelly L. Lorey, Yuichi Machida et al. · 2021 · eLife
- Photopharmacology and photoresponsive drug deliveryYuwei Liu, Tianyi Wang, Weiping Wang · 2025 · Chemical Society Reviews
- PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomasYuan Ren, Chengfeng Bi, Xiaohong Zhao, Tint Lwin, Cheng Wang, Yuan Ji, Ariosto Siqueira Silva, Bijal Dinesh Shah, Bin Fang, Tao Li et al. · 2018 · Journal of Clinical Investigation
- Nanotechnology-Based Strategies to Overcome Current Barriers in Gene DeliveryMirón-Barroso, Sofía, Domènech, Elena B., Trigueros, Sonia · 2021 · International Journal of Molecular Sciences
- Targeting Cbl-b in cancer immunotherapyRyan C. Augustin, Riyue Bao, Jason J. Luke · 2023 · Journal for ImmunoTherapy of Cancer
- GEPIA3: Enhanced drug sensitivity and interaction network analysis for cancer researchYu-Jian Kang, Lingjie Pan, Yiyu Liu, Zhengqin Rong, Jiaxi Liu, Fenglin Liu · 2025 · Nucleic Acids Research
- RNA‐binding motif protein 39 (RBM39): An emerging cancer targetYuewei Xu, Anke M. Nijhuis, Hector C. Keun · 2020 · British Journal of Pharmacology
- MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting NeuroblastomaGanna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero‐Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart‐Ayala, Craig Edward Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö et al. · 2019 · iScience
- Targeting the β-catenin signaling for cancer therapyXue Zhang, Lei Wang, Yi Qu · 2020 · Pharmacological Research
- Extracellular matrix-mediated regulation of cancer stem cells and chemoresistanceYazmin Brown, Susan Hua, Pradeep Singh Tanwar · 2019 · The International Journal of Biochemistry & Cell Biology
- Drugging “undruggable” genes for cancer treatment: Are we making progress?Michael Joe Duffy, John Paul Crown · 2020 · International Journal of Cancer
- Stimuli-activatable PROTACs for precise protein degradation and cancer therapyJing Gao, Lei Yang, Shumin Lei, Feng Zhou, Hui‐Jun Nie, Bo Peng, Tianfeng Xu, Xiaohua Chen, Xiaobao Yang, Chunquan Sheng et al. · 2023 · 中国科学通报:英文版
- Intracellular Protein Delivery: Approaches, Challenges, and Clinical ApplicationsAlexander Chan, Andrew Tsourkas · 2023 · BME Frontiers
- Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad‑spectrum cancer gene therapy - A review of molecular mechanisms for oncologistsErlinda Maria Gordon, Joshua R. Ravicz, Seiya Liu, Sant P. Chawla, Frederick L. Hall · 2018 · Molecular and Clinical Oncology
- Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) DegradersAnja Dölle, Bikash Adhikari, Andreas Krämer, Janik Weckesser, Nicola Berner, Lena M. Berger, Mathias Diebold, Magdalena M. Szewczyk, Dalia Baršytė-Lovejoy, C.H. Arrowsmith et al. · 2021 · Journal of Medicinal Chemistry
- Advances of Artificial Intelligence in Anti-Cancer Drug Design: A Review of the Past DecadeLiuying Wang, Yongzhen Song, Hesong Wang, Xuan Zhang, Meng Wang, Jia He, Shuang Li, Liuchao Zhang, Kang Li, Lei Cao · 2023 · Pharmaceuticals
- Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRASGuowei Yin, Jing Huang, Johnny Petela, Hongmei Jiang, Yuetong Zhang, Siqi Gong, Jiaxin Wu, Bei Liu, Jianyou Shi, Yijun Gao · 2023 · Signal Transduction and Targeted Therapy
- Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancersEdina Wang, Anabel Sorolla, Paula T. Cunningham, Heique Marlis Bogdawa, Samuel J. Beck, Emily Golden, Robert E. Dewhurst, Laura Florez, Mark N. Cruickshank, Katrin Hoffmann et al. · 2018 · Oncogene
- Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNAKeiji Uehara, Toshimasa Harumoto, Asana Makino, Yasuo Koda, Junko Iwano, Yasuhiro Suzuki, Mari Tanigawa, Hiroto Iwai, Kana Asano, Kana Kurihara et al. · 2022 · Nucleic Acids Research
- Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patientsJunichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory M. Alvey, Abraham Avigdor, Wayne R. Buck, Lauren M. Besenhofer, Erwin R. Boghaert, Dong Cheng et al. · 2023 · Communications Medicine
- Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repairLinlin Yang, Changxian Shen, Adriana Estrada‐Bernal, Ryan N. Robb, Moumita Chatterjee, Nikhil Sebastian, Amy Webb, Xiaokui Molly Mo, Wei Chen, Sunil Krishnan et al. · 2021 · Nucleic Acids Research
- Pharmacokinetics and Pharmacodynamics of GalNAc‐Conjugated siRNAsGuohua An · 2023 · The Journal of Clinical Pharmacology
- High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilegeCasey R. Ager, Akash R. Boda, Kimal Rajapakshe, Spencer Thomas Lea, Maria Emilia Di Francesco, Priyamvada Jayaprakash, Ravaen Slay, Brittany Morrow, Rishika Prasad, Meghan A. Dean et al. · 2021 · Journal for ImmunoTherapy of Cancer
- BET Proteins as Attractive Targets for Cancer TherapeuticsJoanna Sarnik, Tomasz Popławski, Paulina Tokarz · 2021 · International Journal of Molecular Sciences
- KRAS Inhibitors– yes but what next? Direct targeting of KRAS– vaccines, adoptive T cell therapy and beyondMisako Nagasaka, Bindu Rani Potugari, Alexis Nguyen, Ammar W. Sukari, Asfar Sohail Azmi, Sai‐Hong Ignatius Ou · 2021 · Cancer Treatment Reviews
- LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferationJin-Yu Liu, Yajing Chen, Huan-Hui Feng, Zhan‐Li Chen, Yunlong Wang, Jine Yang, Shi‐Mei Zhuang · 2021 · Cell Death and Disease
- Machine Learning Informs RNA‐Binding Chemical Space**Kamyar Yazdani, Deondre Jordan, Mo Yang, Christopher R. Fullenkamp, David R. Calabrese, Robert E. Boer, Thomas A. Hilimire, Timothy E. H. Allen, Rabia T. Khan, John S. Schneekloth · 2022 · Angewandte Chemie International Edition
- Defining the condensate landscape of fusion oncoproteinsSwarnendu Tripathi, Hazheen K. Shirnekhi, Scott D. Gorman, Bappaditya Chandra, David W. Baggett, Cheon‐Gil Park, Ramiz Somjee, Benjamin Lang, Seyed Mohammad Hadi Hosseini, Brittany J. Pioso et al. · 2023 · Nature Communications
- Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug TargetsKilian Colas, Daniel Bindl, Hiroaki Suga · 2024 · Chemical Reviews
- Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancerFang Huang, Kenneth E. Huffman, Zixi Wang, Xun Wang, Kailong Li, Feng Cai, Chendong Yang, Ling Cai, T. Shane Shih, Lauren G. Zacharias et al. · 2020 · Journal of Clinical Investigation
- Molecular mechanisms and therapeutic targets in neuroblastomaJohn Inge Johnsen, Cecilia H. Dyberg, Susanne M. Fransson, Malin Wickström · 2018 · Pharmacological Research
- Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent mannerFabiana Gámbaro, Marco Li Calzi, Pablo Fagúndez, Bruno Costa, Gonzalo Greif, Emily R. Mallick, Shawn M. Lyons, Pavel V. Ivanov, Kenneth Whitaker Witwer, Alfonso Cayota et al. · 2019 · RNA Biology
- Trial watch: immune checkpoint blockers for cancer therapyVanpouille-Box, Claire, Lhuillier, Claire, Bezu, Lucillia, Aranda, Fernando, Yamazaki, Takahiro, Kepp, Oliver, Fucikova, Jitka, Spisek, Radek, Demaria, Sandra, Formenti, Silvia C. et al. · 2017 · OncoImmunology
- Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancerDevon R. Blake, Angelina V. Vaseva, Richard G. Hodge, McKenzie P. Kline, Thomas S.K. Gilbert, Vikas Tyagi, Daowei Huang, Gabrielle C. Whiten, Jacob E. Larson, Xiaodong Wang et al. · 2019 · Science Signaling
- Nanotechnologies for the delivery of biologicals: Historical perspective and current landscapeMatilde Durán‐Lobato, Ana M. López-Estévez, Ana Sara Cordeiro, Tamara G. Dacoba, José Crecente‐Campo, Dolores Torres, Marı́a José Alonso · 2021 · Advanced Drug Delivery Reviews
- Current strategies and progress for targeting the “undruggable” transcription factorsJingjing Zhuang, Qian Liu, Dalei Wu, Lu Tie · 2022 · Acta Pharmacologica Sinica
- Targeted Covalent Modification Strategies for Drugging the Undruggable TargetsTomonori Tamura, Masaharu Kawano, Itaru Hamachi · 2025 · Chemical Reviews
- The rise of covalent proteolysis targeting chimerasRonen Gabizon, Nir London · 2021 · Current Opinion in Chemical Biology
- Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potentialLi Na Zhao, Mikael Björklund, Matias J. Caldez, Jie Zheng, Philipp Kaldis · 2021 · Oncogene
- De novo design of peptide binders to conformationally diverse targets with contrastive language modelingSuhaas Bhat, Kalyan Palepu, Lauren Hong, Yiwei Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson et al. · 2025 · Science Advances
- Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood CancersAdam J. Wolpaw, Richard W. Bayliss, Gabriele Büchel, Chi Van Dang, Martin Eilers, William Clay Gustafson, Gwenn M. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon et al. · 2021 · Cancer Research
- Computer-Aided Drug Discovery for Undruggable TargetsQi Sun, Hanping Wang, Juan Xie, Liying Wang, Junxi Mu, Junren Li, Yuhao Ren, Luhua Lai · 2025 · Chemical Reviews
- Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteinsAlexander Chan, Rebecca M. Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J. Bugaj, George M. Burslem, Michael J. Mitchell, Andrew Tsourkas · 2024 · Nature Communications
- Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axisBabita Madan, Nathan Harmston, Gahyathiri Nallan, Alex Montoya, Peter Allen Faull, Enrico G. Petretto, David M. Virshup · 2018 · Journal of Clinical Investigation
- Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastomaEvon Poon, Tong Liang, Yann Jamin, Susanne Walz, Colin Kwok, Anne Hakkert, Karen T. Barker, Zuzanna Urban‐Wójciuk, Khin Thway, Rhamy Zeid et al. · 2020 · Journal of Clinical Investigation
- Activating KRAS mutations in arteriovenous malformations of the brain: frequency and clinicopathologic correlationDavid S. Priemer, Alexander O. Vortmeyer, Shaobo Zhang, Hsim Yee Chang, Kendra L. Curless, Liang Cheng C · 2019 · Human Pathology
- Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious DiseasesNicole LoGiudice, Linh Nguy-Hoang Le, Irene Abuan, Yvette Leizorek, Sigrid C. Roberts · 2018 · Medical Sciences
- Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine ResiduesAlberto Dal Corso, Marco Catalano, Anja Sophie Schmid, Jörg Scheuermann, Dario Neri · 2018 · Angewandte Chemie International Edition
- Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challengesUbanako, Philemon, Mirza, Sheefa, Ruff, Paul, Penny, Clement · 2024 · Frontiers in Molecular Biosciences
- Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in RhabdomyosarcomaThanh Nguyen, Frederic G. Barr · 2018 · Molecules
- Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cellsCristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten Patrick Ade, Marco A. Calzado et al. · 2020 · EMBO Molecular Medicine
- Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein InteractionMacdonald, Jonathan D., Chacón Simon, Selena, Han, Changho, Wang, Feng, Shaw, J. Grace, Howes, Jennifer E., Sai, Jiqing, Yuh, Joannes P., Camper, Demarco, Alicie, Bethany M. et al. · 2019 · Journal of Medicinal Chemistry
- Insulin‐like Growth Factor 2‐Tagged Aptamer Chimeras (ITACs) Modular Assembly for Targeted and Efficient Degradation of Two Membrane ProteinsYuan Tian, Yanyan Miao, Pei Guo, Junyan Wang, Da Han · 2023 · Angewandte Chemie International Edition
- Overcoming Resistance to Drugs Targeting KRAS MutationJiao, Delong, Yang, Shengyu · 2020 · The Innovation
- Recent Advances and Perspectives in Cancer Drug DesignLuma G. Magalhães, Leonardo L. G. Ferreira, Adriano Defini Andricopulo · 2018 · Anais da Academia Brasileira de Ciências
- TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradationKe Li, Feng Wang, Zhao-na Yang, Tingting Zhang, Yufen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiaoxi Lv et al. · 2020 · Nature Communications
- Nanomaterials for Protein Delivery in Anticancer ApplicationsAnne Yau, Jinhyung Lee, Yupeng Chen · 2021 · Pharmaceutics
- Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell DeathLucia Cottone, Adam P. Cribbs, Garima Khandelwal, Graham Wells, Lorena Ligammari, Martin Philpott, Anthony Tumber, Patrick Lombard, Edward S. Hookway, Tamás Szommer et al. · 2020 · Cancer Research
- USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell CarcinomaCristian Prieto‐Garcia, Ines Tomašković, Varun Jayeshkumar Shah, Ivan Đikić, Markus E. Diefenbacher · 2021 · Cells
- A platform for the rapid synthesis of proteolysis targeting chimeras (Rapid-TAC) under miniaturized conditionsLe Guo, Yaxian Zhou, Xueqing Nie, Zhongrui Zhang, Zhen Zhang, Chunrong Li, Taobo Wang, Weiping Tang · 2022 · European Journal of Medicinal Chemistry
- PAX3-FOXO1: Zooming in on an “undruggable” targetMarco Wachtel, Beat W. Schäfer · 2017 · Seminars in Cancer Biology
- Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision HealthFeixiong Cheng, Han Liang, Atul Janardhan Butte, Charis Eng, Ruth Nussinov · 2018 · Pharmacological Reviews
- Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 TranscriptionLei Mao, Li Liu, Tao Zhang, Hao Qin, Xiaoyan Wu, Yong Xu · 2020 · Frontiers in Cell and Developmental Biology
- The Ins and Outs of RAS Effector ComplexesChristina Kiel, David Matallanas, Walter Kölch · 2021 · Biomolecules
- Photodynamic Therapy for ras -Driven Cancers: Targeting G-Quadruplex RNA Structures with Bifunctional Alkyl-Modified PorphyrinsAnnalisa Ferino, Giulia Nicoletto, Francesca D’Este, Sonia Zorzet, Sara Lago, Sara N. Richter, Alexander S. Tikhomirov, Andrey Egorovich Shchekotikhin, Luigi Emilio Xodo · 2020 · Journal of Medicinal Chemistry
- Total Synthesis and Target Identification of the Curcusone DiterpenesChengsen Cui, Brendan G. Dwyer, Chang Liu, Daniel Abegg, Zhong-Jian Cai, Dominic G. Hoch, Xianglin Yin, Nan Qiu, Jie‐Qing Liu, Alexander Adibekian et al. · 2021 · Journal of the American Chemical Society
- Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscopeSinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You et al. · 2022 · Acta Pharmaceutica Sinica B
- Exploring liver cancer biology through functional genetic screensCun Wang, Ying Cao, Chen Guang Yang, René Bernards, Wenxin Qin · 2021 · Nature Reviews Gastroenterology & Hepatology
- PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosisChengcheng Shi, Huapeng Zhang, Penglei Wang, Kai Wang, Denghui Xu, Haitao Wang, Li Yin, Shuijun Zhang, Yi Zhang · 2019 · Cell Death and Disease
- Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer CellsZhe Sun, Ziheng Zhang, Qiao-Qi Wang, Ji-Long Liu · 2022 · Cancer Research
- Screening for molecular glues – Challenges and opportunitiesGeoffrey A. Holdgate, Catherine Bardelle, Sophia K. Berry, Alice Lanne, Maria Emanuela Cuomo · 2023 · SLAS DISCOVERY
- KRAS: the Achilles’ heel of pancreas cancer biologyKristina Drizyte‐Miller, Taiwo Talabi, Ashwin Somasundaram, Adrienne D. Cox, Channing J. Der · 2025 · Journal of Clinical Investigation
- Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/CytokinesMichael R. Pranzatelli · 2018 · Frontiers in Immunology
- The paradox of cancer genes in non-malignant conditions: implications for precision medicineJacob J. Adashek, Shumei Kato, Scott Michael Lippman, Razelle Kurzrock · 2020 · Genome Medicine
- Drug design targeting active posttranslational modification protein isoformsFanwang Meng, Zhongjie T. Liang, Kehao Zhao, Cheng Luo · 2020 · Medicinal Research Reviews
- Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital AgeDexter Kai Hao Thng, Tan Boon Toh, Edward Kai‐Hua Chow · 2021 · Trends in Pharmacological Sciences
- Regulation of Ferroptosis Pathway by UbiquitinationXinbo Wang, Yanjin Wang, Zan Li, Jieling Qin, Ping Wang · 2021 · Frontiers in Cell and Developmental Biology
- A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing TumorsYing Xu, Qingfeng Yu, Ping Wang, Zhaoxing Wu, Lei Zhang, Shuigao Wu, Mengyuan Li, Bowen Wu, Hongzhi Li, Haifeng Zhuang et al. · 2022 · Advanced Science
- Targeting Myc-driven stress addiction in colorectal cancerHaris Saeed, Brian J. Leibowitz, Lin Zhang, Jian Yu · 2023 · Drug Resistance Updates
- Chemoproteomics, A Broad Avenue to Target DeconvolutionYihui Gao, Mingzhe Ma, Wenyang Li, Xiaoguang Lei · 2023 · Advanced Science
- Reliable method for predicting the binding affinity of RNA-small molecule interactions using machine learningSowmya Ramaswamy Krishnan, Arijit Roy, M. Michael Gromiha · 2024 · Briefings in Bioinformatics
- To Wnt or Lose: The Missing Non-Coding Linc in Colorectal CancerPeng Shen, Martin Pichler, Meng Chen, George A. Călin, Hui Yvonne Ling · 2017 · International Journal of Molecular Sciences
- Emerging targeted protein degradation tools for innovative drug discovery: From classical PROTACs to the novel and beyondYue Zhong, Fanglian Chi, Hanyu Wu, Yunxiao Liu, Zhancheng Xie, Wenlong Huang, Wei Shi, Hai Qian · 2022 · European Journal of Medicinal Chemistry
- Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scaleSevan Habeshian, Manuel L. Merz, Gontran Sangouard, Mothukuri Ganesh Kumar, Mischa Schüttel, Zsolt Bognár, Cristina Díaz‐Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti et al. · 2022 · Nature Communications
- Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challengesKhalil Choucair, Hafsa Imtiaz, Md. Hafiz Uddin, Misako Nagasaka, Mohammad Najeeb Al-Hallak, Philip A. Philip, Bassel El-Rayes, Boris Pasche, Asfar Sohail Azmi · 2025 · Signal Transduction and Targeted Therapy
- A Case of Identity: HOX Genes in Normal and Cancer Stem CellsJessica Smith, Ahmad Zyoud, C. Allegrucci · 2019 · Cancers
- TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic painMoses M. Kasembeli, Pooja Singhmar, Jiacheng Ma, Jules D. Edralin, Yongfu Tang, Clydell Adams, Cobi J. Heijnen, Annemieke Kavelaars, David John Tweardy · 2021 · Biochemical Pharmacology
- Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYCPengwen Chen, Wenqian Yang, Taehun Hong, Takuya Miyazaki, Anjaneyulu Dirisala, Kazunori Kataoka, Horacio Cabral · 2022 · Biomaterials
- Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc ProteinYuchun Wang, Gang Yang, Xinyu Zhang, Ruoling Bai, Deyu Yuan, Denghui Gao, Qianyu He, Yi Yuan, Xinghe Zhang, Junchuang Kou et al. · 2024 · Advanced Science
- An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challengeUgo Perricone, Maria Rita Gulotta, Jessica Lombino, Barbara Parrino, Stella Cascioferro, Patrizia Diana, Girolamo Cirrincione, Alessandro Padova · 2018 · MedChemComm
- The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma PathophysiologyFengjuan Fan, Klaus Podar · 2021 · Cancers
- Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug DiscoveryRocío Marisol Espinoza-Chávez, Alessandra Salerno, Anastasia Liuzzi, Andrea Ilari, Andrea Milelli, Elisa Uliassi, María Laura Bolognesi · 2022 · ACS Bio & Med Chem Au
- Demystifying the Druggability of the MYC Family of OncogenesNishant M. Karadkhelkar, Mingliang Lin, Lisa M. Eubanks, Kim D. Janda · 2023 · Journal of the American Chemical Society
- TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancerWen-Long Ye, Long Huang, Xiaoqin Yang, Shan Wan, Wen-Juan Gan, Yun Yang, Xiaoshun He, Feng Liu, Xin Guo, Yi-Xuan Liu et al. · 2024 · Proceedings of the National Academy of Sciences
- Triazol: A Privileged Scaffold for Proteolysis Targeting ChimerasLiwen Xia, Meng-Yu Ba, Wei Liu, Weyland Cheng, Chao-Ping Hu, Qing Zhao, Yongfang Yao, Moran Sun, Yongtao Duan · 2019 · Future Medicinal Chemistry
- Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancerJunru Feng, Hui Juan Lu, Wenhao Ma, Wenjing Tian, Zhuan Lu, Hongying Yang, Yongping Cai, Pengfei Cai, Yuchen Sun, Zilong Zhou et al. · 2022 · Protein & Cell