Drugging the ‘undruggable’ cancer targets

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Items 101–200 of 949

  1. Extracellular vesicles in cancer nanomedicine
    Tarasov, Vadim V., Svistunov, Andrey A., Chubarev, Vladimir N., Dostdar, Samira A., Sokolov, Alexander V., Brzecka, Anna, Sukocheva, Olga, Neganova, Margarita E., Klochkov, Sergey G., Somasundaram, Siva G. et al. · 2021 · Seminars in Cancer Biology
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  5. MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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    Yuwei Liu, Tianyi Wang, Weiping Wang · 2025 · Chemical Society Reviews
  7. PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas
    Yuan Ren, Chengfeng Bi, Xiaohong Zhao, Tint Lwin, Cheng Wang, Yuan Ji, Ariosto Siqueira Silva, Bijal Dinesh Shah, Bin Fang, Tao Li et al. · 2018 · Journal of Clinical Investigation
  8. Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery
    Mirón-Barroso, Sofía, Domènech, Elena B., Trigueros, Sonia · 2021 · International Journal of Molecular Sciences
  9. Targeting Cbl-b in cancer immunotherapy
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  11. RNA‐binding motif protein 39 (RBM39): An emerging cancer target
    Yuewei Xu, Anke M. Nijhuis, Hector C. Keun · 2020 · British Journal of Pharmacology
  12. MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
    Ganna Oliynyk, María Victoria Ruiz-Pérez, Lourdes Sainero‐Alcolado, Johanna Dzieran, Hanna Zirath, Héctor Gallart‐Ayala, Craig Edward Wheelock, Henrik J. Johansson, Roland Nilsson, Janne Lehtiö et al. · 2019 · iScience
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  14. Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance
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  15. Drugging “undruggable” genes for cancer treatment: Are we making progress?
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  16. Stimuli-activatable PROTACs for precise protein degradation and cancer therapy
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  18. Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad‑spectrum cancer gene therapy - A review of molecular mechanisms for oncologists
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  19. Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders
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  20. Advances of Artificial Intelligence in Anti-Cancer Drug Design: A Review of the Past Decade
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  21. Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
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  22. Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers
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  25. Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair
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  27. High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege
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  28. BET Proteins as Attractive Targets for Cancer Therapeutics
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  31. Machine Learning Informs RNA‐Binding Chemical Space**
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  33. Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug Targets
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  34. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
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  38. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer
    Devon R. Blake, Angelina V. Vaseva, Richard G. Hodge, McKenzie P. Kline, Thomas S.K. Gilbert, Vikas Tyagi, Daowei Huang, Gabrielle C. Whiten, Jacob E. Larson, Xiaodong Wang et al. · 2019 · Science Signaling
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  40. Current strategies and progress for targeting the “undruggable” transcription factors
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  41. Targeted Covalent Modification Strategies for Drugging the Undruggable Targets
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  43. Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
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  45. Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
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  46. Computer-Aided Drug Discovery for Undruggable Targets
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  47. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins
    Alexander Chan, Rebecca M. Haley, Mohd Altaf Najar, David Gonzalez-Martinez, Lukasz J. Bugaj, George M. Burslem, Michael J. Mitchell, Andrew Tsourkas · 2024 · Nature Communications
  48. Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis
    Babita Madan, Nathan Harmston, Gahyathiri Nallan, Alex Montoya, Peter Allen Faull, Enrico G. Petretto, David M. Virshup · 2018 · Journal of Clinical Investigation
  49. Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma
    Evon Poon, Tong Liang, Yann Jamin, Susanne Walz, Colin Kwok, Anne Hakkert, Karen T. Barker, Zuzanna Urban‐Wójciuk, Khin Thway, Rhamy Zeid et al. · 2020 · Journal of Clinical Investigation
  50. Activating KRAS mutations in arteriovenous malformations of the brain: frequency and clinicopathologic correlation
    David S. Priemer, Alexander O. Vortmeyer, Shaobo Zhang, Hsim Yee Chang, Kendra L. Curless, Liang Cheng C · 2019 · Human Pathology
  51. Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases
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  52. Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues
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  53. Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges
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  54. Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma
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  55. Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells
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  56. Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction
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  57. Insulin‐like Growth Factor 2‐Tagged Aptamer Chimeras (ITACs) Modular Assembly for Targeted and Efficient Degradation of Two Membrane Proteins
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  58. Overcoming Resistance to Drugs Targeting KRAS Mutation
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  59. Recent Advances and Perspectives in Cancer Drug Design
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  60. TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
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  61. Nanomaterials for Protein Delivery in Anticancer Applications
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  62. Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death
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  65. PAX3-FOXO1: Zooming in on an “undruggable” target
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