Shokat, Kevan M.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A., & Shokat, K. M. (2013) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 2,557

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,313

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Knight, Z. A., Gonzalez, B., Feldman, M. E., Zunder, E. R., Goldenberg, D. D., Williams, O., Loewith, R., Stokoe, D., Balla, A., Toth, B., et al. (2006) · Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,174

Drugging the ‘undruggable’ cancer targets

Dang, C. V., Reddy, E. P., Shokat, K. M., & Soucek, L. (2017) · Nature Reviews Cancer

Protein Kinase Regulation and GTPase SignalingProtein Degradation and Inhibitors

Cited by 927

Targets of the cyclin-dependent kinase Cdk1

Ubersax, J. A., Woodbury, E. L., Quang, P. N., Paraz, M., Blethrow, J. D., Shah, K., Shokat, K. M., & Morgan, D. O. (2003) · Nature

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 892

Targeting the cancer kinome through polypharmacology

Knight, Z. A., Lin, H., & Shokat, K. M. (2010) · Nature reviews. Cancer

Cancer Mechanisms and TherapyProtein Kinase Regulation and GTPase Signaling

Cited by 674

The unfolded protein response signals through high-order assembly of Ire1

Korennykh, A. V., Egea, P. F., Korostelev, A. A., Finer-Moore, J., Zhang, C., Shokat, K. M., Stroud, R. M., & Walter, P. (2009) · Nature

Endoplasmic Reticulum Stress and DiseaseRNA Research and Splicing

Cited by 656

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Ostrem, J. M. L., & Shokat, K. M. (2016) · Nature Reviews Drug Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 641

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Rodrik-Outmezguine, V. S., Okaniwa, M., Yao, Z., Novotny, C. J., McWhirter, C., Banaji, A., Won, H., Wong, W., Berger, M., de Stanchina, E., et al. (2016) · Nature

PI3K/AKT/mTOR signaling in cancerAdvanced Breast Cancer Therapies

Cited by 479

Rewiring of Genetic Networks in Response to DNA Damage

Bandyopadhyay, S., Mehta, M., Kuo, D., Sung, M.-K., Chuang, R., Jaehnig, E. J., Bodenmiller, B., Licon, K., Copeland, W., Shales, M., et al. (2010) · Science

Fungal and yeast genetics researchDNA Repair Mechanisms

Cited by 447

A surface on the androgen receptor that allosterically regulates coactivator binding

Estébanez-Perpiñá, E., Arnold, L. A., Nguyen, P., Rodrigues, E. D., Mar, E., Bateman, R., Pallai, P., Shokat, K. M., Baxter, J. D., Guy, R. K., et al. (2007) · Proceedings of the National Academy of Sciences

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 307

A neo-substrate that amplifies catalytic activity of Parkinson's-disease-related kinase PINK1

Hertz, N. T., Berthet, A., Sos, M. L., Thorn, K. S., Burlingame, A. L., Nakamura, K., & Shokat, K. M. (2013) · Cell

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 275

Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species

Beltrao, P., Trinidad, J. C., Fiedler, D., Roguev, A., Lim, W. A., Shokat, K. M., Burlingame, A. L., & Krogan, N. J. (2009) · PLoS Biology

Fungal and yeast genetics researchAdvanced Proteomics Techniques and Applications

Cited by 188

KRAS G12C inhibition produces a driver-limited state revealing collateral dependencies

Lou, K., Steri, V., Ge, A. Y., Hwang, Y. C., Yogodzinski, C. H., Shkedi, A. R., Choi, A. L. M., Mitchell, D. C., Swaney, D. L., Hann, B., et al. (2019) · Science Signaling

Protein Kinase Regulation and GTPase SignalingCancer Genomics and Diagnostics

Cited by 175

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

Zhang, Z., Morstein, J., Ecker, A. K., Guiley, K. Z., & Shokat, K. M. (2022) · Journal of the American Chemical Society

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 159

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)

Zhang, Z., Guiley, K. Z., & Shokat, K. M. (2022) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 153

A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy

Zhang, Z., Rohweder, P. J., Ongpipattanakul, C., Basu, K., Bohn, M.-F., Dugan, E. J., Steri, V., Hann, B., Shokat, K. M., & Craik, C. S. (2022) · Cancer Cell

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 136

Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.

Ultanir, S. K., Hertz, N. T., Li, G., Ge, W.-P., Burlingame, A. L., Pleasure, S. J., Shokat, K. M., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 131

GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf

Zhang, Z., Gao, R., Hu, Q., Peacock, H., Peacock, D. M., Dai, S., Shokat, K. M., & Suga, H. (2020) · ACS Central Science

Protein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis

Cited by 124

KRAS is vulnerable to reversible switch-II pocket engagement in cells

Vasta, J. D., Peacock, D. M., Zheng, Q., Walker, J. A., Zhang, Z., Zimprich, C. A., Thomas, M. R., Beck, M. T., Binkowski, B. F., Corona, C. R., et al. (2022) · Nature Chemical Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 115

Site-specific incorporation of phosphotyrosine using an expanded genetic code

Hoppmann, C., Wong, A., Yang, B., Li, S., Hunter, T., Shokat, K. M., & Wang, L. (2017) · Nature Chemical Biology

Chemical Synthesis and AnalysisRNA and protein synthesis mechanisms

Cited by 112

Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications

Gomez-Sjoberg, R., Leyrat, A. A., Houseman, B. T., Shokat, K., & Quake, S. R. (2010) · Analytical Chemistry

Microfluidic and Capillary Electrophoresis Applications3D Printing in Biomedical Research

Cited by 104

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability

Guiley, K. Z., & Shokat, K. M. (2023) · Cancer Discovery

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 102