Targeting Autophagy in Cancer

Levy, Jean M. Mulcahy, Towers, Christina G., Thorburn, Andrew·2017·Nature Reviews Cancer

Cited by (1,004)

Items 301–400 of 1,004

  1. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
    Daric J. Wible, Hsueh‐Ping Chao, Dean G. Tang, Shawn B. Bratton · 2019 · Cell Discovery
  2. Autophagy Modulation as a Treatment of Amyloid Diseases
    Zoe Mputhia, Eugene Hone, Timir Tripathi, Timothy J. Sargeant, Ralph Nigel Martins, Prashant Bharadwaj · 2019 · Molecules
  3. Autophagy, an accomplice or antagonist of drug resistance in HCC?
    Yafei Wu, Jigang Zhang, Qin Li · 2021 · Cell Death and Disease
  4. Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
    Dong‐Jun Fu, Ting Wang · 2023 · Journal of Hematology & Oncology
  5. A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
    Peter Edward Hall, Rachel Lewis, Nelofer Syed, Richard E Shaffer, Jane Evanson, Stephen M. Ellis, Matthew Williams, Xiaoxing Feng, Amanda L. Johnston, Jim A. Thomson et al. · 2019 · Clinical Cancer Research
  6. Role of autophagy in osteosarcoma
    Olivier Camuzard, Sabine Santucci‐Darmanin, Georges F. Carle, Valérie Pierrefite‐Carle · 2019 · Journal of bone oncology
  7. Crosstalk between metabolism and cell death in tumorigenesis
    Shichao Yang, Caden Hu, Xiaomei Chen, Yi Tang, Juanjuan Li, Hanqing Yang, Yi Yang, Binwu Ying, Xue Xiao, Shang‐Ze Li et al. · 2024 · Molecular Cancer
  8. Crosstalk between cancer-associated fibroblasts and regulated cell death in tumors: insights into apoptosis, autophagy, ferroptosis, and pyroptosis
    Cong Chen, Jian Liu, Xia Lin, Aizhai Xiang, Qianwei Ye, Jufeng Guo, Rui Tao, Jian Xu, Shufang Hu · 2024 · Cell Death Discovery
  9. NNMT depletion contributes to liver cancer cell survival by enhancing autophagy under nutrient starvation
    Ji Hye Shin, Chang Wook Park, Gyesoon Yoon, Sun Mi Hong, Kwan Yong Choi · 2018 · Oncogenesis
  10. SNHG14 enhances gemcitabine resistance by sponging miR-101 to stimulate cell autophagy in pancreatic cancer
    Xiufeng Zhang, Ping Zhao, Caihong Wang, Ben-Ru Xin · 2019 · Biochemical and Biophysical Research Communications
  11. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy
    Qianqian Cao, Xue You, Lijiao Xu, Lin Wang, Yan Chen · 2019 · Autophagy
  12. ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival
    Hao Zhang, Peng Xia, Jie Liu, Zhang Chen, Weijie Ma, Yufeng Yuan · 2021 · International Journal of Biological Sciences
  13. Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma
    Jie Yao, Shuming Tang, Chenyan Shi, Yunzhi Lin, Lanlan Ge, Qinghua Chen, Baoru Ou, Dongyu Liu, Yuyang Miao, Qiujie Xie et al. · 2022 · Autophagy
  14. Exploring cellular uptake, accumulation and mechanism of action of a cationic Ru-based nanosystem in human preclinical models of breast cancer
    Marialuisa Piccolo, Gabriella Misso, Maria Grazia Ferraro, Claudia Riccardi, Antonella Capuozzo, Mayra Rachele Zarone, Francesco Μaione, Marco Trifuoggi, Paola Stiuso, Gerardino D’Errico et al. · 2019 · Scientific Reports
  15. Mitophagy Receptors in Tumor Biology
    Yangchun Xie, Jiao Liu, Rui Kang, Daolin Tang · 2020 · Frontiers in Cell and Developmental Biology
  16. Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD‐L1 Expression for Circumventing Immune Resistance of Cancer
    Fengqi Zhou, Jing Gao, Yang Tang, Zhifeng Zou, Shi Jiao, Zhaocai Zhou, Hui‐Xiong Xu, Zhi Ping Xu, Haijun Yu, Zhiai Xu · 2021 · Advanced Materials
  17. Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine
    Wenfeng Zhang, Cun Liu, Jie Li, Yi‐Ping Lu, Huayao Li, Jing Zhuang, Xin Ren, Mengmeng Wang, Changgang Sun · 2022 · The American Journal of Chinese Medicine
  18. Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy
    Jing Jin, Adrian Britschgi, Anna M. Schläfli, Magali Humbert, Deborah Shan, Jasmin Batliner, Elena A. Federzoni, Marion Ernst, Bruce Edward Torbett, Shída Yousefi et al. · 2018 · Oxidative Medicine and Cellular Longevity
  19. LncRNA-ATB promotes autophagy by activating Yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma
    Chuanzhuo Wang, Guangxin Yan, Deshuo Dong, Xin He, Zhaoyu Liu · 2019 · World Journal of Gastroenterology
  20. Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma
    Alfredo Cruz‐Gregorio, Imelda Martínez-Ramírez, José Pedraza‐Chaverrí, Marcela Lizano · 2019 · Cancers
  21. Current Outlook on Autophagy in Human Leukemia: Foe in Cancer Stem Cells and Drug Resistance, Friend in New Therapeutic Interventions
    Katharina Rothe, Vanessa Porter, Xiaoyan Jiang · 2019 · International Journal of Molecular Sciences
  22. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner
    Sergio Castro‐Gonzalez, Yuhang Shi, Marta Colomer-Lluch, Ying Song, Kaitlyn Mowery, Sharilyn Almodóvar, Anju Bansal, Frank Kirchhoff, Konstantin M. J. Sparrer, Chengyu Liang et al. · 2020 · Autophagy
  23. Non-Apoptotic Cell Death Signaling Pathways in Melanoma
    Mariusz L. Hartman · 2020 · International Journal of Molecular Sciences
  24. Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years
    Jianbo Zhou, Yali Ren, Lu Tan, Xiaominting Song, Miao Wang, Yuzhi Li, Zhixing Cao, Chuanjie Guo · 2020 · Biomedicine & Pharmacotherapy
  25. Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer
    Jae Ryoung Hwang, Woo Young Kim, Young‐Jae Cho, Ji‐Yoon Ryu, Jung‐Joo Choi, Soo Young Jeong, Myeong-Sun Kim, Ji Hye Kim, E Sun Paik, Yoo-Young Lee et al. · 2020 · Cell Death and Disease
  26. The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe?
    Jingli Xu, Yuan Li, Yancheng Tang, Zhiyuan Xu, Han-Dong Xu, Xiangdong Cheng, Jiang‐Jiang Qin · 2020 · Frontiers in Cell and Developmental Biology
  27. Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
    Chenchu Lin, Alicia Marie Blessing, Thomas L. Pulliam, Yan Shi, Sandi R. Wilkenfeld, Jenny J. Han, Mollianne M. Murray, Alexander H. Pham, Kevin Duong, Sonja N. Brun et al. · 2021 · Oncogene
  28. Cuproptosis-related gene index: A predictor for pancreatic cancer prognosis, immunotherapy efficacy, and chemosensitivity
    Xu‐Feng Huang, Shujing Zhou, Ying Liu, J Tóth, Hajdu András · 2022 · Frontiers in Immunology
  29. Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
    Leilei Wang, Chuan Wang, Xuan Li, Zhuo-Ying Tao, Wangyong Zhu, Yu‐Xiong Su, Wing Shan Choi · 2023 · Cellular & Molecular Biology Letters
  30. Nanomedicine-induced programmed cell death in cancer therapy: mechanisms and perspectives
    Luobin Lin, He Wanxin, Yingxin Guo, Qinzhou Zheng, Liang Zefeng, Wu Danyang, Li Huaqin · 2024 · Cell Death Discovery
  31. Differential effects of N‐TiO2 nanoparticle and its photo‐activated form on autophagy and necroptosis in human melanoma A375 cells
    Zahra Mohammadalipour, Marveh Rahmati, Alireza Khataee, Mohammad Amin Moosavi · 2020 · Journal of Cellular Physiology
  32. Autophagy-related gene P4HB: a novel diagnosis and prognosis marker for kidney renal clear cell carcinoma
    Longxiang Xie, Huimin Li, Lu Zhang, Xiaoyu Ma, Yifang Dang, J.J. Guo, Jiahao Liu, Linna Ge, Fangmei Nan, Huan Dong et al. · 2020 · Aging
  33. Hybrid nanoparticle composites applied to photodynamic therapy: strategies and applications
    Chao Zhang, Weizhi Chen, Taixing Zhang, Xiqun Jiang, Yong Hu · 2020 · Journal of Materials Chemistry B
  34. The Emerging Roles of Autophagy-Related MicroRNAs in Cancer
    Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu et al. · 2020 · International Journal of Biological Sciences
  35. Knockdown lncRNA CRNDE enhances temozolomide chemosensitivity by regulating autophagy in glioblastoma
    Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu et al. · 2021 · Cancer Cell International
  36. Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer
    Jin Chi Zhang, Ling Zou, Danfeng Shi, Jie Liu, Jifa Zhang, Rongyan Zhao, Guan Wang, Lan Zhang, Liang Ouyang, Bo Liu · 2021 · Journal of Medicinal Chemistry
  37. A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB
    Yuqi Lin, Qiqi Shi, Guang Yang, Fuchun Shi, Yang Zhou, Tongtong Wang, Peng Xu, Peifeng Li, Zaizhou Liu, Hanyin Sun et al. · 2023 · Proceedings of the National Academy of Sciences
  38. Cuproptosis-Inducing Functional Nanocomposites for Enhanced and Synergistic Cancer Radiotherapy
    Tiaoyan Jiang, Tian-Ying Jia, Yipengchen Yin, Tianyu Li, Xinran Song, Wei Jie Feng, Sheng Wang, Li Ding, Yu Chen, Qin Zhang · 2025 · ACS Nano
  39. Physiological and oncogenic roles of the PRL phosphatases
    Serge Hardy, Elie Kostantin, Teri Hatzihristidis, Yevgen Zolotarov, Noriko Uetani, Michel L. Tremblay · 2018 · FEBS Journal
  40. USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
    Marzia Raimondi, Daniela Cesselli, Carla Di Loreto, Francesco La Marra, Claudio Schneider, Francesca Demarchi · 2018 · Autophagy
  41. Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer
    Chunli Wu, Liang Yang, Xun Qi, Taifang Wang, Meng Li, Ke Xu · 2018 · Cancer Management and Research
  42. Epigenetic modifications of autophagy in cancer and cancer therapeutics
    Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Kewal Kumar Mahapatra, Srimanta Patra, Soumya R. Mishra, Bishnu Prasad Behera, Sujit K. Bhutia · 2019 · Seminars in Cancer Biology
  43. Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
    Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni, Gabriella D’Orazi · 2019 · Journal of Experimental & Clinical Cancer Research
  44. Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7
    Ling Ma, Zhangding Wang, Mengyan Xie, Yunlin Quan, Weiyou Zhu, Fengming Yang, Chenhui Zhao, Yu Jing Fan, Na Fang, Huning Jiang et al. · 2020 · Cell Death and Disease
  45. Identification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients
    Jieping Qiu, Mengyu Sun, Yaoqun Wang, Bo Chen · 2020 · Cancer Cell International
  46. Mitochondria Participate in Chemoresistance to Cisplatin in Human Ovarian Cancer Cells
    Luca X. Zampieri, Debora Grasso, Caroline Bouzin, Davide Brusa, Rodrigue Rossignol, Pierre Sonveaux · 2020 · Molecular Cancer Research
  47. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD‐L1
    Hui Li, Xinwei Kuang, Long Liang, Youqiong Ye, YongChang Zhang, Jialu Li, Fangyu Ma, Juan Tao, Guang Lei, Shuang Zhao et al. · 2020 · Advanced Science
  48. The HSF1/miR-135b-5p axis induces protective autophagy to promote oxaliplatin resistance through the MUL1/ULK1 pathway in colorectal cancer
    Huiya Wang, Xia Wang, Haiyang Zhang, Ting Deng, Rui Liu, Ying Liu, Hongli Li, Ming Bai, Tao Ning, Junyi Wang et al. · 2021 · Oncogene
  49. Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
    Alberto Ruiz Priego, Emilio González Parra, Sebastián Mas, José Luis Morgado‐Pascual, Marta Ruiz‐Ortega, Sandra Rayego‐Mateos · 2021 · International Journal of Molecular Sciences
  50. The functions and regulatory pathways of S100A8/A9 and its receptors in cancers
    Huimin Zhou, Cong Zhao, Rong‐Guang Shao, Yanni Xu, Wuli Zhao · 2023 · Frontiers in Pharmacology
  51. Aberrant regulation of autophagy in mammalian diseases
    Wei Dong Xie, Jun Yu Zhou · 2018 · Biology Letters
  52. Protein restriction and cancer
    Jie Yin, Wenkai Ren, Xingguo Huang, Tiejun Li, Yulong Yin · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  53. Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy
    Jiangbo Wang, Xiu-Rong Ren, Hailan Piao, Shengli Zhao, Takuya Osada, Richard T. Premont, Robert A. Mook, Michael Andrew Morse, Herbert Kim Lyerly, Wei Chen · 2019 · Biochemical Journal
  54. PCDH17 Increases the Sensitivity of Colorectal Cancer to 5-Fluorouracil Treatment by Inducing Apoptosis and Autophagic Cell Death
    Shuiping Liu, Haoming Lin, Da Wang, Qiang Li, Hong Luo, Guoxiong Li, Xiaohui Chen, Yongqiang Li, Peng Chen, Bingtao Zhai et al. · 2019 · Signal Transduction and Targeted Therapy
  55. Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects
    Jun Pan, Chenghui Yang, Jiang Zhou, Jian Huang · 2019 · Cancer Management and Research
  56. Silk Fibroin-Coated Nanoagents for Acidic Lysosome Targeting by a Functional Preservation Strategy in Cancer Chemotherapy
    Mixiao Tan, Weiwei Liu, Fengqiu Liu, Wei Zhang, Hui Gao, Juan Cheng, Yu Chen, Zhigang Wang, Yang Cao, Haitao Ran · 2019 · Theranostics
  57. Beclin 1–ATG14L Protein–Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I
    Ivan Pavlinov, Maryna Salkovski, Leslie N. Aldrich · 2020 · Journal of the American Chemical Society
  58. Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy
    Sahib Zada, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Omar Elashkar, Deok Ryong Kim · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  59. Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents
    Patryk Nowakowski, Renata Markiewicz‐Żukowska, Joanna Bielecka, Konrad Mielcarek, Monika Grabia, Katarzyna Socha · 2021 · Biomedicine & Pharmacotherapy
  60. Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
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  62. Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme
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  63. Autophagy and cancer cell metabolism
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  64. Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR‐22‐3p
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  65. Autophagy Function and Dysfunction: Potential Drugs as Anti-Cancer Therapy
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  66. Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes
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  67. Upregulation of KCNQ1OT1 promotes resistance to stereotactic body radiotherapy in lung adenocarcinoma by inducing ATG5/ATG12-mediated autophagy via miR-372-3p
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  68. Multi‐Targeted Peptide‐Modified Gold Nanoclusters for Treating Solid Tumors in the Liver
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  69. Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
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  70. The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members
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  71. Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer
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  72. The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy
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  73. TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis
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  74. Melatonin as an endogenous regulator of diseases: The role of autophagy
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  75. Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB
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  90. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells
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  91. Exogenous Let-7a-5p Induces A549 Lung Cancer Cell Death Through BCL2L1-Mediated PI3Kγ Signaling Pathway
    Shuyin Duan, Songcheng Yu, Yuan Teng, Sanqiao Yao, Lin Zhang · 2019 · Frontiers in Oncology
  92. Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development
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  93. Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy.
    Kenneth D. Tompkins, Andrew M. Thorburn · 2019 · Europe PMC (PubMed Central)
  94. Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells
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  95. Targeting Autophagy to Treat Cancer: Challenges and Opportunities
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  99. Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy
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