The DOI matches its Crossref record; 140 of the 141 references it cites were found in a registry or an index.
Targeting autophagy in cancer
Open accessAbstract
Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.
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In the citing paper
“Proficient autophagic responses (which are under tight transcriptional and post-translational regulation) [509 799–805] most often operate at the hub of adaptation to stress, hence mediating cytoprotective (rather than cytotoxic) effects [806–811].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [807]
In the citing paper
“CQ and its derivative hydroxychloroquine, a broadly used anti-malarial agent, are currently the only clinically available drugs to inhibit autophagy43.”
From AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields) (2018) · cites this paper as [43]
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Cites
1 retracted
RETRACTED: Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors
Tan, Q., Wang, M., Yu, M., Zhang, J., Bristow, R. G., Hill, R. P., & Tannock, I. F. (2016) · Neoplasia · doi:10.1016/j.neo.2016.04.003 · Cited by 102
RetractedGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
The role of autophagy during the early neonatal starvation period
Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
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The machinery of macroautophagy
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White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,758
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1 of the 141 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- The Nobel Assembly. The Nobel Assembly at Karolinska Institutet has today decided to award the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi https://www.nobelprize.org/nobel_prizes/medicine/laureates/2016/press.html (2016).
Cited by
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Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationBroadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 3,012
Targeting apoptosis in cancer therapy
Carneiro, B. A., & El‐Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,676
Autophagy and autophagy-related proteins in cancer
Li, X., He, S., & Ma, B. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1138-4 · Cited by 1,684
Lysosomes as dynamic regulators of cell and organismal homeostasis
Ballabio, A., & Bonifacino, J. S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0185-4 · Cited by 1,469
Metadata
- Authors
- Levy, J. M. M., Towers, C. G., & Thorburn, A.
- Affiliations
- Morgan Adams Foundation (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Thorburn, Andrew
- Venue
- Nature Reviews Cancer
- Published
- 2017-07-28
- Volume
- 17
- Issue
- 9
- Pages
- 528-542
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC5975367
- OpenAlex
- W2740618823
- Cited by
- 2,526
- References
- 141
- Citations by year
- 2026: 131 · 2025: 193 · 2024: 294 · 2023: 358 · 2022: 384 · 2021: 420 · 2020: 360 · 2019: 225 · 2018: 146 · 2017: 14
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA150925, K08CA193982, R01CA190170, R21CA197887, T32CA190216)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- autophagy, cancer therapy, autophagy inhibition, lysosomal degradation, clinical trial design
- MeSH terms
- Sequestosome-1 Protein, Animals, Antineoplastic Agents, Autophagy, Chloroquine, Clinical Trials as Topic, Humans, Hydroxychloroquine, Microtubule-Associated Proteins, Neoplasms, Biomarkers, Tumor, Tumor Escape
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