Cited by 2,526Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismUbiquitin and proteasome pathways

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Targeting autophagy in cancer

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Levy, Jean M. Mulcahy, Towers, Christina G., Thorburn, Andrew·2017·Nature Reviews Cancer

DOI 10.1038/nrc.2017.53PMC PMC5975367

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Abstract

Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.

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The Nobel Assembly. The Nobel Assembly at Karolinska Institutet has today decided to award the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi https://www.nobelprize.org/nobel_prizes/medicine/laureates/2016/press.html (2016).

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Authors: Levy, J. M. M., Towers, C. G., & Thorburn, A.
Affiliations: Morgan Adams Foundation (US)
University of Colorado Anschutz (US)
Corresponding author: Thorburn, Andrew
ORCID: Levy, Jean M. Mulcahy
Towers, Christina G.
Thorburn, Andrew
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2017-07-28
Volume: 17
Issue: 9
Pages: 528-542
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc.2017.53
PMC: PMC5975367
OpenAlex: W2740618823
Cited by: 2,526
References: 141
Citations by year: 2026: 131 · 2025: 193 · 2024: 294 · 2023: 358 · 2022: 384 · 2021: 420 · 2020: 360 · 2019: 225 · 2018: 146 · 2017: 14
FWCI: 27.26
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Helmholtz Centre for Ocean Research Kiel (GEOMAR) (acceptedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA150925, K08CA193982, R01CA190170, R21CA197887, T32CA190216)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagy, cancer therapy, autophagy inhibition, lysosomal degradation, clinical trial design
MeSH terms: Sequestosome-1 Protein, Animals, Antineoplastic Agents, Autophagy, Chloroquine, Clinical Trials as Topic, Humans, Hydroxychloroquine, Microtubule-Associated Proteins, Neoplasms, Biomarkers, Tumor, Tumor Escape

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