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Cited by 309

The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.

Gut microbiota injury in allogeneic haematopoietic stem cell transplantation

Open access
Shono, Yusuke, van den Brink, Marcel R. M.·2018·Nature Reviews Cancer

Abstract

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the strongest curative immunotherapy for various malignancies (primarily, but not limited to, haematologic malignancies). However, application of allo-HSCT is limited owing to its life-threatening major complications, such as graft-versus-host disease (GVHD), relapse and infections. Recent advances in large-scale DNA sequencing technology have facilitated rapid identification of the microorganisms that make up the microbiota and evaluation of their interactions with host immunity in various diseases, including cancer. This has resulted in renewed interest regarding the role of the intestinal flora in patients with haematopoietic malignancies who have received an allo-HSCT and in whether the microbiota affects clinical outcomes, including GVHD, relapse, infections and transplant-related mortality. In this Review, we discuss the potential role of intestinal microbiota in these major complications after allo-HSCT, summarize clinical trials evaluating the microbiota in patients who have received allo-HSCT and discuss how further studies of the microbiota could inform the development of strategies that improve outcomes of allo-HSCT.

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Metadata

Authors
Shono, Y., & van den Brink, M. R. M.
Venue
Nature Reviews Cancer
Published
2018-02-16
Volume
18
Issue
5
Pages
283-295
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2789147556
Cited by
309
References
153
FWCI
6.42
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. https://app.cochat.ai/papers/10.1038/nrc.2018.10
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Shono, Y., & van den Brink, M. R. M. (2018). Gut microbiota injury in allogeneic haematopoietic stem cell transplantation. Nature Reviews Cancer. https://doi.org/10.1038/nrc.2018.10

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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