The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy
Abstract
Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.
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“Necrotic tumor tissue does not present much harm to the host organism, but the hypoxic part of the tumor tissue and the hypoxic tumor cells are usually the major drivers of tumor progression [1–3].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [3]
In the citing paper
“Cancer hypoxia and the induced adaptation mechanisms are two of the major causes of therapy resistance.”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [3]
Citations
Cites
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Research works printed but not linked: 1
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Cited by
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Analysis of nanoparticle delivery to tumours
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The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
Metadata
- Authors
- Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A.
- Affiliations
- Ludwig Cancer Research (SE)
- Uppsala University (SE)
- University of California, San Francisco (US)
- Karolinska Institutet (SE)
- Corresponding author
- Heldin, Carl-Henrik
- Venue
- Nature reviews. Cancer
- Published
- 2004-10
- Volume
- 4
- Issue
- 10
- Pages
- 806-813
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2028156849
- Cited by
- 2,222
- References
- 78
- Citations by year
- 2026: 121 · 2025: 110 · 2024: 118 · 2023: 119 · 2022: 163 · 2021: 158 · 2020: 158 · 2019: 123 · 2018: 123 · 2017: 135 · 2016: 133 · 2015: 110 · 2014: 117 · 2013: 124 · 2012: 87
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- interstitial fluid pressure, solid tumors, tumor microenvironment, tumor fibrosis, anticancer drug delivery, tumor hypoxia
- MeSH terms
- Alprostadil, Animals, Antineoplastic Agents, Biological Transport, Bradykinin, Humans, Hyaluronoglucosaminidase, Hydrostatic Pressure, Neoplasms, Niacinamide, Platelet-Derived Growth Factor, Tumor Necrosis Factor-alpha, Signal Transduction, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Extracellular Fluid, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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