Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894 · see citing works

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works

Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1456 · Cited by 2,222 · see citing works

Pericytes are required for blood–brain barrier integrity during embryogenesis

Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128 · see citing works

A molecular atlas of cell types and zonation in the brain vasculature

Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature · doi:10.1038/nature25739 · Cited by 2,074 · see citing works

Endothelial/Pericyte Interactions

Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048 · see citing works

New tools for studying microglia in the mouse and human CNS

Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804 · see citing works

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Kadry, H., Noorani, B., & Cucullo, L. (2020) · Fluids and Barriers of the CNS · doi:10.1186/s12987-020-00230-3 · Cited by 1,853 · see citing works

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0297-y · Cited by 1,728 · see citing works

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670 · see citing works

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448 · see citing works

Pericytes of the neurovascular unit: key functions and signaling pathways

Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V. (2016) · Nature Neuroscience · doi:10.1038/nn.4288 · Cited by 1,125 · see citing works

Central nervous system pericytes in health and disease

Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962 · see citing works

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

Gaengel, K., Genové, G., Armulik, A., & Betsholtz, C. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.161521 · Cited by 933 · see citing works

Mechanisms of normal and tumor-derived angiogenesis

Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809 · see citing works

The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

Argaw, A. T., Gurfein, B. T., Zhang, Y., Zameer, A., & John, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808698106 · Cited by 666 · see citing works

The origin of fibroblasts and mechanism of cardiac fibrosis

Krenning, G., Zeisberg, E. M., & Kalluri, R. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22322 · Cited by 601 · see citing works

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

Daneman, R., Zhou, L., Agalliu, D., Cahoy, J. D., Kaushal, A., & Barres, B. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013741 · Cited by 577 · see citing works

The impact of microglial activation on blood-brain barrier in brain diseases

da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works

The meso-angioblast: A multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues

Minasi, M. G., Riminucci, M., De Angelis, L., Borello, U., Berarducci, B., Innocenzi, A., Caprioli, A., Sirabella, D., Baiocchi, M., De Maria, R., et al. (2002) · Development · doi:10.1242/dev.129.11.2773 · Cited by 514 · see citing works

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

Kisler, K., Nelson, A. R., Rege, S. V., Ramanathan, A., Wang, Y., Ahuja, A., Lazic, D., Tsai, P. S., Zhao, Z., Zhou, Y., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4489 · Cited by 497 · see citing works

No Identical “Mesenchymal Stem Cells” at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels

Sacchetti, B., Funari, A., Remoli, C., Giannicola, G., Kogler, G., Liedtke, S., Cossu, G., Serafini, M., Sampaolesi, M., Tagliafico, E., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.05.011 · Cited by 428 · see citing works

Brain endothelial cells and the glio-vascular complex

Wolburg, H., Noell, S., Mack, A., Wolburg-Buchholz, K., & Fallier-Becker, P. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0658-9 · Cited by 438 · see citing works

Insight into the physiological functions of PDGF through genetic studies in mice

Betsholtz, C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.005 · Cited by 437 · see citing works

Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review

Erdő, F., Denes, L., & de Lange, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16679420 · Cited by 426 · see citing works

Angiogenesis in the atherosclerotic plaque

Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401 · see citing works

Mechanisms of age‐related macular degeneration and therapeutic opportunities

van Lookeren Campagne, M., LeCouter, J., Yaspan, B. L., & Ye, W. (2014) · The Journal of Pathology · doi:10.1002/path.4266 · Cited by 382 · see citing works

Pericytes limit tumor cell metastasis

Xian, X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25705 · Cited by 345 · see citing works

The myofibroblast, a key cell in normal and pathological tissue repair

Darby, I. A., Zakuan, N., Billet, F., & Desmoulière, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2110-0 · Cited by 328 · see citing works

Novel insights into the development and maintenance of the blood-brain barrier

Engelhardt, B., & Liebner, S. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1811-2 · Cited by 313 · see citing works

Factors influencing the blood-brain barrier permeability

Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147937 · Cited by 291 · see citing works

Neuronal and vascular interactions

Andreone, B. J., Lacoste, B., & Gu, C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033835 · Cited by 256 · see citing works

Brain and Retinal Pericytes: Origin, Function and Role

Trost, A., Lange, S., Schroedl, F., Bruckner, D., Motloch, K. A., Bogner, B., Kaser-Eichberger, A., Strohmaier, C., Runge, C., Aigner, L., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00020 · Cited by 244 · see citing works

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

Berthiaume, A.-A., Grant, R. I., McDowell, K. P., Underly, R. G., Hartmann, D. A., Levy, M., Bhat, N. R., & Shih, A. Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.016 · Cited by 223 · see citing works

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226 · see citing works

A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation

Minutti, C. M., Modak, R. V., Macdonald, F., Li, F., Smyth, D. J., Dorward, D. A., Blair, N., Husovsky, C., Muir, A., Giampazolias, E., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.008 · Cited by 228 · see citing works

Neuroectodermal origin of brain pericytes and vascular smooth muscle cells

Korn, J., Christ, B., & Kurz, H. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.1423 · Cited by 208 · see citing works

Extracellular matrix scaffolding in angiogenesis and capillary homeostasis

Marchand, M., Monnot, C., Muller, L., & Germain, S. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2018.08.007 · Cited by 205 · see citing works

Endothelial-Specific Cre Mouse Models: Is Your Cre CREdibile?

Payne, S., De Val, S., & Neal, A. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.309669 · Cited by 196 · see citing works

Microarray analysis of blood microvessels from PDGF‐B and PDGF‐Rβ mutant mice identifies novel markers for brain pericytes

Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C., Bondjers, C., He, L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4944fje · Cited by 193 · see citing works

Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis

Cao, Y. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.002 · Cited by 190 · see citing works

Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development

Tallquist, M. D., French, W. J., & Soriano, P. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000052 · Cited by 192 · see citing works

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis

Heldin, C. ‐., Lennartsson, J., & Westermark, B. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12690 · Cited by 181 · see citing works

Gap Junction Communication Mediates Transforming Growth Factor-β Activation and Endothelial-Induced Mural Cell Differentiation

Hirschi, K. K., Burt, J. M., Hirschi, K. D., & Dai, C. (2003) · Circulation Research · doi:10.1161/01.res.0000091259.84556.d5 · Cited by 176 · see citing works

The Effects of Hemodynamic Force on Embryonic Development

CULVER, J. C., & DICKINSON, M. E. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00025.x · Cited by 173 · see citing works

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110961 · Cited by 167 · see citing works

Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis

Kreuger, J., & Phillipson, M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.2 · Cited by 160 · see citing works

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes

Sagare, A. P., Sweeney, M. D., Makshanoff, J., & Zlokovic, B. V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.025 · Cited by 142 · see citing works

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

Soto, I., Graham, L. C., Richter, H. J., Simeone, S. N., Radell, J. E., Grabowska, W., Funkhouser, W. K., Howell, M. C., & Howell, G. R. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002279 · Cited by 140 · see citing works

Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy

de Wilde, R. F., Edil, B. H., Hruban, R. H., & Maitra, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.9 · Cited by 122 · see citing works

Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance

Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127 · see citing works

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

He, L., Mäe, M. A., Muhl, L., Sun, Y., Pietilä, R., Nahar, K., Liébanas, E. V., Fagerlund, M. J., Oldner, A., Liu, J., et al. (2020) · doi:10.1101/2020.05.11.088500 · Cited by 116 · see citing works

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

Xue, Y., Cao, R., Nilsson, D., Chen, S., Westergren, R., Hedlund, E.-M., Martijn, C., Rondahl, L., Krauli, P., Walum, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802486105 · Cited by 112 · see citing works

Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile

Ganesan, P., Matsubara, K., Ohkubo, T., Tanaka, Y., Noda, K., Sugawara, T., & Hirata, T. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.05.005 · Cited by 112 · see citing works

Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia

Sheibani, N., Sorenson, C. M., Cornelius, L. A., & Frazier, W. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1903 · Cited by 109 · see citing works

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

Nikolakopoulou, A. M., Zhao, Z., Montagne, A., & Zlokovic, B. V. (2017) · PLOS ONE · doi:10.1371/journal.pone.0176225 · Cited by 109 · see citing works

Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs

Lu, H., Xu, X., Zhang, M., Cao, R., Bråkenhielm, E., Li, C., Lin, H., Yao, G., Sun, H., Qi, L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704966104 · Cited by 107 · see citing works

Interplay between Brain Pericytes and Endothelial Cells in Dementia

Procter, T. V., Williams, A., & Montagne, A. (2021) · The American Journal of Pathology · doi:10.1016/j.ajpath.2021.07.003 · Cited by 106 · see citing works

Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS

Buckner, C. M., Luers, A. J., Calderon, T. M., Eugenin, E. A., & Berman, J. W. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9017-3 · Cited by 88 · see citing works

Gamma interferon alters junctional integrity via rho kinase, resulting in blood-brain barrier leakage in experimental viral encephalitis.

Bonney, S., Seitz, S., Ryan, C. A., Jones, K. L., Clarke, P., Tyler, K. L., & Siegenthaler, J. A. (2019) · mBio · doi:10.1128/mbio.01675-19 · Cited by 79 · see citing works

Immunological defense of CNS barriers against infections

Ampie, L., & McGavern, D. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.012 · Cited by 63 · see citing works

Dasatinib

Lindauer, M., & Hochhaus, A. (2010) · Recent Results in Cancer Research · doi:10.1007/978-3-642-01222-8_7 · Cited by 57 · see citing works

Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer

Mezheyeuski, A., Lindh, M. B., Guren, T. K., Dragomir, A., Pfeiffer, P., Kure, E. H., Ikdahl, T., Skovlund, E., Corvigno, S., Strell, C., et al. (2106) · Oncotarget · doi:10.18632/oncotarget.9632 · Cited by 34 · see citing works

Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-β1

Schmid, S. A., Gaumann, A., Wondrak, M., Eckermann, C., Schulte, S., Mueller-Klieser, W., Wheatley, D. N., & Kunz-Schughart, L. A. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.016 · Cited by 26 · see citing works

Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS

Goncalves, A., & Antonetti, D. A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00386-0 · Cited by 22 · see citing works