Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Abstract
It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.
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Hbz plays an indispensable role in the maintenance of leukaemia and other HTLV-1-associated diseases.
“suggesting that it plays an indispensable role in the maintenance of leukaemia and other HTLV-1-associated diseases [87].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [87]
Many studies report an absence of tax expression in ATL cells.
“The traditional role assigned to Tax as a key player in leukaemia/lymphoma has also been challenged, as many studies report an absence of tax expression in ATL cells [87].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [87]
Cites
Taylor, G. P., Goon, P., Furukawa, Y., Green, H., Barfield, A., Mosley, A., Nose, H., Babiker, A., Rudge, P., Usuku, K., et al. (2006) · Retrovirology · doi:10.1186/1742-4690-3-63 · Cited by 117 · see citing works
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Redefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031 · see citing works
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001274 · Cited by 319 · see citing works
Self-citationMazurov, D., Ilinskaya, A., Heidecker, G., Lloyd, P., & Derse, D. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000788 · Cited by 217 · see citing works
Reducing the global burden of HTLV-1 infection: An agenda for research and action
Willems, L., Hasegawa, H., Accolla, R., Bangham, C., Bazarbachi, A., Bertazzoni, U., Carneiro-Proietti, A. B. D. F., Cheng, H., Chieco-Bianchi, L., Ciminale, V., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2016.10.015 · Cited by 140 · see citing works
Self-citationHuman T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis
Kannian, P., & Green, P. L. (2010) · Viruses · doi:10.3390/v2092037 · Cited by 139 · see citing works
Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
Enose-Akahata, Y., Vellucci, A., & Jacobson, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02563 · Cited by 88 · see citing works
The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells?
Ablain, J., Nasr, R., Bazarbachi, A., & de Thé, H. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0087 · Cited by 44 · see citing works
Current State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works
“Overexpression of Hbz was observed to prevent Tax-induced NF-κ B and PRC2 activation, shedding light on the co-modulatory interplay of Tax and Hbz [157].”
BackgroundOverexpression of caveolin-1 in adult T-cell leukemia
Sawada, S., Ishikawa, C., Tanji, H., Nakachi, S., Senba, M., Okudaira, T., Uchihara, J.-N., Taira, N., Ohshiro, K., Yamada, Y., et al. (2010) · Blood · doi:10.1182/blood-2009-08-240044 · Cited by 9 · see citing works
Retracted
- Authors
- Matsuoka, M., & Jeang, K.-T.
- Affiliations
- Kyoto University (JP)
- National Institutes of Health (US)
- Corresponding author
- Jeang, Kuan-Teh
- ORCID
- Matsuoka, Masao
- Venue
- Nature Reviews Cancer
- Published
- 2007-04
- Volume
- 7
- Issue
- 4
- Pages
- 270-280
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2094831592
- Cited by
- 829
- References
- 2
- Citations by year
- 2026: 21 · 2025: 33 · 2024: 21 · 2023: 21 · 2022: 46 · 2021: 41 · 2020: 41 · 2019: 26 · 2018: 32 · 2017: 45 · 2016: 38 · 2015: 52 · 2014: 52 · 2013: 54 · 2012: 49
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Keywords
- HTLV-1, adult T-cell leukemia/lymphoma, Tax oncoprotein, cell transformation, leukemogenesis, viral infectivity, aneuploidy, HBZ, minus-strand RNA, retroviral oncogenesis
- MeSH terms
- Aneuploidy, Cell Transformation, Neoplastic, Cell Transformation, Viral, DNA Damage, Humans, Mitosis, Models, Biological, Human T-lymphotropic virus 1, Leukemia-Lymphoma, Adult T-Cell, Gene Products, tax, Basic-Leucine Zipper Transcription Factors
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