HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
Open accessAbstract
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis, dermatitis, and inflammatory lung diseases. ATL cells, which constitutively express CD25, resemble CD25+CD4+ regulatory T cells (T(reg)). Approximately 60% of ATL cases indeed harbor leukemic cells that express FoxP3, a key transcription factor for T(reg) cells. HTLV-1 encodes an antisense transcript, HTLV-1 bZIP factor (HBZ), which is expressed in all ATL cases. In this study, we show that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals. In HBZ-transgenic mice, CD4+Foxp3+ T(reg) cells and effector/memory CD4+ T cells increased in vivo. As a mechanism of increased T(reg) cells, HBZ expression directly induced Foxp3 gene transcription in T cells. The increased CD4+Foxp3+ T(reg) cells in HBZ transgenic mice were functionally impaired while their proliferation was enhanced. HBZ could physically interact with Foxp3 and NFAT, thereby impairing the suppressive function of T(reg) cells. Thus, the expression of HBZ in CD4+ T cells is a key mechanism of HTLV-1-induced neoplastic and inflammatory diseases.
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Transgenic expression of HBZ in CD4+ T cells induced leukaemia and lymphoma following a long latent period.
“Transgenic expression of HBZ in CD4+ T cells induced leukaemia and lymphoma following a long latent period [145].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [145]
The Results section, “HBZ-Tg mice develop T-cell lymphoma after a long latent period” (page unavailable), reports that mice expressing HBZ in CD4+ T cells developed T-cell lymphoma after 16 months. It does not report that the mice developed leukaemia; it says their lymphomas phenotypically resembled human ATL. (LLM, conf=0.88)
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Self-citation
- Authors
- Satou, Y., Yasunaga, J.-I., Zhao, T., Yoshida, M., Miyazato, P., Takai, K., Shimizu, K., Ohshima, K., Green, P. L., Ohkura, N., Yamaguchi, T., Ono, M., Sakaguchi, S., & Matsuoka, M.
- Affiliations
- Kyoto University (JP)
- Kurume University (JP)
- The Ohio State University (US)
- Corresponding author
- Matsuoka, Masao
- ORCID
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-02-10
- Volume
- 7
- Issue
- 2
- Pages
- e1001274
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3037353
- OpenAlex
- W1966278500
- Cited by
- 319
- References
- 58
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 11 · 2023: 15 · 2022: 27 · 2021: 31 · 2020: 21 · 2019: 19 · 2018: 14 · 2017: 32 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 21 · 2012: 22
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
- Funders
- Naito Foundation
- Sumitomo Foundation
- Uehara Memorial Foundation
- National Institutes of Health
- Japan Society for the Promotion of Science (22390193)
- National Cancer Institute (CA077556, R01CA077556)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- HTLV-1, bZIP transcription factors, HBZ, adult T-cell leukemia/lymphoma, T-cell lymphoma, regulatory T cells, Foxp3, NFAT, systemic inflammation, CD4+ T cells, transgenic mice, HTLV-1-associated myelopathy/tropical spastic paraparesis, transcriptional regulation
- MeSH terms
- Adult, Animals, Cell Transformation, Viral, Cells, Cultured, Gene Expression Regulation, Humans, Inflammation, Mice, Inbred C57BL, Mice, Transgenic, Human T-lymphotropic virus 1, HTLV-I Infections, CD4-Positive T-Lymphocytes, Lymphoma, T-Cell, Basic-Leucine Zipper Transcription Factors, Mice
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