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DNA topoisomerase II and its growing repertoire of biological functions
Open accessAbstract
DNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA. Many of these can be solved by the generation of either single or double strand breaks. However, where there is a clear requirement to alter DNA topology by introducing transient double strand breaks, only DNA topoisomerase II (TOP2) can carry out this reaction. Extensive biochemical and structural studies have provided detailed models of how TOP2 alters DNA structure, and recent molecular studies have greatly expanded knowledge of the biological contexts in which TOP2 functions, such as DNA replication, transcription and chromosome segregation — processes that are essential for preventing tumorigenesis.
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Cited by
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Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
Thiazole-containing compounds as therapeutic targets for cancer therapy
Sharma, P. C., Bansal, K. K., Sharma, A., Sharma, D., & Deep, A. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.112016 · Cited by 382
New Mechanistic and Functional Insights into DNA Topoisomerases
Chen, S. H., Chan, N.-L., & Hsieh, T.-S. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061809-100002 · Cited by 369
Wiśniewski, J. R., Ostasiewicz, P., & Mann, M. (2011) · Journal of Proteome Research · doi:10.1021/pr200019m · Cited by 290
Irinotecan—Still an Important Player in Cancer Chemotherapy: A Comprehensive Overview
Kciuk, M., Marciniak, B., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144919 · Cited by 266
Metadata
- Authors
- Nitiss, J. L.
- Venue
- Nature Reviews Cancer
- Published
- 2009-04-20
- Volume
- 9
- Issue
- 5
- Pages
- 327-337
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2050788953
- Cited by
- 885
- References
- 0
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- green
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